6x94 - Revision history

OCA at 14:47, 18 October 2023

2023-10-18T14:47:18Z

←Older revision		Revision as of 14:47, 18 October 2023
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	==An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli==		==An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli==
-	<StructureSection load='6x94' size='340' side='right'caption='[[6x94]]' scene=''>	+	<StructureSection load='6x94' size='340' side='right'caption='[[6x94]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X94 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6X94 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6x94]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_mazei_Go1 Methanosarcina mazei Go1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X94 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6x94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x94 OCA], [~~http~~://pdbe.org/6x94 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6x94 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6x94 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6x94 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SSA:5-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE'>SSA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x94 OCA], [https://pdbe.org/6x94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x94 RCSB], [https://www.ebi.ac.uk/pdbsum/6x94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x94 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SYS_METMA SYS_METMA] Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).[HAMAP-Rule:MF_00176]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We report the development of the orthogonal amber-suppressor pair Archaeoglobus fulgidus seryl-tRNA (Af-tRNA(Ser))/Methanosarcina mazei seryl-tRNA synthetase (MmSerRS) in Escherichia coli. Furthermore, the crystal structure of MmSerRS was solved at 1.45 A resolution, which should enable structure-guided engineering of its active site to genetically encode small, polar noncanonical amino acids (ncAAs).
		+
		+	An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli.,Zambaldo C, Koh M, Nasertorabi F, Han GW, Chatterjee A, Stevens RC, Schultz PG Bioorg Med Chem. 2020 Oct 15;28(20):115662. doi: 10.1016/j.bmc.2020.115662. Epub , 2020 Jul 28. PMID:33069069<ref>PMID:33069069</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6x94" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Methanosarcina mazei Go1]]
	[[Category: Chatterjee A]]		[[Category: Chatterjee A]]
	[[Category: Han GW]]		[[Category: Han GW]]

OCA at 07:23, 4 November 2020

2020-11-04T07:23:06Z

←Older revision		Revision as of 07:23, 4 November 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6x94 is ~~ON HOLD until Paper Publication~~	+	==An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli==
-		+	<StructureSection load='6x94' size='340' side='right'caption='[[6x94]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X94 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6X94 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6x94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x94 OCA], [http://pdbe.org/6x94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6x94 RCSB], [http://www.ebi.ac.uk/pdbsum/6x94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6x94 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chatterjee A]]
		+	[[Category: Han GW]]
		+	[[Category: Koh M]]
		+	[[Category: Nasertorabi F]]
		+	[[Category: Schultz PG]]
		+	[[Category: Stevens RC]]
		+	[[Category: Zambaldo C]]

OCA at 08:38, 17 June 2020

2020-06-17T08:38:00Z

←Older revision		Revision as of 08:38, 17 June 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6x94 is ON HOLD	+	The entry 6x94 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6x94" [edit=sysop:move=sysop]

2020-06-10T05:00:10Z

Protected "6x94" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:00, 10 June 2020

OCA: New page: '''Unreleased structure''' The entry 6x94 is ON HOLD Authors: Description: Category: Unreleased Structures

2020-06-10T05:00:08Z

New page: '''Unreleased structure''' The entry 6x94 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6x94 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]