6vpn - Revision history

OCA at 11:06, 14 June 2023

2023-06-14T11:06:03Z

←Older revision		Revision as of 11:06, 14 June 2023
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	==Solution structure of antifungal plant defensin PvD1==		==Solution structure of antifungal plant defensin PvD1==
-	<StructureSection load='6vpn' size='340' side='right'caption='[[6vpn~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6vpn' size='340' side='right'caption='[[6vpn]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6vpn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Phaseolus_vulgaris Phaseolus vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VPN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6VPN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phaseolus_vulgaris Phaseolus vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VPN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6vpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vpn OCA], [~~http~~://pdbe.org/6vpn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6vpn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6vpn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6vpn ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vpn OCA], [https://pdbe.org/6vpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vpn RCSB], [https://www.ebi.ac.uk/pdbsum/6vpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vpn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/V7BTW4_PHAVU V7BTW4_PHAVU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Phaseolus vulgaris]]		[[Category: Phaseolus vulgaris]]
-	[[Category: Harvey~~, P J]]~~	+	[[Category: Harvey PJ]]
-	~~[[Category: Antifungal plant defensin]]~~	+
-	~~[[Category: Antifungal protein~~]]	+

OCA at 11:27, 23 September 2020

2020-09-23T11:27:45Z

←Older revision		Revision as of 11:27, 23 September 2020
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	==Solution structure of antifungal plant defensin PvD1==		==Solution structure of antifungal plant defensin PvD1==
-	<StructureSection load='6vpn' size='340' side='right'caption='[[6vpn]]' scene=''>	+	<StructureSection load='6vpn' size='340' side='right'caption='[[6vpn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VPN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VPN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Phaseolus_vulgaris Phaseolus vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VPN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VPN FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vpn OCA], [http://pdbe.org/6vpn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vpn RCSB], [http://www.ebi.ac.uk/pdbsum/6vpn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vpn ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vpn OCA], [http://pdbe.org/6vpn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vpn RCSB], [http://www.ebi.ac.uk/pdbsum/6vpn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vpn ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Available treatments of invasive fungal infection have limitations including toxicity and the emergence of resistant strains. Therefore, there is an urgent need for alternative solutions. Due to the unique mode of action and high selectivity, plant defensins (PDs) are worthy therapeutic candidates. Chemical synthesis remains a preferred method for the production of many peptide-based therapeutics. Given the relatively long sequence of PDs, as well as their complicated posttranslational modifications, the synthetic route can be considered challenging. Here we describe a total synthesis of PvD1, the defensin from the common bean Phaseolus vulgaris. Analytical, structural and functional characterization revealed that both natural and synthetic peptides fold into a canonical CSalphabeta motif stabilized by conserved disulfide bonds. Moreover, synthetic PvD1 retained the biological activity against four different Candida species and showed no toxicity in-vivo. Adding the high resistance of synthetic PvD1 to proteolytic degradation we claim that conditions are now met to consider plant defensins druggable biologicals.
		+
		+	Synthesis, structure, and activity of the antifungal plant defensin PvD1.,Skalska J, Andrade VM, Cena GL, Harvey PJ, Gaspar DMD, Mello EO, Troeira Henriques S, Valle J, Gomes V, Conceicao K, Castanho MARB, Andreu D J Med Chem. 2020 Aug 6. doi: 10.1021/acs.jmedchem.0c00543. PMID:32787086<ref>PMID:32787086</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6vpn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Harvey PJ]]	+	[[Category: Phaseolus vulgaris]]
		+	[[Category: Harvey, P J]]
		+	[[Category: Antifungal plant defensin]]
		+	[[Category: Antifungal protein]]

OCA at 11:16, 26 August 2020

2020-08-26T11:16:34Z

←Older revision		Revision as of 11:16, 26 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6vpn ~~is ON HOLD until Paper Publication~~	+	==Solution structure of antifungal plant defensin PvD1==
-		+	<StructureSection load='6vpn' size='340' side='right'caption='[[6vpn]]' scene=''>
-	~~Authors~~: ~~Harvey~~, P.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VPN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VPN FirstGlance]. <br>
-	~~Description: Solution structure of antifungal plant defensin PvD1~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vpn OCA], [http://pdbe.org/6vpn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vpn RCSB], [http://www.ebi.ac.uk/pdbsum/6vpn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vpn ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Harvey~~, P.J~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Harvey PJ]]

OCA at 08:25, 18 March 2020

2020-03-18T08:25:48Z

←Older revision		Revision as of 08:25, 18 March 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6vpn is ON HOLD	+	The entry 6vpn is ON HOLD until Paper Publication

	Authors: Harvey, P.J.		Authors: Harvey, P.J.

OCA: Protected "6vpn" [edit=sysop:move=sysop]

2020-02-13T02:45:01Z

Protected "6vpn" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:45, 13 February 2020

OCA: New page: '''Unreleased structure''' The entry 6vpn is ON HOLD Authors: Harvey, P.J. Description: Solution structure of antifungal plant defensin PvD1 Category: Unreleased Structures [[Categ...

2020-02-13T02:44:59Z

New page: '''Unreleased structure''' The entry 6vpn is ON HOLD Authors: Harvey, P.J. Description: Solution structure of antifungal plant defensin PvD1 Category: Unreleased Structures [[Categ...

New page

'''Unreleased structure'''

The entry 6vpn is ON HOLD

Authors: Harvey, P.J.

Description: Solution structure of antifungal plant defensin PvD1
[[Category: Unreleased Structures]]
[[Category: Harvey, P.J]]