6vji - Revision history

OCA at 09:54, 9 September 2020

2020-09-09T09:54:28Z

←Older revision		Revision as of 09:54, 9 September 2020
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	==Structure of mammalian NEIL2 from Monodelphis domestica==		==Structure of mammalian NEIL2 from Monodelphis domestica==
-	<StructureSection load='6vji' size='340' side='right'caption='[[6vji]]' scene=''>	+	<StructureSection load='6vji' size='340' side='right'caption='[[6vji]], [[Resolution\|resolution]] 2.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VJI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VJI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vji]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gray_short-tailed_opossum Gray short-tailed opossum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VJI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VJI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vji OCA], [http://pdbe.org/6vji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vji RCSB], [http://www.ebi.ac.uk/pdbsum/6vji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vji ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NEIL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=13616 Gray short-tailed opossum])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vji OCA], [http://pdbe.org/6vji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vji RCSB], [http://www.ebi.ac.uk/pdbsum/6vji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vji ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Oxidative damage on DNA arising from both endogenous and exogenous sources can result in base modifications that promote errors in replication as well as generating sites of base loss (abasic sites) that present unique challenges to maintaining genomic integrity. These lesions are excised by DNA glycosylases in the first step of the base excision repair pathway. Here we present the first crystal structure of a NEIL2 glycosylase, an enzyme active on cytosine oxidation products and abasic sites. The structure reveals an unusual "open" conformation not seen in NEIL1 or NEIL3 orthologs. NEIL2 is predicted to adopt a "closed" conformation when bound to its substrate. Combined crystallographic and solution-scattering studies show the enzyme to be conformationally dynamic in a manner distinct among the NEIL glycosylases and provide insight into the unique substrate preference of this enzyme. In addition, we characterized three cancer variants of human NEIL2, namely S140N, G230W, and G303R.
		+
		+	Unique Structural Features of Mammalian NEIL2 DNA Glycosylase Prime Its Activity for Diverse DNA Substrates and Environments.,Eckenroth BE, Cao VB, Averill AM, Dragon JA, Doublie S Structure. 2020 Aug 15. pii: S0969-2126(20)30283-5. doi:, 10.1016/j.str.2020.08.001. PMID:32846144<ref>PMID:32846144</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6vji" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Gray short-tailed opossum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Doublie S]]	+	[[Category: Doublie, S]]
-	[[Category: Eckenroth BE]]	+	[[Category: Eckenroth, B E]]
		+	[[Category: Base excision repair]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Neil2]]

OCA at 09:47, 12 August 2020

2020-08-12T09:47:38Z

←Older revision		Revision as of 09:47, 12 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6vji ~~is ON HOLD until Paper Publication~~	+	==Structure of mammalian NEIL2 from Monodelphis domestica==
-		+	<StructureSection load='6vji' size='340' side='right'caption='[[6vji]]' scene=''>
-	~~Authors~~: ~~Eckenroth~~, B.E., ~~Doublie~~, S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VJI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VJI FirstGlance]. <br>
-	~~Description: Structure of mammalian NEIL2 from Monodelphis domestica~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vji OCA], [http://pdbe.org/6vji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vji RCSB], [http://www.ebi.ac.uk/pdbsum/6vji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vji ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Eckenroth, B.E~~]]	+	__TOC__
-	[[Category: ~~Doublie, S~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Doublie S]]
		+	[[Category: Eckenroth BE]]

OCA at 03:51, 13 May 2020

2020-05-13T03:51:30Z

←Older revision		Revision as of 03:51, 13 May 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6vji is ON HOLD	+	The entry 6vji is ON HOLD until Paper Publication

	Authors: Eckenroth, B.E., Doublie, S.		Authors: Eckenroth, B.E., Doublie, S.

OCA: Protected "6vji" [edit=sysop:move=sysop]

2020-01-22T14:35:39Z

Protected "6vji" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:35, 22 January 2020

OCA: New page: '''Unreleased structure''' The entry 6vji is ON HOLD Authors: Eckenroth, B.E., Doublie, S. Description: Structure of mammalian NEIL2 from Monodelphis domestica [[Category: Unreleased S...

2020-01-22T14:35:37Z

New page: '''Unreleased structure''' The entry 6vji is ON HOLD Authors: Eckenroth, B.E., Doublie, S. Description: Structure of mammalian NEIL2 from Monodelphis domestica [[Category: Unreleased S...

New page

'''Unreleased structure'''

The entry 6vji is ON HOLD

Authors: Eckenroth, B.E., Doublie, S.

Description: Structure of mammalian NEIL2 from Monodelphis domestica
[[Category: Unreleased Structures]]
[[Category: Eckenroth, B.E]]
[[Category: Doublie, S]]