6vj1 - Revision history

OCA: Redirecting to 7uj7

2022-05-04T12:45:30Z

Redirecting to 7uj7

←Older revision		Revision as of 12:45, 4 May 2022
Line 1:		Line 1:
-		+	#REDIRECT [[7uj7]] This PDB entry is obsolete and replaced by 7uj7
-	~~==Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with RU39411==~~	+
-	~~<StructureSection load='6vj1' size='340' side='right'caption='~~[[~~6vj1]], [[Resolution\|resolution]] 1.68Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[6vj1~~]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VJ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VJ1 FirstGlance]. <br>	+
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QYM:(9beta,11beta,17beta)-11-{4-[2-(dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol'>QYM</scene></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vj1 OCA], [http://pdbe.org/6vj1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vj1 RCSB], [http://www.ebi.ac.uk/pdbsum/6vj1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vj1 ProSAT]</span></td></tr>	+
-	~~</table>~~	+
-	~~== Function ==~~	+
-	~~[[http://www.uniprot.org/uniprot/ESR1_HUMAN ESR1_HUMAN]] Nuclear hormone receptor. The steroid hormones~~ and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Isoform 3 can bind to ERE and inhibit isoform 1.<ref>PMID:7651415</ref> <ref>PMID:10970861</ref> <ref>PMID:9328340</ref> <ref>PMID:10681512</ref> <ref>PMID:10816575</ref> <ref>PMID:11477071</ref> <ref>PMID:11682626</ref> <ref>PMID:15078875</ref> <ref>PMID:16043358</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref> <ref>PMID:18247370</ref> <ref>PMID:17932106</ref> <ref>PMID:19350539</ref> <ref>PMID:20705611</ref> <ref>PMID:21937726</ref> <ref>PMID:21330404</ref> <ref>PMID:22083956</ref>	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Large Structures]]~~	+
-	~~[[Category: Fanning, S W]]~~	+
-	~~[[Category: Greene, G L]]~~	+
-	~~[[Category: Activating mutation]]~~	+
-	~~[[Category: Estrogen receptor]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Ru39411]]~~	+
-	~~[[Category: Serm]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Y537]]~~	+

OCA at 09:28, 26 February 2020

2020-02-26T09:28:08Z

←Older revision		Revision as of 09:28, 26 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6vj1 is ~~ON HOLD~~	+	==Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with RU39411==
-		+	<StructureSection load='6vj1' size='340' side='right'caption='[[6vj1]], [[Resolution\|resolution]] 1.68Å' scene=''>
-	~~Authors~~: ~~Fanning~~, S.W., ~~Greene~~, G.L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6vj1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VJ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VJ1 FirstGlance]. <br>
-	~~Description~~: ~~Estrogen Receptor Alpha~~ Ligand ~~Binding Domain Y537S Mutant~~ in ~~Complex~~ with ~~RU39411~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QYM:(9beta,11beta,17beta)-11-{4-[2-(dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol'>QYM</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vj1 OCA], [http://pdbe.org/6vj1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vj1 RCSB], [http://www.ebi.ac.uk/pdbsum/6vj1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vj1 ProSAT]</span></td></tr>
-	[[Category: Greene, G.L]]	+	</table>
-	[[Category: ~~Fanning, S.W~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ESR1_HUMAN ESR1_HUMAN]] Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Isoform 3 can bind to ERE and inhibit isoform 1.<ref>PMID:7651415</ref> <ref>PMID:10970861</ref> <ref>PMID:9328340</ref> <ref>PMID:10681512</ref> <ref>PMID:10816575</ref> <ref>PMID:11477071</ref> <ref>PMID:11682626</ref> <ref>PMID:15078875</ref> <ref>PMID:16043358</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref> <ref>PMID:18247370</ref> <ref>PMID:17932106</ref> <ref>PMID:19350539</ref> <ref>PMID:20705611</ref> <ref>PMID:21937726</ref> <ref>PMID:21330404</ref> <ref>PMID:22083956</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Fanning, S W]]
		+	[[Category: Greene, G L]]
		+	[[Category: Activating mutation]]
		+	[[Category: Estrogen receptor]]
		+	[[Category: Hormone]]
		+	[[Category: Ru39411]]
		+	[[Category: Serm]]
		+	[[Category: Transcription]]
		+	[[Category: Y537]]

OCA: Protected "6vj1" [edit=sysop:move=sysop]

2020-01-22T14:33:55Z

Protected "6vj1" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:33, 22 January 2020

OCA: New page: '''Unreleased structure''' The entry 6vj1 is ON HOLD Authors: Fanning, S.W., Greene, G.L. Description: Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with RU3941...

2020-01-22T14:33:53Z

New page: '''Unreleased structure''' The entry 6vj1 is ON HOLD Authors: Fanning, S.W., Greene, G.L. Description: Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with RU3941...

New page

'''Unreleased structure'''

The entry 6vj1 is ON HOLD

Authors: Fanning, S.W., Greene, G.L.

Description: Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with RU39411
[[Category: Unreleased Structures]]
[[Category: Greene, G.L]]
[[Category: Fanning, S.W]]