6xkk - Revision history

OCA at 14:50, 6 March 2024

2024-03-06T14:50:20Z

←Older revision		Revision as of 14:50, 6 March 2024
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	==Cryo-EM structure of the NLRP1-CARD filament==		==Cryo-EM structure of the NLRP1-CARD filament==
-	<StructureSection load='6xkk' size='340' side='right'caption='[[6xkk]]' scene=''>	+	<StructureSection load='6xkk' size='340' side='right'caption='[[6xkk]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XKK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6XKK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xkk]] is a 44 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XKK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xkk OCA], [~~http~~://pdbe.org/6xkk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6xkk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6xkk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6xkk ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.6Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xkk OCA], [https://pdbe.org/6xkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xkk RCSB], [https://www.ebi.ac.uk/pdbsum/6xkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xkk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/NLRP1_HUMAN NLRP1_HUMAN] Vitiligo-associated autoimmune disease;Vitiligo;Corneal intraepithelial dyskeratosis with palmoplantar hyperkeratosis and laryngeal dyskeratosis. Disease susceptibility is associated with variations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NLRP1_HUMAN NLRP1_HUMAN] As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762).[UniProtKB:A1Z198]<ref>PMID:11113115</ref> <ref>PMID:15212762</ref> <ref>PMID:17349957</ref> <ref>PMID:17418785</ref> <ref>PMID:18511561</ref> <ref>PMID:19651869</ref> <ref>PMID:22665479</ref> <ref>PMID:27662089</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: David L]]		[[Category: David L]]

OCA at 06:55, 25 November 2020

2020-11-25T06:55:39Z

←Older revision		Revision as of 06:55, 25 November 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6xkk ~~is ON HOLD until Paper Publication~~	+	==Cryo-EM structure of the NLRP1-CARD filament==
-		+	<StructureSection load='6xkk' size='340' side='right'caption='[[6xkk]]' scene=''>
-	~~Authors~~: ~~Hollingsworth, L~~.R.~~, David, L~~., ~~Li, Y~~.~~, Sharif, H~~., ~~Fontana, P~~., Fu, T., ~~Wu, H~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XKK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XKK FirstGlance]. <br>
-	~~Description: Cryo-EM structure of the NLRP1-CARD filament~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xkk OCA], [http://pdbe.org/6xkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xkk RCSB], [http://www.ebi.ac.uk/pdbsum/6xkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xkk ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Fontana, P~~]]	+	__TOC__
-	[[Category: ~~Fu, T~~]]	+	</StructureSection>
-	[[Category: ~~Sharif, H~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Li, Y~~]]	+	[[Category: David L]]
-	[[Category: ~~David, L~~]]	+	[[Category: Fontana P]]
-	[[Category: ~~Hollingsworth, L.R~~]]	+	[[Category: Fu T]]
-	[[Category: Wu, H]]	+	[[Category: Hollingsworth LR]]
		+	[[Category: Li Y]]
		+	[[Category: Sharif H]]
		+	[[Category: Wu H]]

OCA at 03:50, 5 August 2020

2020-08-05T03:50:20Z

←Older revision		Revision as of 03:50, 5 August 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6xkk is ON HOLD	+	The entry 6xkk is ON HOLD until Paper Publication

	Authors: Hollingsworth, L.R., David, L., Li, Y., Sharif, H., Fontana, P., Fu, T., Wu, H.		Authors: Hollingsworth, L.R., David, L., Li, Y., Sharif, H., Fontana, P., Fu, T., Wu, H.
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	[[Category: Sharif, H]]		[[Category: Sharif, H]]
	[[Category: Li, Y]]		[[Category: Li, Y]]
-	[[Category: Hollingsworth, L.R]]
	[[Category: David, L]]		[[Category: David, L]]
		+	[[Category: Hollingsworth, L.R]]
	[[Category: Wu, H]]		[[Category: Wu, H]]

OCA: Protected "6xkk" [edit=sysop:move=sysop]

2020-07-08T10:54:42Z

Protected "6xkk" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:54, 8 July 2020

OCA: New page: '''Unreleased structure''' The entry 6xkk is ON HOLD Authors: Hollingsworth, L.R., David, L., Li, Y., Sharif, H., Fontana, P., Fu, T., Wu, H. Description: Cryo-EM structure of the NLRP...

2020-07-08T10:54:41Z

New page: '''Unreleased structure''' The entry 6xkk is ON HOLD Authors: Hollingsworth, L.R., David, L., Li, Y., Sharif, H., Fontana, P., Fu, T., Wu, H. Description: Cryo-EM structure of the NLRP...

New page

'''Unreleased structure'''

The entry 6xkk is ON HOLD

Authors: Hollingsworth, L.R., David, L., Li, Y., Sharif, H., Fontana, P., Fu, T., Wu, H.

Description: Cryo-EM structure of the NLRP1-CARD filament
[[Category: Unreleased Structures]]
[[Category: Fontana, P]]
[[Category: Fu, T]]
[[Category: Sharif, H]]
[[Category: Li, Y]]
[[Category: Hollingsworth, L.R]]
[[Category: David, L]]
[[Category: Wu, H]]