6xau - Revision history

OCA at 14:48, 18 October 2023

2023-10-18T14:48:57Z

←Older revision		Revision as of 14:48, 18 October 2023
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	<StructureSection load='6xau' size='340' side='right'caption='[[6xau]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='6xau' size='340' side='right'caption='[[6xau]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6xau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAU FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Mecom~~, ~~Evi1, Mds1, Prdm3 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.89Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xau OCA], [https://pdbe.org/6xau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xau RCSB], [https://www.ebi.ac.uk/pdbsum/6xau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xau ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xau OCA], [https://pdbe.org/6xau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xau RCSB], [https://www.ebi.ac.uk/pdbsum/6xau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xau ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MECOM_MOUSE MECOM_MOUSE]] Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.<ref>PMID:15889140</ref> <ref>PMID:18619962</ref> <ref>PMID:19767769</ref> Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.<ref>PMID:22939622</ref>	+	[https://www.uniprot.org/uniprot/MECOM_MOUSE MECOM_MOUSE] Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.<ref>PMID:15889140</ref> <ref>PMID:18619962</ref> <ref>PMID:19767769</ref> Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.<ref>PMID:22939622</ref>
		+
		+	==See Also==
		+	*[[Histone methyltransferase 3D structures\|Histone methyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Briknarova, K]]	+	[[Category: Briknarova K]]
-	[[Category: Loa, S]]	+	[[Category: Loa S]]
-	[[Category: Mou~~, T C~~]]	+	[[Category: Mou TC]]
-	[[Category: Sprang~~, S R]]~~	+	[[Category: Sprang SR]]
-	~~[[Category: Prdm3]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 07:42, 25 June 2021

2021-06-25T07:42:43Z

←Older revision		Revision as of 07:42, 25 June 2021
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	==Structure of the PR domain from PRDM3==		==Structure of the PR domain from PRDM3==
-	<StructureSection load='6xau' size='340' side='right'caption='[[6xau]]' scene=''>	+	<StructureSection load='6xau' size='340' side='right'caption='[[6xau]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xau OCA], [https://pdbe.org/6xau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xau RCSB], [https://www.ebi.ac.uk/pdbsum/6xau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xau ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mecom, Evi1, Mds1, Prdm3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xau OCA], [https://pdbe.org/6xau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xau RCSB], [https://www.ebi.ac.uk/pdbsum/6xau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xau ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/MECOM_MOUSE MECOM_MOUSE]] Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.<ref>PMID:15889140</ref> <ref>PMID:18619962</ref> <ref>PMID:19767769</ref> Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.<ref>PMID:22939622</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Briknarova K]]	+	[[Category: Lk3 transgenic mice]]
-	[[Category: Loa S]]	+	[[Category: Briknarova, K]]
-	[[Category: Mou TC]]	+	[[Category: Loa, S]]
-	[[Category: Sprang SR]]	+	[[Category: Mou, T C]]
		+	[[Category: Sprang, S R]]
		+	[[Category: Prdm3]]
		+	[[Category: Transcription]]

OCA at 12:09, 9 June 2021

2021-06-09T12:09:40Z

←Older revision		Revision as of 12:09, 9 June 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6xau ~~is ON HOLD until Jun 04 2022~~	+	==Structure of the PR domain from PRDM3==
-		+	<StructureSection load='6xau' size='340' side='right'caption='[[6xau]]' scene=''>
-	~~Authors~~: ~~Mou~~, T.C., ~~Loa~~, S., ~~Sprang, S~~.R., ~~Briknarova, K~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAU FirstGlance]. <br>
-	~~Description: Structure of the PR domain from PRDM3~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xau OCA], [https://pdbe.org/6xau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xau RCSB], [https://www.ebi.ac.uk/pdbsum/6xau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xau ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Loa, S~~]]	+	__TOC__
-	[[Category: ~~Mou, T.C~~]]	+	</StructureSection>
-	[[Category: ~~Briknarova, K~~]]	+	[[Category: Large Structures]]
-	[[Category: Sprang~~, S.R~~]]	+	[[Category: Briknarova K]]
		+	[[Category: Loa S]]
		+	[[Category: Mou TC]]
		+	[[Category: Sprang SR]]

OCA at 18:22, 24 June 2020

2020-06-24T18:22:42Z

←Older revision		Revision as of 18:22, 24 June 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6xau is ON HOLD	+	The entry 6xau is ON HOLD until Jun 04 2022

	Authors: Mou, T.C., Loa, S., Sprang, S.R., Briknarova, K.		Authors: Mou, T.C., Loa, S., Sprang, S.R., Briknarova, K.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Loa, S]]		[[Category: Loa, S]]
-	[[Category: Briknarova, K]]
	[[Category: Mou, T.C]]		[[Category: Mou, T.C]]
		+	[[Category: Briknarova, K]]
	[[Category: Sprang, S.R]]		[[Category: Sprang, S.R]]

OCA: Protected "6xau" [edit=sysop:move=sysop]

2020-06-10T05:04:23Z

Protected "6xau" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:04, 10 June 2020

OCA: New page: '''Unreleased structure''' The entry 6xau is ON HOLD Authors: Mou, T.C., Loa, S., Sprang, S.R., Briknarova, K. Description: Structure of the PR domain from PRDM3 [[Category: Unreleased...

2020-06-10T05:04:22Z

New page: '''Unreleased structure''' The entry 6xau is ON HOLD Authors: Mou, T.C., Loa, S., Sprang, S.R., Briknarova, K. Description: Structure of the PR domain from PRDM3 [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 6xau is ON HOLD

Authors: Mou, T.C., Loa, S., Sprang, S.R., Briknarova, K.

Description: Structure of the PR domain from PRDM3
[[Category: Unreleased Structures]]
[[Category: Loa, S]]
[[Category: Briknarova, K]]
[[Category: Mou, T.C]]
[[Category: Sprang, S.R]]