OCA at 14:32, 18 October 2023

2023-10-18T14:32:47Z

←Older revision		Revision as of 14:32, 18 October 2023
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	==AvaR1 bound to Avenolide==		==AvaR1 bound to Avenolide==
-	<StructureSection load='6wp9' size='340' side='right'caption='[[6wp9]]' scene=''>	+	<StructureSection load='6wp9' size='340' side='right'caption='[[6wp9]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WP9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6WP9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wp9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_avermitilis_MA-4680_=_NBRC_14893 Streptomyces avermitilis MA-4680 = NBRC 14893]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WP9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6wp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wp9 OCA], [~~http~~://pdbe.org/6wp9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6wp9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6wp9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6wp9 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XVR:(5S)-5-[(6R)-6-hydroxy-6-methyl-5-oxooctyl]furan-2(5H)-one'>XVR</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wp9 OCA], [https://pdbe.org/6wp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wp9 RCSB], [https://www.ebi.ac.uk/pdbsum/6wp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wp9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q82H41_STRAW Q82H41_STRAW]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Diffusible small molecule microbial hormones drastically alter the expression profiles of antibiotics and other drugs in actinobacteria. For example, avenolide (a butenolide) regulates production of avermectin, derivatives of which are used in the treatment of river blindness and other parasitic diseases. Butenolides and gamma-butyrolactones control production of pharmaceutically important secondary metabolites by binding to TetR family transcriptional repressors. Here, we describe a concise, 22-step synthetic strategy for the production of avenolide. We present crystal structures of the butenolide receptor AvaR1 in isolation, and in complex with avenolide, as well as AvaR1 bound to an oligonucleotide derived from its operator. Biochemical studies guided by the co-crystal structures enable identification of 90 new actinobacteria that may be regulated by butenolides, two of which are experimentally verified. These studies provide a foundation for understanding regulation of microbial secondary metabolite production, which may be exploited for the discovery and production of novel medicines.
		+
		+	Biochemical basis for the regulation of biosynthesis of antiparasitics by bacterial hormones.,Kapoor I, Olivares P, Nair SK Elife. 2020 Jun 8;9. pii: 57824. doi: 10.7554/eLife.57824. PMID:32510324<ref>PMID:32510324</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6wp9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Streptomyces avermitilis MA-4680 = NBRC 14893]]
	[[Category: Kapoor I]]		[[Category: Kapoor I]]
	[[Category: Nair SK]]		[[Category: Nair SK]]
	[[Category: Olivares PJ]]		[[Category: Olivares PJ]]

OCA at 10:53, 22 July 2020

2020-07-22T10:53:37Z

←Older revision		Revision as of 10:53, 22 July 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6wp9 is ~~ON HOLD~~	+	==AvaR1 bound to Avenolide==
-		+	<StructureSection load='6wp9' size='340' side='right'caption='[[6wp9]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WP9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WP9 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wp9 OCA], [http://pdbe.org/6wp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wp9 RCSB], [http://www.ebi.ac.uk/pdbsum/6wp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wp9 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kapoor I]]
		+	[[Category: Nair SK]]
		+	[[Category: Olivares PJ]]

OCA: Protected "6wp9" [edit=sysop:move=sysop]

2020-05-06T04:28:25Z

Protected "6wp9" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:28, 6 May 2020

OCA: New page: '''Unreleased structure''' The entry 6wp9 is ON HOLD Authors: Description: Category: Unreleased Structures

2020-05-06T04:28:24Z

New page: '''Unreleased structure''' The entry 6wp9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6wp9 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6wp9 - Revision history

OCA at 14:32, 18 October 2023

OCA at 10:53, 22 July 2020

OCA: Protected "6wp9" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6wp9 is ON HOLD Authors: Description: Category: Unreleased Structures