6wql - Revision history

OCA at 11:06, 14 June 2023

2023-06-14T11:06:49Z

←Older revision		Revision as of 11:06, 14 June 2023
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	==Solution structure of the seed peptide C2 (VBP-1) from pumpkin==		==Solution structure of the seed peptide C2 (VBP-1) from pumpkin==
-	<StructureSection load='6wql' size='340' side='right'caption='[[6wql~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6wql' size='340' side='right'caption='[[6wql]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6wql]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WQL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6WQL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wql]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WQL FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6wqj\|6wqj]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wql OCA], [https://pdbe.org/6wql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wql RCSB], [https://www.ebi.ac.uk/pdbsum/6wql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wql ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6wql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wql OCA], [~~http~~://pdbe.org/6wql PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6wql RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6wql PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6wql ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9ZWI3_CUCMA Q9ZWI3_CUCMA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cucurbita maxima]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Payne~~, C P~~]]	+	[[Category: Payne CP]]
-	[[Category: Rosengren~~, K J]]~~	+	[[Category: Rosengren KJ]]
-	~~[[Category: Plant protein]]~~	+
-	~~[[Category: Vicilin-buried peptide~~]]	+

OCA at 07:37, 4 November 2020

2020-11-04T07:37:12Z

←Older revision		Revision as of 07:37, 4 November 2020
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	==Solution structure of the seed peptide C2 (VBP-1) from pumpkin==		==Solution structure of the seed peptide C2 (VBP-1) from pumpkin==
-	<StructureSection load='6wql' size='340' side='right'caption='[[6wql]]' scene=''>	+	<StructureSection load='6wql' size='340' side='right'caption='[[6wql]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WQL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WQL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wql]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WQL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WQL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wql OCA], [http://pdbe.org/6wql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wql RCSB], [http://www.ebi.ac.uk/pdbsum/6wql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wql ProSAT]</span></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6wqj\|6wqj]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wql OCA], [http://pdbe.org/6wql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wql RCSB], [http://www.ebi.ac.uk/pdbsum/6wql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wql ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plants and their seeds have been shown to be a rich source of cystine-stabilized peptides. Recently a new family of plant seed peptides whose sequences are buried within precursors for seed storage vicilins was identified. Members of this Vicilin-Buried Peptide (VBP) family are found in distantly related plant species including the monocot date palm, as well as dicotyledonous species like pumpkin and sesame. Genetic evidence for their widespread occurrence indicates that they are of ancient origin. Limited structural studies have been conducted on VBP family members, but two members have been shown to adopt a helical hairpin fold. We present an extensive characterization of VBPs using solution NMR spectroscopy, to better understand their structural features. Four peptides were produced by solid phase peptide synthesis and shown to favor a helix-loop-helix hairpin fold, as a result of the I-IV/II-III ladderlike connectivity of their disulfide bonds. Interhelical interactions, including hydrophobic contacts and salt bridges, are critical for the fold stability and control the angle at which the antiparallel alpha-helices interface. Activities reported for VBPs include trypsin inhibitory activity and inhibition of ribosomal function; however, their diverse structural features despite a common fold suggest that additional bioactivities yet to be revealed are likely.
		+
		+	Defining the Familial Fold of the Vicilin-Buried Peptide Family.,Payne CD, Vadlamani G, Fisher MF, Zhang J, Clark RJ, Mylne JS, Rosengren KJ J Nat Prod. 2020 Sep 30. doi: 10.1021/acs.jnatprod.0c00594. PMID:32997497<ref>PMID:32997497</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6wql" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Payne CP]]	+	[[Category: Payne, C P]]
-	[[Category: Rosengren KJ]]	+	[[Category: Rosengren, K J]]
		+	[[Category: Plant protein]]
		+	[[Category: Vicilin-buried peptide]]

OCA at 08:15, 21 October 2020

2020-10-21T08:15:09Z

←Older revision		Revision as of 08:15, 21 October 2020
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-	'''Unreleased structure'''

-	~~The entry 6wql is ON HOLD until Paper Publication~~	+	==Solution structure of the seed peptide C2 (VBP-1) from pumpkin==
-		+	<StructureSection load='6wql' size='340' side='right'caption='[[6wql]]' scene=''>
-	~~Authors: Payne, C.P., Rosengren, K.J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WQL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WQL FirstGlance]. <br>
-	~~Description:~~ Solution structure of the seed peptide C2 (VBP-1) from pumpkin	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wql OCA], [http://pdbe.org/6wql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wql RCSB], [http://www.ebi.ac.uk/pdbsum/6wql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wql ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Rosengren~~, K.J]]	+	__TOC__
-	[[Category: Payne~~, C.P~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Payne CP]]
		+	[[Category: Rosengren KJ]]

OCA at 05:09, 3 June 2020

2020-06-03T05:09:17Z

←Older revision		Revision as of 05:09, 3 June 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6wql is ON HOLD	+	The entry 6wql is ON HOLD until Paper Publication

	Authors: Payne, C.P., Rosengren, K.J.		Authors: Payne, C.P., Rosengren, K.J.

OCA: Protected "6wql" [edit=sysop:move=sysop]

2020-05-06T04:31:43Z

Protected "6wql" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:31, 6 May 2020

OCA: New page: '''Unreleased structure''' The entry 6wql is ON HOLD Authors: Payne, C.P., Rosengren, K.J. Description: Solution structure of the seed peptide C2 (VBP-1) from pumpkin [[Category: Unrel...

2020-05-06T04:31:42Z

New page: '''Unreleased structure''' The entry 6wql is ON HOLD Authors: Payne, C.P., Rosengren, K.J. Description: Solution structure of the seed peptide C2 (VBP-1) from pumpkin [[Category: Unrel...

New page

'''Unreleased structure'''

The entry 6wql is ON HOLD

Authors: Payne, C.P., Rosengren, K.J.

Description: Solution structure of the seed peptide C2 (VBP-1) from pumpkin
[[Category: Unreleased Structures]]
[[Category: Rosengren, K.J]]
[[Category: Payne, C.P]]