6vwf - Revision history

OCA at 08:22, 11 October 2023

2023-10-11T08:22:07Z

←Older revision		Revision as of 08:22, 11 October 2023
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	<StructureSection load='6vwf' size='340' side='right'caption='[[6vwf]], [[Resolution\|resolution]] 2.64Å' scene=''>		<StructureSection load='6vwf' size='340' side='right'caption='[[6vwf]], [[Resolution\|resolution]] 2.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6vwf]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VWF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6VWF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vwf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VWF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NAD:NICOTINAMIDE~~-~~ADENINE-DINUCLEOTIDE'>NAD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.64Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ALDH9A1, ALDH4, ALDH7, ALDH9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vwf OCA], [~~http~~://pdbe.org/6vwf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6vwf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6vwf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6vwf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vwf OCA], [https://pdbe.org/6vwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vwf RCSB], [https://www.ebi.ac.uk/pdbsum/6vwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vwf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AL9A1_HUMAN AL9A1_HUMAN]] Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.<ref>PMID:10702312</ref>	+	[https://www.uniprot.org/uniprot/AL9A1_HUMAN AL9A1_HUMAN] Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.<ref>PMID:10702312</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6vwf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6vwf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aldehyde dehydrogenase 3D structures\|Aldehyde dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Tanner~~, J J~~]]	+	[[Category: Tanner JJ]]
-	[[Category: Wyatt~~, J W]]~~	+	[[Category: Wyatt JW]]
-	~~[[Category: Aldehyde dehydrogenase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 11:35, 26 August 2020

2020-08-26T11:35:40Z

←Older revision		Revision as of 11:35, 26 August 2020
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	==Structure of ALDH9A1 complexed with NAD+ in space group C222==		==Structure of ALDH9A1 complexed with NAD+ in space group C222==
-	<StructureSection load='6vwf' size='340' side='right'caption='[[6vwf]]' scene=''>	+	<StructureSection load='6vwf' size='340' side='right'caption='[[6vwf]], [[Resolution\|resolution]] 2.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VWF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VWF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vwf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VWF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VWF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vwf OCA], [http://pdbe.org/6vwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vwf RCSB], [http://www.ebi.ac.uk/pdbsum/6vwf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vwf ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALDH9A1, ALDH4, ALDH7, ALDH9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vwf OCA], [http://pdbe.org/6vwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vwf RCSB], [http://www.ebi.ac.uk/pdbsum/6vwf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vwf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AL9A1_HUMAN AL9A1_HUMAN]] Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.<ref>PMID:10702312</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aldehyde dehydrogenase 9A1 (ALDH9A1) is a human enzyme that catalyzes the NAD(+)-dependent oxidation of the carnitine precursor 4-trimethylaminobutyraldehyde to 4-N-trimethylaminobutyrate. Here we show that the broad-spectrum ALDH inhibitor diethylaminobenzaldehyde (DEAB) reversibly inhibits ALDH9A1 in a time-dependent manner. Possible mechanisms of inhibition include covalent reversible inactivation involving the thiohemiacetal intermediate and slow, tight-binding inhibition. Two crystal structures of ALDH9A1 are reported, including the first of the enzyme complexed with NAD(+). One of the structures reveals the active conformation of the enzyme, in which the Rossmann dinucleotide-binding domain is fully ordered and the inter-domain linker adopts the canonical beta-hairpin observed in other ALDH structures. The oligomeric structure of ALDH9A1 was investigated using analytical ultracentrifugation, small-angle X-ray scattering, and negative stain electron microscopy. These data show that ALDH9A1 forms the classic ALDH superfamily dimer-of-dimers tetramer in solution. Our results suggest that the presence of an aldehyde substrate and NAD(+) promotes isomerization of the enzyme into the active conformation.
		+
		+	Inhibition, crystal structures, and in-solution oligomeric structure of aldehyde dehydrogenase 9A1.,Wyatt JW, Korasick DA, Qureshi IA, Campbell AC, Gates KS, Tanner JJ Arch Biochem Biophys. 2020 Jul 24:108477. doi: 10.1016/j.abb.2020.108477. PMID:32717224<ref>PMID:32717224</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6vwf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Tanner JJ]]	+	[[Category: Tanner, J J]]
-	[[Category: Wyatt JW]]	+	[[Category: Wyatt, J W]]
		+	[[Category: Aldehyde dehydrogenase]]
		+	[[Category: Oxidoreductase]]

OCA at 05:34, 5 August 2020

2020-08-05T05:34:44Z

←Older revision		Revision as of 05:34, 5 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6vwf ~~is ON HOLD until Paper Publication~~	+	==Structure of ALDH9A1 complexed with NAD+ in space group C222==
-		+	<StructureSection load='6vwf' size='340' side='right'caption='[[6vwf]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VWF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VWF FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vwf OCA], [http://pdbe.org/6vwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vwf RCSB], [http://www.ebi.ac.uk/pdbsum/6vwf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vwf ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Tanner JJ]]
		+	[[Category: Wyatt JW]]

OCA: Protected "6vwf" [edit=sysop:move=sysop]

2020-02-26T08:14:00Z

Protected "6vwf" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:14, 26 February 2020

OCA: New page: '''Unreleased structure''' The entry 6vwf is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2020-02-26T08:13:59Z

New page: '''Unreleased structure''' The entry 6vwf is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6vwf is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]