6w81 - Revision history

OCA at 14:18, 18 October 2023

2023-10-18T14:18:23Z

←Older revision		Revision as of 14:18, 18 October 2023
Line 1:		Line 1:

	==Structure of PEDV main protease bound to potent broad-spectrum non-covalent inhibitor X77==		==Structure of PEDV main protease bound to potent broad-spectrum non-covalent inhibitor X77==
-	<StructureSection load='6w81' size='340' side='right'caption='[[6w81]]' scene=''>	+	<StructureSection load='6w81' size='340' side='right'caption='[[6w81]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6w81]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_epidemic_diarrhea_virus Porcine epidemic diarrhea virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W81 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w81 OCA], [https://pdbe.org/6w81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w81 RCSB], [https://www.ebi.ac.uk/pdbsum/6w81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w81 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=X77:N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide'>X77</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w81 OCA], [https://pdbe.org/6w81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w81 RCSB], [https://www.ebi.ac.uk/pdbsum/6w81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w81 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A059VJE6_9ALPC A0A059VJE6_9ALPC] Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.[ARBA:ARBA00002928] Nsp9 is a ssRNA-binding protein.[ARBA:ARBA00003140] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3.[ARBA:ARBA00025562]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Porcine epidemic diarrhea virus]]
	[[Category: Mesecar AD]]		[[Category: Mesecar AD]]

OCA at 06:37, 24 March 2021

2021-03-24T06:37:27Z

←Older revision		Revision as of 06:37, 24 March 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6w81 is ON HOLD~~	+	==Structure of PEDV main protease bound to potent broad-spectrum non-covalent inhibitor X77==
-		+	<StructureSection load='6w81' size='340' side='right'caption='[[6w81]]' scene=''>
-	~~Authors: Mesecar, A.D., Center for Structural Genomics of Infectious Diseases (CSGID)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W81 FirstGlance]. <br>
-	~~Description:~~ Structure of PEDV main protease bound to potent broad-spectrum non-covalent inhibitor X77	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w81 OCA], [https://pdbe.org/6w81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w81 RCSB], [https://www.ebi.ac.uk/pdbsum/6w81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w81 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Mesecar~~, A.D]]	+	__TOC__
-	[[Category: ~~Center For Structural Genomics Of Infectious Diseases (Csgid)~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mesecar AD]]

OCA: Protected "6w81" [edit=sysop:move=sysop]

2020-04-01T07:26:33Z

Protected "6w81" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:26, 1 April 2020

OCA: New page: '''Unreleased structure''' The entry 6w81 is ON HOLD Authors: Mesecar, A.D., Center for Structural Genomics of Infectious Diseases (CSGID) Description: Structure of PEDV main protease ...

2020-04-01T07:26:31Z

New page: '''Unreleased structure''' The entry 6w81 is ON HOLD Authors: Mesecar, A.D., Center for Structural Genomics of Infectious Diseases (CSGID) Description: Structure of PEDV main protease ...

New page

'''Unreleased structure'''

The entry 6w81 is ON HOLD

Authors: Mesecar, A.D., Center for Structural Genomics of Infectious Diseases (CSGID)

Description: Structure of PEDV main protease bound to potent broad-spectrum non-covalent inhibitor X77
[[Category: Unreleased Structures]]
[[Category: Mesecar, A.D]]
[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]