6xaz - Revision history

OCA at 14:49, 18 October 2023

2023-10-18T14:49:12Z

←Older revision		Revision as of 14:49, 18 October 2023
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	<StructureSection load='6xaz' size='340' side='right'caption='[[6xaz]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='6xaz' size='340' side='right'caption='[[6xaz]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6xaz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xaz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PRDM5, PFM2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]~~)</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xaz OCA], [https://pdbe.org/6xaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xaz RCSB], [https://www.ebi.ac.uk/pdbsum/6xaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xaz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xaz OCA], [https://pdbe.org/6xaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xaz RCSB], [https://www.ebi.ac.uk/pdbsum/6xaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xaz ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/PRDM5_HUMAN PRDM5_HUMAN]] Brittle cornea syndrome. The disease is caused by variants affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/PRDM5_HUMAN PRDM5_HUMAN] Brittle cornea syndrome. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PRDM5_HUMAN PRDM5_HUMAN]] Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.<ref>PMID:15077163</ref> <ref>PMID:17636019</ref> <ref>PMID:21664999</ref>	+	[https://www.uniprot.org/uniprot/PRDM5_HUMAN PRDM5_HUMAN] Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.<ref>PMID:15077163</ref> <ref>PMID:17636019</ref> <ref>PMID:21664999</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Briknarova, K]]	+	[[Category: Briknarova K]]
-	[[Category: Kerchner~~, K M~~]]	+	[[Category: Kerchner KM]]
-	[[Category: Mou~~, T C~~]]	+	[[Category: Mou TC]]
-	[[Category: Sprang~~, S R]]~~	+	[[Category: Sprang SR]]
-	~~[[Category: Prdm5]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:42, 25 June 2021

2021-06-25T07:42:58Z

←Older revision		Revision as of 07:42, 25 June 2021
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	==Structure of the PR domain from human PRDM5==		==Structure of the PR domain from human PRDM5==
-	<StructureSection load='6xaz' size='340' side='right'caption='[[6xaz]]' scene=''>	+	<StructureSection load='6xaz' size='340' side='right'caption='[[6xaz]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xaz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xaz OCA], [https://pdbe.org/6xaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xaz RCSB], [https://www.ebi.ac.uk/pdbsum/6xaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xaz ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRDM5, PFM2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xaz OCA], [https://pdbe.org/6xaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xaz RCSB], [https://www.ebi.ac.uk/pdbsum/6xaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xaz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/PRDM5_HUMAN PRDM5_HUMAN]] Brittle cornea syndrome. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/PRDM5_HUMAN PRDM5_HUMAN]] Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.<ref>PMID:15077163</ref> <ref>PMID:17636019</ref> <ref>PMID:21664999</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Briknarova K]]	+	[[Category: Briknarova, K]]
-	[[Category: Kerchner KM]]	+	[[Category: Kerchner, K M]]
-	[[Category: Mou TC]]	+	[[Category: Mou, T C]]
-	[[Category: Sprang SR]]	+	[[Category: Sprang, S R]]
		+	[[Category: Prdm5]]
		+	[[Category: Transcription]]
		+	[[Category: Transferase]]

OCA at 12:09, 9 June 2021

2021-06-09T12:09:48Z

←Older revision		Revision as of 12:09, 9 June 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6xaz ~~is ON HOLD until Jun 05 2022~~	+	==Structure of the PR domain from human PRDM5==
-		+	<StructureSection load='6xaz' size='340' side='right'caption='[[6xaz]]' scene=''>
-	~~Authors~~: ~~Mou~~, T.C., ~~Kerchner~~, K.M., ~~Sprang, S~~.R., ~~Briknarova, K~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAZ FirstGlance]. <br>
-	~~Description: Structure of the PR domain from human PRDM5~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xaz OCA], [https://pdbe.org/6xaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xaz RCSB], [https://www.ebi.ac.uk/pdbsum/6xaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xaz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Mou, T.C~~]]	+	__TOC__
-	[[Category: ~~Briknarova, K~~]]	+	</StructureSection>
-	[[Category: ~~Kerchner, K.M~~]]	+	[[Category: Large Structures]]
-	[[Category: Sprang~~, S.R~~]]	+	[[Category: Briknarova K]]
		+	[[Category: Kerchner KM]]
		+	[[Category: Mou TC]]
		+	[[Category: Sprang SR]]

OCA at 18:22, 24 June 2020

2020-06-24T18:22:51Z

←Older revision		Revision as of 18:22, 24 June 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6xaz is ON HOLD	+	The entry 6xaz is ON HOLD until Jun 05 2022

	Authors: Mou, T.C., Kerchner, K.M., Sprang, S.R., Briknarova, K.		Authors: Mou, T.C., Kerchner, K.M., Sprang, S.R., Briknarova, K.
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	Description: Structure of the PR domain from human PRDM5		Description: Structure of the PR domain from human PRDM5
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Mou, T.C]]
	[[Category: Briknarova, K]]		[[Category: Briknarova, K]]
	[[Category: Kerchner, K.M]]		[[Category: Kerchner, K.M]]
-	[[Category: Mou, T.C]]
	[[Category: Sprang, S.R]]		[[Category: Sprang, S.R]]

OCA: Protected "6xaz" [edit=sysop:move=sysop]

2020-06-17T08:39:00Z

Protected "6xaz" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:39, 17 June 2020

OCA: New page: '''Unreleased structure''' The entry 6xaz is ON HOLD Authors: Mou, T.C., Kerchner, K.M., Sprang, S.R., Briknarova, K. Description: Structure of the PR domain from human PRDM5 [[Categor...

2020-06-17T08:38:58Z

New page: '''Unreleased structure''' The entry 6xaz is ON HOLD Authors: Mou, T.C., Kerchner, K.M., Sprang, S.R., Briknarova, K. Description: Structure of the PR domain from human PRDM5 [[Categor...

New page

'''Unreleased structure'''

The entry 6xaz is ON HOLD

Authors: Mou, T.C., Kerchner, K.M., Sprang, S.R., Briknarova, K.

Description: Structure of the PR domain from human PRDM5
[[Category: Unreleased Structures]]
[[Category: Briknarova, K]]
[[Category: Kerchner, K.M]]
[[Category: Mou, T.C]]
[[Category: Sprang, S.R]]