6ve7 - Revision history

OCA at 07:08, 11 April 2020

2020-04-11T07:08:18Z

←Older revision		Revision as of 07:08, 11 April 2020
Line 3:		Line 3:
	<SX load='6ve7' size='340' side='right' viewer='molstar' caption='[[6ve7]], [[Resolution\|resolution]] 3.60Å' scene=''>		<SX load='6ve7' size='340' side='right' viewer='molstar' caption='[[6ve7]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ve7]] is a 62 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VE7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6VE7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ve7]] is a 62 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VE7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VE7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ve7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ve7 OCA], [http://pdbe.org/6ve7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ve7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ve7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ve7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ve7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ve7 OCA], [http://pdbe.org/6ve7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ve7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ve7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ve7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 01:25, 7 March 2020

2020-03-07T01:25:27Z

←Older revision		Revision as of 01:25, 7 March 2020
Line 1:		Line 1:

	==The inner junction complex of Chlamydomonas reinhardtii doublet microtubule==		==The inner junction complex of Chlamydomonas reinhardtii doublet microtubule==
-	<~~StructureSection~~ load='6ve7' size='340' side='right'caption='[[6ve7]], [[Resolution\|resolution]] 3.60Å' scene=''>	+	<SX load='6ve7' size='340' side='right' viewer='molstar' caption='[[6ve7]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6ve7]] is a 62 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VE7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6ve7]] is a 62 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VE7 FirstGlance]. <br>
Line 21:		Line 21:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Chlamydomonas reinhardtii]]		[[Category: Chlamydomonas reinhardtii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 08:18, 5 February 2020

2020-02-05T08:18:46Z

←Older revision		Revision as of 08:18, 5 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 6ve7 is ~~ON HOLD~~	+	==The inner junction complex of Chlamydomonas reinhardtii doublet microtubule==
		+	<StructureSection load='6ve7' size='340' side='right'caption='[[6ve7]], [[Resolution\|resolution]] 3.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ve7]] is a 62 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VE7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ve7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ve7 OCA], [http://pdbe.org/6ve7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ve7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ve7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ve7 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TBA1_CHLRE TBA1_CHLRE]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/CFA20_CHLRE CFA20_CHLRE]] Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (PubMed:24259666, PubMed:24574454). Involved in the control of flagellar beating in an asymmetric and planar waveform (PubMed:24259666, PubMed:24574454). Stabilizes outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1, 5 and 6 (PubMed:24259666, PubMed:24574454). Not essential for flagellar assembly (PubMed:24574454).<ref>PMID:24259666</ref> <ref>PMID:24574454</ref> [[http://www.uniprot.org/uniprot/FLTOP_CHLRE FLTOP_CHLRE]] May act as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells.[UniProtKB:Q6P8X9] [[http://www.uniprot.org/uniprot/TBB_CHLRE TBB_CHLRE]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Microtubules are cytoskeletal structures involved in stability, transport and organization in the cell. The building blocks, the alpha- and beta-tubulin heterodimers, form protofilaments that associate laterally into the hollow microtubule. Microtubule also exists as highly stable doublet microtubules in the cilia where stability is needed for ciliary beating and function. The doublet microtubule maintains its stability through interactions at its inner and outer junctions where its A- and B-tubules meet. Here, using cryo-electron microscopy, bioinformatics and mass spectrometry of the doublets of Chlamydomonas reinhardtii and Tetrahymena thermophila, we identified two new inner junction proteins, FAP276 and FAP106, and an inner junction-associated protein, FAP126, thus presenting the complete answer to the inner junction identity and localization. Our structural study of the doublets shows that the inner junction serves as an interaction hub that involves tubulin post-translational modifications. These interactions contribute to the stability of the doublet and hence, normal ciliary motility.

-	~~Authors~~:	+	The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications.,Khalifa AAZ, Ichikawa M, Dai D, Kubo S, Black CS, Peri K, McAlear TS, Veyron S, Yang SK, Vargas J, Bechstedt S, Trempe JF, Bui KH Elife. 2020 Jan 17;9. pii: 52760. doi: 10.7554/eLife.52760. PMID:31951202<ref>PMID:31951202</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6ve7" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chlamydomonas reinhardtii]]
		+	[[Category: Large Structures]]
		+	[[Category: Bui, K H]]
		+	[[Category: Ichikawa, M]]
		+	[[Category: Khalifa, A A.Z]]
		+	[[Category: Axoneme]]
		+	[[Category: Cilia]]
		+	[[Category: Doublet]]
		+	[[Category: Microtubule inner protein]]
		+	[[Category: Structural protein]]

OCA: Protected "6ve7" [edit=sysop:move=sysop]

2020-01-08T06:13:13Z

Protected "6ve7" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:13, 8 January 2020

OCA: New page: '''Unreleased structure''' The entry 6ve7 is ON HOLD Authors: Description: Category: Unreleased Structures

2020-01-08T06:13:11Z

New page: '''Unreleased structure''' The entry 6ve7 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ve7 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]