6y13 - Revision history

OCA at 12:03, 1 February 2023

2023-02-01T12:03:46Z

←Older revision		Revision as of 12:03, 1 February 2023
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	<StructureSection load='6y13' size='340' side='right'caption='[[6y13]], [[Resolution\|resolution]] 1.11Å' scene=''>		<StructureSection load='6y13' size='340' side='right'caption='[[6y13]], [[Resolution\|resolution]] 1.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6y13]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y13 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6y13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y13 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=~~O65~~:3,~~5-bis(hydroxymethyl)-~~4-~~methyl-benzaldehyde~~'>~~O65~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAB:2,4-DIAMINOBUTYRIC+ACID'>DAB</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=O65:3,5-bis(hydroxymethyl)-4-methyl-benzaldehyde'>O65</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~DAB~~:~~2,4-DIAMINOBUTYRIC~~+~~ACID~~'>~~DAB~~</scene>, <scene name='pdbligand=~~NH2~~:~~AMINO+GROUP~~'>~~NH2~~</scene>, <scene name='pdbligand=~~NLE~~:~~NORLEUCINE~~'>~~NLE~~</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y13 OCA], [https://pdbe.org/6y13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y13 RCSB], [https://www.ebi.ac.uk/pdbsum/6y13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y13 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y13 OCA], [https://pdbe.org/6y13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y13 RCSB], [https://www.ebi.ac.uk/pdbsum/6y13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y13 ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baeriswyl, S]]	+	[[Category: Synthetic construct]]
-	[[Category: Reymond, J L]]	+	[[Category: Baeriswyl S]]
-	[[Category: Stocker, A]]	+	[[Category: Reymond J-L]]
-	~~[[Category: Antibiotic]]~~	+	[[Category: Stocker A]]
-	~~[[Category: Antimicrobial]]~~	+
-	~~[[Category: Bicyclic]]~~	+
-	~~[[Category: Lectin~~]]	+

OCA at 07:07, 2 February 2022

2022-02-02T07:07:48Z

←Older revision		Revision as of 07:07, 2 February 2022
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y13 OCA], [https://pdbe.org/6y13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y13 RCSB], [https://www.ebi.ac.uk/pdbsum/6y13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y13 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y13 OCA], [https://pdbe.org/6y13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y13 RCSB], [https://www.ebi.ac.uk/pdbsum/6y13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y13 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The peptide alpha-helix is right-handed when containing amino acids with l-chirality, and left-handed with d-chirality, however mixed chirality peptides generally do not form alpha-helices unless a helix inducer such as the non-natural residue amino-isobutyric acid is used. Herein we report the first X-ray crystal structures of mixed chirality alpha-helices in short peptides comprising only natural residues as the example of a stapled bicyclic and a linear membrane disruptive amphiphilic antimicrobial peptide (AMP) containing seven l- and four d-residues, as complexes of fucosylated analogs with the bacterial lectin LecB. The mixed chirality alpha-helices are superimposable onto the homochiral alpha-helices and form under similar conditions as shown by CD spectra and MD simulations but non-hemolytic and resistant to proteolysis. The observation of a mixed chirality alpha-helix with only natural residues in the protein environment of LecB suggests a vast unexplored territory of alpha-helical mixed chirality sequences and their possible use for optimizing bioactive alpha-helical peptides.
		+
		+	A mixed chirality alpha-helix in a stapled bicyclic and a linear antimicrobial peptide revealed by X-ray crystallography.,Baeriswyl S, Personne H, Di Bonaventura I, Kohler T, van Delden C, Stocker A, Javor S, Reymond JL RSC Chem Biol. 2021 Aug 20;2(6):1608-1617. doi: 10.1039/d1cb00124h. eCollection, 2021 Dec 2. PMID:34977576<ref>PMID:34977576</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6y13" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:58, 3 March 2021

2021-03-03T14:58:01Z

←Older revision		Revision as of 14:58, 3 March 2021
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-	==Bicyclic stapled peptide ~~bp94~~ at 1.1 Angstrom resolution==	+	==Bicyclic stapled peptide bp70 at 1.1 Angstrom resolution==
-	<StructureSection load='6y13' size='340' side='right'caption='[[6y13]]' scene=''>	+	<StructureSection load='6y13' size='340' side='right'caption='[[6y13]], [[Resolution\|resolution]] 1.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y13 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6y13]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y13 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y13 OCA], [https://pdbe.org/6y13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y13 RCSB], [https://www.ebi.ac.uk/pdbsum/6y13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y13 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O65:3,5-bis(hydroxymethyl)-4-methyl-benzaldehyde'>O65</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAB:2,4-DIAMINOBUTYRIC+ACID'>DAB</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y13 OCA], [https://pdbe.org/6y13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y13 RCSB], [https://www.ebi.ac.uk/pdbsum/6y13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y13 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baeriswyl S]]	+	[[Category: Baeriswyl, S]]
-	[[Category: Reymond J-L]]	+	[[Category: Reymond, J L]]
-	[[Category: Stocker A]]	+	[[Category: Stocker, A]]
		+	[[Category: Antibiotic]]
		+	[[Category: Antimicrobial]]
		+	[[Category: Bicyclic]]
		+	[[Category: Lectin]]

OCA at 09:57, 17 February 2021

2021-02-17T09:57:38Z

←Older revision		Revision as of 09:57, 17 February 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6y13 ~~is ON HOLD until Paper Publication~~	+	==Bicyclic stapled peptide bp94 at 1.1 Angstrom resolution==
-		+	<StructureSection load='6y13' size='340' side='right'caption='[[6y13]]' scene=''>
-	~~Authors~~: ~~Baeriswyl~~, S., ~~Stocker~~, A., ~~Reymond~~, J.-L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y13 FirstGlance]. <br>
-	~~Description: Bicyclic stapled peptide bp94 at 1.1 Angstrom resolution~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y13 OCA], [https://pdbe.org/6y13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y13 RCSB], [https://www.ebi.ac.uk/pdbsum/6y13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y13 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Reymond, J.-L~~]]	+	__TOC__
-	[[Category: ~~Baeriswyl, S~~]]	+	</StructureSection>
-	[[Category: Stocker, A]]	+	[[Category: Large Structures]]
		+	[[Category: Baeriswyl S]]
		+	[[Category: Reymond J-L]]
		+	[[Category: Stocker A]]

OCA at 04:21, 22 April 2020

2020-04-22T04:21:38Z

←Older revision		Revision as of 04:21, 22 April 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6y13 is ON HOLD until ~~sometime in the future~~	+	The entry 6y13 is ON HOLD until Paper Publication

	Authors: Baeriswyl, S., Stocker, A., Reymond, J.-L.		Authors: Baeriswyl, S., Stocker, A., Reymond, J.-L.

OCA at 07:38, 1 April 2020

2020-04-01T07:38:15Z

←Older revision		Revision as of 07:38, 1 April 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6y13 is ON HOLD	+	The entry 6y13 is ON HOLD until sometime in the future

	Authors: Baeriswyl, S., Stocker, A., Reymond, J.-L.		Authors: Baeriswyl, S., Stocker, A., Reymond, J.-L.

OCA: Protected "6y13" [edit=sysop:move=sysop]

2020-02-19T05:26:37Z

Protected "6y13" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:26, 19 February 2020

OCA: New page: '''Unreleased structure''' The entry 6y13 is ON HOLD Authors: Baeriswyl, S., Stocker, A., Reymond, J.-L. Description: Bicyclic stapled peptide bp94 at 1.1 Angstrom resolution [[Categor...

2020-02-19T05:26:36Z

New page: '''Unreleased structure''' The entry 6y13 is ON HOLD Authors: Baeriswyl, S., Stocker, A., Reymond, J.-L. Description: Bicyclic stapled peptide bp94 at 1.1 Angstrom resolution [[Categor...

New page

'''Unreleased structure'''

The entry 6y13 is ON HOLD

Authors: Baeriswyl, S., Stocker, A., Reymond, J.-L.

Description: Bicyclic stapled peptide bp94 at 1.1 Angstrom resolution
[[Category: Unreleased Structures]]
[[Category: Reymond, J.-L]]
[[Category: Baeriswyl, S]]
[[Category: Stocker, A]]