OCA at 14:48, 6 March 2024

2024-03-06T14:48:08Z

←Older revision		Revision as of 14:48, 6 March 2024
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	==hEAAT3-IFS-Na==		==hEAAT3-IFS-Na==
-	<StructureSection load='6x2l' size='340' side='right'caption='[[6x2l]]' scene=''>	+	<StructureSection load='6x2l' size='340' side='right'caption='[[6x2l]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X2L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6x2l]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X2L FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x2l OCA], [https://pdbe.org/6x2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x2l RCSB], [https://www.ebi.ac.uk/pdbsum/6x2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x2l ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.85Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x2l OCA], [https://pdbe.org/6x2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x2l RCSB], [https://www.ebi.ac.uk/pdbsum/6x2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x2l ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/EAA3_HUMAN EAA3_HUMAN] Hot water reflex epilepsy;Dicarboxylic aminoaciduria. The disease is caused by variants affecting the gene represented in this entry. Disease susceptibility is associated with variants affecting the gene represented in this entry. A deletion at the chromosome 9p24.2 locus, including SLC1A1, has been identified in patients with psychotic disorders (PubMed:21982423). This 84 kb deletion is immediately upstream of the SLC1A1 gene in a regulatory region that contains the full native promoter sequence, extends through exon 1 of the SLC1A1 mRNA, co-segregates with disease in an extended 5-generation pedigree and increases disease risk more than 18-fold for family members (PubMed:23341099).<ref>PMID:21982423</ref> <ref>PMID:23341099</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EAA3_HUMAN EAA3_HUMAN] Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949, PubMed:33658209). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:33658209). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity).[UniProtKB:P51906][UniProtKB:P51907]<ref>PMID:21123949</ref> <ref>PMID:26690923</ref> <ref>PMID:33658209</ref> <ref>PMID:7521911</ref> <ref>PMID:7914198</ref> <ref>PMID:8857541</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Boudker O]]		[[Category: Boudker O]]
	[[Category: Matthies D]]		[[Category: Matthies D]]
	[[Category: Qiu B]]		[[Category: Qiu B]]

OCA at 06:42, 17 March 2021

2021-03-17T06:42:53Z

←Older revision		Revision as of 06:42, 17 March 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6x2l is ~~ON HOLD until Paper Publication~~	+	==hEAAT3-IFS-Na==
-		+	<StructureSection load='6x2l' size='340' side='right'caption='[[6x2l]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X2L FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x2l OCA], [https://pdbe.org/6x2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x2l RCSB], [https://www.ebi.ac.uk/pdbsum/6x2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x2l ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Boudker O]]
		+	[[Category: Matthies D]]
		+	[[Category: Qiu B]]

OCA at 18:20, 24 June 2020

2020-06-24T18:20:32Z

←Older revision		Revision as of 18:20, 24 June 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6x2l is ON HOLD	+	The entry 6x2l is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6x2l" [edit=sysop:move=sysop]

2020-05-27T04:55:38Z

Protected "6x2l" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:55, 27 May 2020

OCA: New page: '''Unreleased structure''' The entry 6x2l is ON HOLD Authors: Description: Category: Unreleased Structures

2020-05-27T04:55:36Z

New page: '''Unreleased structure''' The entry 6x2l is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6x2l is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6x2l - Revision history

OCA at 14:48, 6 March 2024

OCA at 06:42, 17 March 2021

OCA at 18:20, 24 June 2020

OCA: Protected "6x2l" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6x2l is ON HOLD Authors: Description: Category: Unreleased Structures