6vea - Revision history

OCA at 08:10, 11 October 2023

2023-10-11T08:10:12Z

←Older revision		Revision as of 08:10, 11 October 2023
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	<StructureSection load='6vea' size='340' side='right'caption='[[6vea]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='6vea' size='340' side='right'caption='[[6vea]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6vea]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VEA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6VEA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vea]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VEA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.58Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLR3.2, GLUR2, At4g35290, F23E12.150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6vea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vea OCA], [~~http~~://pdbe.org/6vea PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6vea RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6vea PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6vea ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vea OCA], [https://pdbe.org/6vea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vea RCSB], [https://www.ebi.ac.uk/pdbsum/6vea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vea ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GLR32_ARATH GLR32_ARATH]] Glutamate-gated receptor that probably acts as non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells. Could play a role in calcium unloading from xylem.	+	[https://www.uniprot.org/uniprot/GLR32_ARATH GLR32_ARATH] Glutamate-gated receptor that probably acts as non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells. Could play a role in calcium unloading from xylem.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gangwar~~, S P~~]]	+	[[Category: Gangwar SP]]
-	[[Category: Green~~, M N~~]]	+	[[Category: Green MN]]
-	[[Category: Sobolevsky~~, A I~~]]	+	[[Category: Sobolevsky AI]]
-	[[Category: Yoder~~, J B]]~~	+	[[Category: Yoder JB]]
-	~~[[Category: Arabidopsis]]~~	+
-	~~[[Category: Glutamate like receptor]]~~	+
-	~~[[Category: Ion channel]]~~	+
-	~~[[Category: Ligand-binding domain]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 09:52, 18 November 2020

2020-11-18T09:52:31Z

←Older revision		Revision as of 09:52, 18 November 2020
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	==Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain in complex with Glycine==		==Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain in complex with Glycine==
-	<StructureSection load='6vea' size='340' side='right'caption='[[6vea]]' scene=''>	+	<StructureSection load='6vea' size='340' side='right'caption='[[6vea]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VEA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VEA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vea]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VEA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VEA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vea OCA], [http://pdbe.org/6vea PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vea RCSB], [http://www.ebi.ac.uk/pdbsum/6vea PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vea ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLR3.2, GLUR2, At4g35290, F23E12.150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vea OCA], [http://pdbe.org/6vea PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vea RCSB], [http://www.ebi.ac.uk/pdbsum/6vea PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vea ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GLR32_ARATH GLR32_ARATH]] Glutamate-gated receptor that probably acts as non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells. Could play a role in calcium unloading from xylem.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glutamate receptor-like channels (GLRs) play important roles in numerous plant physiological processes. GLRs are homologous to ionotropic glutamate receptors (iGluRs) that mediate neurotransmission in vertebrates. Here we determine crystal structures of Arabidopsis thaliana GLR3.2 ligand-binding domain (LBD) in complex with glycine and methionine to 1.58- and 1.75-A resolution, respectively. Our structures show a fold similar to that of iGluRs, but with several secondary structure elements either missing or different. The closed clamshell conformation of GLR3.2 LBD suggests that both glycine and methionine act as agonists. The mutation R133A strongly increases the constitutive activity of the channel, suggesting that the LBD mutated at the residue critical for agonist binding produces a more stable closed clamshell conformation. Furthermore, our structures explain the promiscuity of GLR activation by different amino acids, confirm evolutionary conservation of structure between GLRs and iGluRs, and predict common molecular principles of their gating mechanisms driven by bilobed clamshell-like LBDs.
		+
		+	Structure of the Arabidopsis Glutamate Receptor-like Channel GLR3.2 Ligand-Binding Domain.,Gangwar SP, Green MN, Michard E, Simon AA, Feijo JA, Sobolevsky AI Structure. 2020 Sep 28. pii: S0969-2126(20)30331-2. doi:, 10.1016/j.str.2020.09.006. PMID:33027636<ref>PMID:33027636</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6vea" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gangwar SP]]	+	[[Category: Gangwar, S P]]
-	[[Category: Green MN]]	+	[[Category: Green, M N]]
-	[[Category: Sobolevsky AI]]	+	[[Category: Sobolevsky, A I]]
-	[[Category: Yoder JB]]	+	[[Category: Yoder, J B]]
		+	[[Category: Arabidopsis]]
		+	[[Category: Glutamate like receptor]]
		+	[[Category: Ion channel]]
		+	[[Category: Ligand-binding domain]]
		+	[[Category: Membrane protein]]

OCA at 11:11, 23 September 2020

2020-09-23T11:11:11Z

←Older revision		Revision as of 11:11, 23 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6vea ~~is ON HOLD~~	+	==Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain in complex with Glycine==
-		+	<StructureSection load='6vea' size='340' side='right'caption='[[6vea]]' scene=''>
-	~~Authors~~: ~~Gangwar, S~~.P., ~~Green, M~~.N., ~~Yoder~~, J.B., ~~Sobolevsky, A~~.I.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VEA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VEA FirstGlance]. <br>
-	~~Description~~: ~~Structure of the Glutamate-Like Receptor GLR3~~.~~2 ligand~~-~~binding domain in complex with Glycine~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vea OCA], [http://pdbe.org/6vea PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vea RCSB], [http://www.ebi.ac.uk/pdbsum/6vea PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vea ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Green, M.N~~]]	+	__TOC__
-	[[Category: ~~Sobolevsky, A.I~~]]	+	</StructureSection>
-	[[Category: ~~Gangwar, S.P~~]]	+	[[Category: Large Structures]]
-	[[Category: Yoder~~, J.B~~]]	+	[[Category: Gangwar SP]]
		+	[[Category: Green MN]]
		+	[[Category: Sobolevsky AI]]
		+	[[Category: Yoder JB]]

OCA at 04:29, 19 August 2020

2020-08-19T04:29:12Z

←Older revision		Revision as of 04:29, 19 August 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6vea is ON HOLD ~~until Paper Publication~~	+	The entry 6vea is ON HOLD

	Authors: Gangwar, S.P., Green, M.N., Yoder, J.B., Sobolevsky, A.I.		Authors: Gangwar, S.P., Green, M.N., Yoder, J.B., Sobolevsky, A.I.
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	Description: Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain in complex with Glycine		Description: Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain in complex with Glycine
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Gangwar, S.P]]
	[[Category: Green, M.N]]		[[Category: Green, M.N]]
	[[Category: Sobolevsky, A.I]]		[[Category: Sobolevsky, A.I]]
		+	[[Category: Gangwar, S.P]]
	[[Category: Yoder, J.B]]		[[Category: Yoder, J.B]]

OCA at 03:50, 13 May 2020

2020-05-13T03:50:28Z

←Older revision		Revision as of 03:50, 13 May 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6vea is ON HOLD	+	The entry 6vea is ON HOLD until Paper Publication

	Authors: Gangwar, S.P., Green, M.N., Yoder, J.B., Sobolevsky, A.I.		Authors: Gangwar, S.P., Green, M.N., Yoder, J.B., Sobolevsky, A.I.
Line 7:		Line 7:
	Description: Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain in complex with Glycine		Description: Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain in complex with Glycine
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Sobolevsky, A.I]]
-	[[Category: Yoder, J.B]]
	[[Category: Gangwar, S.P]]		[[Category: Gangwar, S.P]]
	[[Category: Green, M.N]]		[[Category: Green, M.N]]
		+	[[Category: Sobolevsky, A.I]]
		+	[[Category: Yoder, J.B]]

OCA: Protected "6vea" [edit=sysop:move=sysop]

2020-01-08T06:13:45Z

Protected "6vea" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:13, 8 January 2020

OCA: New page: '''Unreleased structure''' The entry 6vea is ON HOLD Authors: Gangwar, S.P., Green, M.N., Yoder, J.B., Sobolevsky, A.I. Description: Structure of the Glutamate-Like Receptor GLR3.2 lig...

2020-01-08T06:13:43Z

New page: '''Unreleased structure''' The entry 6vea is ON HOLD Authors: Gangwar, S.P., Green, M.N., Yoder, J.B., Sobolevsky, A.I. Description: Structure of the Glutamate-Like Receptor GLR3.2 lig...

New page

'''Unreleased structure'''

The entry 6vea is ON HOLD

Authors: Gangwar, S.P., Green, M.N., Yoder, J.B., Sobolevsky, A.I.

Description: Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain in complex with Glycine
[[Category: Unreleased Structures]]
[[Category: Sobolevsky, A.I]]
[[Category: Yoder, J.B]]
[[Category: Gangwar, S.P]]
[[Category: Green, M.N]]