6v48 - Revision history

OCA at 08:03, 11 October 2023

2023-10-11T08:03:31Z

←Older revision		Revision as of 08:03, 11 October 2023
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	==The crystal structure of hemagglutinin from A/mallard/Gurjev/263/1982 (H14N5)==		==The crystal structure of hemagglutinin from A/mallard/Gurjev/263/1982 (H14N5)==
-	<StructureSection load='6v48' size='340' side='right'caption='[[6v48]]' scene=''>	+	<StructureSection load='6v48' size='340' side='right'caption='[[6v48]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V48 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6V48 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6v48]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/mallard/Astrakhan/263/1982(H14N5)) Influenza A virus (A/mallard/Astrakhan/263/1982(H14N5))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V48 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6v48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v48 OCA], [~~http~~://pdbe.org/6v48 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6v48 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6v48 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6v48 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.004Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v48 OCA], [https://pdbe.org/6v48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v48 RCSB], [https://www.ebi.ac.uk/pdbsum/6v48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v48 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HEMA_I82A1 HEMA_I82A1] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072]
		+
		+	==See Also==
		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:13, 17 June 2020

2020-06-17T10:13:28Z

←Older revision		Revision as of 10:13, 17 June 2020
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-	'''Unreleased structure'''

-	~~The entry 6v48 is ON HOLD until Paper Publication~~	+	==The crystal structure of hemagglutinin from A/mallard/Gurjev/263/1982 (H14N5)==
-		+	<StructureSection load='6v48' size='340' side='right'caption='[[6v48]]' scene=''>
-	~~Authors: Yang, H., Stevens, J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V48 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V48 FirstGlance]. <br>
-	~~Description:~~ The crystal structure of hemagglutinin from A/mallard/Gurjev/263/1982 (H14N5)	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v48 OCA], [http://pdbe.org/6v48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v48 RCSB], [http://www.ebi.ac.uk/pdbsum/6v48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v48 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Yang~~, H]]	+	__TOC__
-	[[Category: Stevens, J]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Stevens J]]
		+	[[Category: Yang H]]

OCA at 06:11, 5 February 2020

2020-02-05T06:11:44Z

←Older revision		Revision as of 06:11, 5 February 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6v48 is ON HOLD	+	The entry 6v48 is ON HOLD until Paper Publication

	Authors: Yang, H., Stevens, J.		Authors: Yang, H., Stevens, J.

OCA: Protected "6v48" [edit=sysop:move=sysop]

2019-12-04T06:42:04Z

Protected "6v48" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:42, 4 December 2019

OCA: New page: '''Unreleased structure''' The entry 6v48 is ON HOLD Authors: Yang, H., Stevens, J. Description: The crystal structure of hemagglutinin from A/mallard/Gurjev/263/1982 (H14N5) [[Categor...

2019-12-04T06:42:02Z

New page: '''Unreleased structure''' The entry 6v48 is ON HOLD Authors: Yang, H., Stevens, J. Description: The crystal structure of hemagglutinin from A/mallard/Gurjev/263/1982 (H14N5) [[Categor...

New page

'''Unreleased structure'''

The entry 6v48 is ON HOLD

Authors: Yang, H., Stevens, J.

Description: The crystal structure of hemagglutinin from A/mallard/Gurjev/263/1982 (H14N5)
[[Category: Unreleased Structures]]
[[Category: Yang, H]]
[[Category: Stevens, J]]