OCA at 10:50, 17 June 2020

2020-06-17T10:50:22Z

←Older revision		Revision as of 10:50, 17 June 2020
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	==Constitutive decay element CDE2 from human 3'UTR==		==Constitutive decay element CDE2 from human 3'UTR==
-	<StructureSection load='6xxa' size='340' side='right'caption='[[6xxa]]' scene=''>	+	<StructureSection load='6xxa' size='340' side='right'caption='[[6xxa]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xxa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxa OCA], [http://pdbe.org/6xxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxa RCSB], [http://www.ebi.ac.uk/pdbsum/6xxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxa ProSAT]</span></td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6xwj\|6xwj]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxa OCA], [http://pdbe.org/6xxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxa RCSB], [http://www.ebi.ac.uk/pdbsum/6xxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxa ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Adenylate/uridylate-rich elements (AREs) are the most common cis-regulatory elements in the 3'-untranslated region (UTR) of mRNAs, where they fine-tune turnover by mediating mRNA decay. They increase plasticity and efficacy of mRNA regulation and are recognized by several ARE-specific RNA-binding proteins (RBPs). Typically, AREs are short linear motifs with a high content of complementary A and U nucleotides and often occur in multiple copies. Although thermodynamically rather unstable, the high AU-content might enable transient secondary structure formation and modify mRNA regulation by RBPs. We have recently suggested that the immunoregulatory RBP Roquin recognizes folded AREs as constitutive decay elements (CDEs), resulting in shape-specific ARE-mediated mRNA degradation. However, the structural evidence for a CDE-like recognition of AREs by Roquin is still lacking. We here present structures of CDE-like folded AREs, both in their free and protein-bound form. Moreover, the AREs in the UCP3 3'-UTR are additionally bound by the canonical ARE-binding protein AUF1 in their linear form, adopting an alternative binding-interface compared to the recognition of their CDE structure by Roquin. Strikingly, our findings thus suggest that AREs can be recognized in multiple ways, allowing control over mRNA regulation by adapting distinct conformational states, thus providing differential accessibility to regulatory RBPs.
		+
		+	Structural basis for the recognition of transiently structured AU-rich elements by Roquin.,Binas O, Tants JN, Peter SA, Janowski R, Davydova E, Braun J, Niessing D, Schwalbe H, Weigand JE, Schlundt A Nucleic Acids Res. 2020 Jun 3. pii: 5850806. doi: 10.1093/nar/gkaa465. PMID:32491174<ref>PMID:32491174</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6xxa" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Binas O]]	+	[[Category: Binas, O]]
-	[[Category: Schwalbe H]]	+	[[Category: Schwalbe, H]]
		+	[[Category: Hairpin roquin binding]]
		+	[[Category: Rna]]

OCA at 07:05, 27 May 2020

2020-05-27T07:05:32Z

←Older revision		Revision as of 07:05, 27 May 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6xxa ~~is ON HOLD~~	+	==Constitutive decay element CDE2 from human 3'UTR==
-		+	<StructureSection load='6xxa' size='340' side='right'caption='[[6xxa]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXA FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxa OCA], [http://pdbe.org/6xxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxa RCSB], [http://www.ebi.ac.uk/pdbsum/6xxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxa ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Binas O]]
		+	[[Category: Schwalbe H]]

OCA: Protected "6xxa" [edit=sysop:move=sysop]

2020-02-05T06:27:40Z

Protected "6xxa" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:27, 5 February 2020

OCA: New page: '''Unreleased structure''' The entry 6xxa is ON HOLD Authors: Description: Category: Unreleased Structures

2020-02-05T06:27:38Z

New page: '''Unreleased structure''' The entry 6xxa is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6xxa is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6xxa - Revision history

OCA at 10:50, 17 June 2020

OCA at 07:05, 27 May 2020

OCA: Protected "6xxa" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6xxa is ON HOLD Authors: Description: Category: Unreleased Structures