6wik - Revision history

OCA at 19:42, 7 September 2022

2022-09-07T19:42:27Z

←Older revision		Revision as of 19:42, 7 September 2022
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-	====	+	==Cryo-EM structure of SLC40/ferroportin with Fab in the presence of hepcidin==
-	<StructureSection load='6wik' size='340' side='right'caption='[[6wik]]' scene=''>	+	<StructureSection load='6wik' size='340' side='right'caption='[[6wik]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wik]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Carlito_syrichta Carlito syrichta] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WIK FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wik OCA], [https://pdbe.org/6wik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wik RCSB], [https://www.ebi.ac.uk/pdbsum/6wik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wik ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wik OCA], [https://pdbe.org/6wik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wik RCSB], [https://www.ebi.ac.uk/pdbsum/6wik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wik ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/A0A1U7U6F1_CARSF A0A1U7U6F1_CARSF]] May be involved in iron transport and iron homeostasis.[RuleBase:RU365065]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin is inhibited by a peptide hormone, hepcidin. In humans, mutations in ferroportin lead to ferroportin diseases that are often associated with accumulation of iron in macrophages and symptoms of iron deficiency anemia. Here we present the structures of the ferroportin from the primate Philippine tarsier (TsFpn) in the presence and absence of hepcidin solved by cryo-electron microscopy. TsFpn is composed of two domains resembling a clamshell and the structure defines two metal ion binding sites, one in each domain. Both structures are in an outward-facing conformation, and hepcidin binds between the two domains and reaches one of the ion binding sites. Functional studies show that TsFpn is an electroneutral H(+)/Fe(2+) antiporter so that transport of each Fe(2+) is coupled to transport of two H(+) in the opposite direction. Perturbing either of the ion binding sites compromises the coupled transport of H(+) and Fe(2+). These results establish the structural basis of metal ion binding, transport and inhibition in ferroportin and provide a blueprint for targeting ferroportin in pharmacological intervention of ferroportin diseases.
		+
		+	Structural basis of ion transport and inhibition in ferroportin.,Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M Nat Commun. 2020 Nov 10;11(1):5686. doi: 10.1038/s41467-020-19458-6. PMID:33173040<ref>PMID:33173040</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6wik" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Carlito syrichta]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z~~-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Gao S]]
		+	[[Category: Pan Y]]
		+	[[Category: Ren Z]]
		+	[[Category: Shen J]]
		+	[[Category: Yan N]]
		+	[[Category: Zhou M]]

OCA at 06:41, 31 August 2022

2022-08-31T06:41:12Z

←Older revision		Revision as of 06:41, 31 August 2022
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	<StructureSection load='6wik' size='340' side='right'caption='[[6wik]]' scene=''>		<StructureSection load='6wik' size='340' side='right'caption='[[6wik]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6wik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wik OCA], [~~http~~://pdbe.org/6wik PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6wik RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6wik PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6wik ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wik OCA], [https://pdbe.org/6wik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wik RCSB], [https://www.ebi.ac.uk/pdbsum/6wik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wik ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 07:59, 11 November 2020

2020-11-11T07:59:37Z

←Older revision		Revision as of 07:59, 11 November 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6wik ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6wik' size='340' side='right'caption='[[6wik]]' scene=''>
-	~~Authors~~: ~~Shen, J~~.~~, Ren, Z~~.~~, Pan, Y~~.~~, Gao, S~~.~~, Yan, N~~.~~, Zhou, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Cryo-EM structure of SLC40~~/~~ferroportin with Fab in the presence of hepcidin~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wik OCA], [http://pdbe.org/6wik PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wik RCSB], [http://www.ebi.ac.uk/pdbsum/6wik PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wik ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Gao, S~~]]	+	__TOC__
-	[~~[Category~~: ~~Yan, N]~~]	+	</StructureSection>
-	[~~[Category~~: ~~Ren, Z~~]]	+	[[Category: Large Structures]]
-	[~~[Category~~: ~~Pan~~, Y]]	+	[[Category: Z-disk]]
-	[[Category: ~~Zhou, M~~]]	+
-	[[Category: ~~Shen, J~~]]	+

OCA at 03:47, 5 August 2020

2020-08-05T03:47:56Z

←Older revision		Revision as of 03:47, 5 August 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6wik is ON HOLD	+	The entry 6wik is ON HOLD until Paper Publication

	Authors: Shen, J., Ren, Z., Pan, Y., Gao, S., Yan, N., Zhou, M.		Authors: Shen, J., Ren, Z., Pan, Y., Gao, S., Yan, N., Zhou, M.
Line 9:		Line 9:
	[[Category: Gao, S]]		[[Category: Gao, S]]
	[[Category: Yan, N]]		[[Category: Yan, N]]
-	[[Category: Pan, Y]]
	[[Category: Ren, Z]]		[[Category: Ren, Z]]
		+	[[Category: Pan, Y]]
	[[Category: Zhou, M]]		[[Category: Zhou, M]]
	[[Category: Shen, J]]		[[Category: Shen, J]]

OCA at 10:37, 8 July 2020

2020-07-08T10:37:35Z

←Older revision		Revision as of 10:37, 8 July 2020
Line 5:		Line 5:
	Authors: Shen, J., Ren, Z., Pan, Y., Gao, S., Yan, N., Zhou, M.		Authors: Shen, J., Ren, Z., Pan, Y., Gao, S., Yan, N., Zhou, M.

-	Description: Cryo-EM structure of SLC40/ferroportin with Fab in presence of hepcidin	+	Description: Cryo-EM structure of SLC40/ferroportin with Fab in the presence of hepcidin
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Gao, S]]		[[Category: Gao, S]]
	[[Category: Yan, N]]		[[Category: Yan, N]]
-	[[Category: Ren, Z]]
	[[Category: Pan, Y]]		[[Category: Pan, Y]]
		+	[[Category: Ren, Z]]
	[[Category: Zhou, M]]		[[Category: Zhou, M]]
	[[Category: Shen, J]]		[[Category: Shen, J]]

OCA: Protected "6wik" [edit=sysop:move=sysop]

2020-04-15T05:30:18Z

Protected "6wik" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:30, 15 April 2020

OCA: New page: '''Unreleased structure''' The entry 6wik is ON HOLD Authors: Shen, J., Ren, Z., Pan, Y., Gao, S., Yan, N., Zhou, M. Description: Cryo-EM structure of SLC40/ferroportin with Fab in pre...

2020-04-15T05:30:16Z

New page: '''Unreleased structure''' The entry 6wik is ON HOLD Authors: Shen, J., Ren, Z., Pan, Y., Gao, S., Yan, N., Zhou, M. Description: Cryo-EM structure of SLC40/ferroportin with Fab in pre...

New page

'''Unreleased structure'''

The entry 6wik is ON HOLD

Authors: Shen, J., Ren, Z., Pan, Y., Gao, S., Yan, N., Zhou, M.

Description: Cryo-EM structure of SLC40/ferroportin with Fab in presence of hepcidin
[[Category: Unreleased Structures]]
[[Category: Gao, S]]
[[Category: Yan, N]]
[[Category: Ren, Z]]
[[Category: Pan, Y]]
[[Category: Zhou, M]]
[[Category: Shen, J]]