6vtu - Revision history

OCA at 08:19, 11 October 2023

2023-10-11T08:19:56Z

←Older revision		Revision as of 08:19, 11 October 2023
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-	====	+	==DH717.1 Fab monomer in complex with man9 glycan==
-	<StructureSection load='6vtu' size='340' side='right'caption='[[6vtu]]' scene=''>	+	<StructureSection load='6vtu' size='340' side='right'caption='[[6vtu]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vtu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VTU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vtu OCA], [https://pdbe.org/6vtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vtu RCSB], [https://www.ebi.ac.uk/pdbsum/6vtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vtu ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.61Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vtu OCA], [https://pdbe.org/6vtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vtu RCSB], [https://www.ebi.ac.uk/pdbsum/6vtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vtu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/S6B291_HUMAN S6B291_HUMAN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated HIV-1 envelope (Env) as a model antigen. 2G12 is a broadly neutralizing Ab (bnAb) that targets a conserved glycan patch on Env of geographically diverse HIV-1 strains using a unique heavy-chain (V(H)) domain-swapped architecture that results in fragment antigen-binding (Fab) dimerization. Here, we describe HIV-1 Env Fab-dimerized glycan (FDG)-reactive bnAbs without V(H)-swapped domains from simian-human immunodeficiency virus (SHIV)-infected macaques. FDG Abs also recognized cell-surface glycans on diverse pathogens, including yeast and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike. FDG precursors were expanded by glycan-bearing immunogens in macaques and were abundant in HIV-1-naive humans. Moreover, FDG precursors were predominately mutated IgM(+)IgD(+)CD27(+), thus suggesting that they originated from a pool of antigen-experienced IgM(+) or marginal zone B cells.
		+
		+	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.,Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF Cell. 2021 May 27;184(11):2955-2972.e25. doi: 10.1016/j.cell.2021.04.042. Epub , 2021 May 20. PMID:34019795<ref>PMID:34019795</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6vtu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Bronkema N]]
		+	[[Category: Fera D]]

OCA at 14:45, 2 June 2021

2021-06-02T14:45:23Z

←Older revision		Revision as of 14:45, 2 June 2021
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	<StructureSection load='6vtu' size='340' side='right'caption='[[6vtu]]' scene=''>		<StructureSection load='6vtu' size='340' side='right'caption='[[6vtu]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6vtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vtu OCA], [~~http~~://pdbe.org/6vtu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6vtu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6vtu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6vtu ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vtu OCA], [https://pdbe.org/6vtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vtu RCSB], [https://www.ebi.ac.uk/pdbsum/6vtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vtu ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 06:44, 30 December 2020

2020-12-30T06:44:17Z

←Older revision		Revision as of 06:44, 30 December 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6vtu ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6vtu' size='340' side='right'caption='[[6vtu]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vtu OCA], [http://pdbe.org/6vtu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vtu RCSB], [http://www.ebi.ac.uk/pdbsum/6vtu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vtu ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 08:21, 27 March 2020

2020-03-27T08:21:05Z

←Older revision		Revision as of 08:21, 27 March 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6vtu is ON HOLD	+	The entry 6vtu is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6vtu" [edit=sysop:move=sysop]

2020-02-19T05:23:26Z

Protected "6vtu" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:23, 19 February 2020

OCA: New page: '''Unreleased structure''' The entry 6vtu is ON HOLD Authors: Description: Category: Unreleased Structures

2020-02-19T05:23:25Z

New page: '''Unreleased structure''' The entry 6vtu is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6vtu is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]