OCA at 17:00, 22 January 2020

2020-01-22T17:00:40Z

←Older revision		Revision as of 17:00, 22 January 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6v55 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Full extracellular region of zebrafish Gpr126/Adgrg6==
		+	<StructureSection load='6v55' size='340' side='right'caption='[[6v55]], [[Resolution\|resolution]] 2.38Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6v55]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6V55 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">adgrg6, gpr126 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6v55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v55 OCA], [http://pdbe.org/6v55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v55 RCSB], [http://www.ebi.ac.uk/pdbsum/6v55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v55 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AGRG6_DANRE AGRG6_DANRE]] G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins (PubMed:25118328). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:19745155). Plays also a role in inner ear development (PubMed:24067352).[UniProtKB:Q86SQ4]<ref>PMID:19745155</ref> <ref>PMID:24067352</ref> <ref>PMID:25118328</ref> Plays an important role in heart development (PubMed:24082093). Necessary and sufficient for axon sorting by Schwann cells independently of the ADGRG6-CTF (PubMed:25695270).<ref>PMID:24082093</ref> <ref>PMID:25695270</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many drugs target the extracellular regions (ECRs) of cell-surface receptors. The large and alternatively-spliced ECRs of adhesion G protein-coupled receptors (aGPCRs) have key functions in diverse biological processes including neurodevelopment, embryogenesis, and tumorigenesis. However, their structures and mechanisms of action remain unclear, hampering drug development. The aGPCR Gpr126/Adgrg6 regulates Schwann cell myelination, ear canal formation, and heart development; and GPR126 mutations cause myelination defects in human. Here, we determine the structure of the complete zebrafish Gpr126 ECR and reveal five domains including a previously unknown domain. Strikingly, the Gpr126 ECR adopts a closed conformation that is stabilized by an alternatively spliced linker and a conserved calcium-binding site. Alternative splicing regulates ECR conformation and receptor signaling, while mutagenesis of the calcium-binding site abolishes Gpr126 function in vivo. These results demonstrate that Gpr126 ECR utilizes a multi-faceted dynamic approach to regulate receptor function and provide relevant insights for ECR-targeted drug design.

-	~~Authors~~:	+	Structural basis for adhesion G protein-coupled receptor Gpr126 function.,Leon K, Cunningham RL, Riback JA, Feldman E, Li J, Sosnick TR, Zhao M, Monk KR, Arac D Nat Commun. 2020 Jan 10;11(1):194. doi: 10.1038/s41467-019-14040-1. PMID:31924782<ref>PMID:31924782</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6v55" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brachidanio rerio]]
		+	[[Category: Large Structures]]
		+	[[Category: Arac, D]]
		+	[[Category: Leon, K]]
		+	[[Category: Adhesion g-protein coupled receptor]]
		+	[[Category: Calcium-binding]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Myelination]]

OCA at 07:29, 25 December 2019

2019-12-25T07:29:41Z

←Older revision		Revision as of 07:29, 25 December 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6v55 is ON HOLD	+	The entry 6v55 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6v55" [edit=sysop:move=sysop]

2019-12-11T13:45:36Z

Protected "6v55" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:45, 11 December 2019

OCA: New page: '''Unreleased structure''' The entry 6v55 is ON HOLD Authors: Description: Category: Unreleased Structures

2019-12-11T13:45:35Z

New page: '''Unreleased structure''' The entry 6v55 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6v55 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6v55 - Revision history

OCA at 17:00, 22 January 2020

OCA at 07:29, 25 December 2019

OCA: Protected "6v55" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6v55 is ON HOLD Authors: Description: Category: Unreleased Structures