6xxv - Revision history

OCA at 13:15, 24 January 2024

2024-01-24T13:15:06Z

←Older revision		Revision as of 13:15, 24 January 2024
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	<StructureSection load='6xxv' size='340' side='right'caption='[[6xxv]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6xxv' size='340' side='right'caption='[[6xxv]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6xxv]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6XXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xxv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XXV FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[6xwi\|6xwi]]~~, [[~~6s3d~~\|~~6s3d~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2011642Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6xxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxv OCA], [~~http~~://pdbe.org/6xxv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6xxv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6xxv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxv OCA], [https://pdbe.org/6xxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xxv RCSB], [https://www.ebi.ac.uk/pdbsum/6xxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxv ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 6xxv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6xxv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Correia~~, B E~~]]	+	[[Category: Correia BE]]
-	[[Category: Pojer, F]]	+	[[Category: Pojer F]]
-	[[Category: Sesterhenn, F]]	+	[[Category: Sesterhenn F]]
-	[[Category: Yang, C]]	+	[[Category: Yang C]]
-	~~[[Category: De novo designed protein]]~~	+
-	~~[[Category: Epitope scaffold]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunogen~~]]	+

OCA at 07:43, 27 May 2020

2020-05-27T07:43:22Z

←Older revision		Revision as of 07:43, 27 May 2020
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxv OCA], [http://pdbe.org/6xxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxv RCSB], [http://www.ebi.ac.uk/pdbsum/6xxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxv OCA], [http://pdbe.org/6xxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxv RCSB], [http://www.ebi.ac.uk/pdbsum/6xxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxv ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	De novo protein design has been successful in expanding the natural protein repertoire. However, most de novo proteins lack biological function, presenting a major methodological challenge. In vaccinology, the induction of precise antibody responses remains a cornerstone for next-generation vaccines. Here, we present a protein design algorithm called TopoBuilder, with which we engineered epitope-focused immunogens displaying complex structural motifs. In both mice and nonhuman primates, cocktails of three de novo-designed immunogens induced robust neutralizing responses against the respiratory syncytial virus. Furthermore, the immunogens refocused preexisting antibody responses toward defined neutralization epitopes. Overall, our design approach opens the possibility of targeting specific epitopes for the development of vaccines and therapeutic antibodies and, more generally, will be applicable to the design of de novo proteins displaying complex functional motifs.
		+
		+	De novo protein design enables the precise induction of RSV-neutralizing antibodies.,Sesterhenn F, Yang C, Bonet J, Cramer JT, Wen X, Wang Y, Chiang CI, Abriata LA, Kucharska I, Castoro G, Vollers SS, Galloux M, Dheilly E, Rosset S, Corthesy P, Georgeon S, Villard M, Richard CA, Descamps D, Delgado T, Oricchio E, Rameix-Welti MA, Mas V, Ervin S, Eleouet JF, Riffault S, Bates JT, Julien JP, Li Y, Jardetzky T, Krey T, Correia BE Science. 2020 May 15;368(6492). pii: 368/6492/eaay5051. doi:, 10.1126/science.aay5051. PMID:32409444<ref>PMID:32409444</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6xxv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:46, 6 May 2020

2020-05-06T06:46:54Z

←Older revision		Revision as of 06:46, 6 May 2020
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	==Crystal Structure of a computationally designed Immunogen S2_1.2 in complex with its elicited antibody C57==		==Crystal Structure of a computationally designed Immunogen S2_1.2 in complex with its elicited antibody C57==
-	<StructureSection load='6xxv' size='340' side='right'caption='[[6xxv]]' scene=''>	+	<StructureSection load='6xxv' size='340' side='right'caption='[[6xxv]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xxv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxv OCA], [http://pdbe.org/6xxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxv RCSB], [http://www.ebi.ac.uk/pdbsum/6xxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxv ProSAT]</span></td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6xwi\|6xwi]], [[6s3d\|6s3d]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxv OCA], [http://pdbe.org/6xxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxv RCSB], [http://www.ebi.ac.uk/pdbsum/6xxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxv ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Correia BE]]	+	[[Category: Correia, B E]]
-	[[Category: Pojer F]]	+	[[Category: Pojer, F]]
-	[[Category: Sesterhenn F]]	+	[[Category: Sesterhenn, F]]
-	[[Category: Yang C]]	+	[[Category: Yang, C]]
		+	[[Category: De novo designed protein]]
		+	[[Category: Epitope scaffold]]
		+	[[Category: Immune system]]
		+	[[Category: Immunogen]]

OCA at 05:49, 22 April 2020

2020-04-22T05:49:57Z

←Older revision		Revision as of 05:49, 22 April 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6xxv is ~~ON HOLD~~	+	==Crystal Structure of a computationally designed Immunogen S2_1.2 in complex with its elicited antibody C57==
-		+	<StructureSection load='6xxv' size='340' side='right'caption='[[6xxv]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXV FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxv OCA], [http://pdbe.org/6xxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxv RCSB], [http://www.ebi.ac.uk/pdbsum/6xxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxv ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Correia BE]]
		+	[[Category: Pojer F]]
		+	[[Category: Sesterhenn F]]
		+	[[Category: Yang C]]

OCA: Protected "6xxv" [edit=sysop:move=sysop]

2020-02-05T06:29:00Z

Protected "6xxv" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:29, 5 February 2020

OCA: New page: '''Unreleased structure''' The entry 6xxv is ON HOLD Authors: Description: Category: Unreleased Structures

2020-02-05T06:28:58Z

New page: '''Unreleased structure''' The entry 6xxv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6xxv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]