6x7i - Revision history

OCA at 11:07, 14 June 2023

2023-06-14T11:07:09Z

←Older revision		Revision as of 11:07, 14 June 2023
Line 3:		Line 3:
	<StructureSection load='6x7i' size='340' side='right'caption='[[6x7i]]' scene=''>		<StructureSection load='6x7i' size='340' side='right'caption='[[6x7i]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X7I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6x7i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X7I FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x7i OCA], [https://pdbe.org/6x7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x7i RCSB], [https://www.ebi.ac.uk/pdbsum/6x7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x7i ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x7i OCA], [https://pdbe.org/6x7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x7i RCSB], [https://www.ebi.ac.uk/pdbsum/6x7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x7i ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bcl-xL is a major inhibitor of apoptosis, a fundamental homeostatic process of programmed cell death that is highly conserved across evolution. Because it plays prominent roles in cancer, Bcl-xL is a major target for anticancer therapy and for studies aimed at understanding its structure and activity. Although Bcl-xL is active primarily at intracellular membranes, most studies have focused on soluble forms of the protein lacking both the membrane-anchoring C-terminal tail and the intrinsically disordered loop, and this has resulted in a fragmented view of the protein's biological activity. Here, we describe the conformation of full-length Bcl-xL. Using NMR spectroscopy, molecular dynamics simulations, and isothermal titration calorimetry, we show how the three structural elements affect the protein's structure, dynamics, and ligand-binding activity in both its soluble and membrane-anchored states. The combined data provide information about the molecular basis for the protein's functionality and a view of its complex molecular mechanisms.
		+
		+	Conformational States of the Cytoprotective Protein Bcl-xL.,Ryzhov P, Tian Y, Yao Y, Bobkov AA, Im W, Marassi FM Biophys J. 2020 Oct 6;119(7):1324-1334. doi: 10.1016/j.bpj.2020.08.014. Epub 2020, Aug 20. PMID:32888404<ref>PMID:32888404</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6x7i" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]		*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Marassi FM]]		[[Category: Marassi FM]]
	[[Category: Tian Y]]		[[Category: Tian Y]]
	[[Category: Yao Y]]		[[Category: Yao Y]]

OCA at 07:34, 19 January 2022

2022-01-19T07:34:16Z

←Older revision		Revision as of 07:34, 19 January 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 6x7i is ~~ON HOLD~~	+	==Structure of the C-terminal domain of BCL-XL in membrane==
		+	<StructureSection load='6x7i' size='340' side='right'caption='[[6x7i]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X7I FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x7i OCA], [https://pdbe.org/6x7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x7i RCSB], [https://www.ebi.ac.uk/pdbsum/6x7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x7i ProSAT]</span></td></tr>
		+	</table>

-	~~Authors: Yao, Y., Tian, Y., Marassi, F.M.~~	+	==See Also==
-		+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
-	~~Description: Structure of the C~~-~~terminal domain of BCL~~-~~XL in membrane~~	+	__TOC__
-	[[Category: ~~Unreleased~~ Structures]]	+	</StructureSection>
-	[[Category: Marassi~~, F.M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Yao,~~ Y]]	+	[[Category: Marassi FM]]
-	[[Category: ~~Tian,~~ Y]]	+	[[Category: Tian Y]]
		+	[[Category: Yao Y]]

OCA: Protected "6x7i" [edit=sysop:move=sysop]

2020-06-10T04:57:25Z

Protected "6x7i" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:57, 10 June 2020

OCA: New page: '''Unreleased structure''' The entry 6x7i is ON HOLD Authors: Yao, Y., Tian, Y., Marassi, F.M. Description: Structure of the C-terminal domain of BCL-XL in membrane [[Category: Unrelea...

2020-06-10T04:57:24Z

New page: '''Unreleased structure''' The entry 6x7i is ON HOLD Authors: Yao, Y., Tian, Y., Marassi, F.M. Description: Structure of the C-terminal domain of BCL-XL in membrane [[Category: Unrelea...

New page

'''Unreleased structure'''

The entry 6x7i is ON HOLD

Authors: Yao, Y., Tian, Y., Marassi, F.M.

Description: Structure of the C-terminal domain of BCL-XL in membrane
[[Category: Unreleased Structures]]
[[Category: Marassi, F.M]]
[[Category: Yao, Y]]
[[Category: Tian, Y]]