6vft - Revision history

OCA at 08:11, 11 October 2023

2023-10-11T08:11:12Z

←Older revision		Revision as of 08:11, 11 October 2023
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	<StructureSection load='6vft' size='340' side='right'caption='[[6vft]], [[Resolution\|resolution]] 3.71Å' scene=''>		<StructureSection load='6vft' size='340' side='right'caption='[[6vft]], [[Resolution\|resolution]] 3.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6vft]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VFT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6VFT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vft]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VFT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.71Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca.weizmann~~.~~ac.il/oca-docs~~/fgij/fg.htm?mol=6vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vft OCA], [~~http~~://pdbe.org/6vft PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6vft RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6vft PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6vft ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vft OCA], [https://pdbe.org/6vft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vft RCSB], [https://www.ebi.ac.uk/pdbsum/6vft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vft ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PCD17_HUMAN PCD17_HUMAN]] Potential calcium-dependent cell-adhesion protein.	+	[https://www.uniprot.org/uniprot/PCD17_HUMAN PCD17_HUMAN] Potential calcium-dependent cell-adhesion protein.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6vft" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6vft" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cadherin 3D structures\|Cadherin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brasch, J]]	+	[[Category: Brasch J]]
-	[[Category: Harrison~~, O J~~]]	+	[[Category: Harrison OJ]]
-	[[Category: Shapiro, L]]	+	[[Category: Shapiro L]]
-	~~[[Category: Adhesion molecule]]~~	+
-	~~[[Category: Cadherin extracellular region]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Non-clustered delta2 family]]~~	+
-	~~[[Category: Protocadherin homophilic adhesion/recognition calcium-dependent~~]]	+

OCA at 07:31, 11 March 2020

2020-03-11T07:31:22Z

←Older revision		Revision as of 07:31, 11 March 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6vft is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of human delta protocadherin 17 EC1-EC4==
		+	<StructureSection load='6vft' size='340' side='right'caption='[[6vft]], [[Resolution\|resolution]] 3.71Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6vft]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VFT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vft OCA], [http://pdbe.org/6vft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vft RCSB], [http://www.ebi.ac.uk/pdbsum/6vft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vft ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PCD17_HUMAN PCD17_HUMAN]] Potential calcium-dependent cell-adhesion protein.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Non-clustered delta1- and delta2-protocadherins, close relatives of clustered protocadherins, function in cell adhesion and motility and play essential roles in neural patterning. To understand the molecular interactions underlying these functions, we used solution biophysics to characterize binding of delta1- and delta2-protocadherins, determined crystal structures of ectodomain complexes from each family, and assessed ectodomain assembly in reconstituted intermembrane junctions by cryoelectron tomography (cryo-ET). Homophilic trans (cell-cell) interactions were preferred for all delta-protocadherins, with additional weaker heterophilic interactions observed exclusively within each subfamily. As expected, delta1- and delta2-protocadherin trans dimers formed through antiparallel EC1-EC4 interfaces, like clustered protocadherins. However, no ectodomain-mediated cis (same-cell) interactions were detectable in solution; consistent with this, cryo-ET of reconstituted junctions revealed dense assemblies lacking the characteristic order observed for clustered protocadherins. Our results define non-clustered protocadherin binding properties and their structural basis, providing a foundation for interpreting their functional roles in neural patterning.

-	~~Authors~~:	+	Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered delta-Protocadherins.,Harrison OJ, Brasch J, Katsamba PS, Ahlsen G, Noble AJ, Dan H, Sampogna RV, Potter CS, Carragher B, Honig B, Shapiro L Cell Rep. 2020 Feb 25;30(8):2655-2671.e7. doi: 10.1016/j.celrep.2020.02.003. PMID:32101743<ref>PMID:32101743</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6vft" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Brasch, J]]
		+	[[Category: Harrison, O J]]
		+	[[Category: Shapiro, L]]
		+	[[Category: Adhesion molecule]]
		+	[[Category: Cadherin extracellular region]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Non-clustered delta2 family]]
		+	[[Category: Protocadherin homophilic adhesion/recognition calcium-dependent]]

OCA at 06:13, 5 February 2020

2020-02-05T06:13:37Z

←Older revision		Revision as of 06:13, 5 February 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6vft is ON HOLD	+	The entry 6vft is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6vft" [edit=sysop:move=sysop]

2020-01-22T14:23:12Z

Protected "6vft" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:23, 22 January 2020

OCA: New page: '''Unreleased structure''' The entry 6vft is ON HOLD Authors: Description: Category: Unreleased Structures

2020-01-22T14:23:11Z

New page: '''Unreleased structure''' The entry 6vft is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6vft is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]