6y6q - Revision history

OCA at 13:20, 24 January 2024

2024-01-24T13:20:35Z

←Older revision		Revision as of 13:20, 24 January 2024
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	<StructureSection load='6y6q' size='340' side='right'caption='[[6y6q]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='6y6q' size='340' side='right'caption='[[6y6q]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6y6q]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Andes_hantavirus~~ Andes ~~hantavirus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y6Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6Y6Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6y6q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Andes_orthohantavirus Andes orthohantavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y6Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA~~</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4~~</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">M, ADT63_77597gpM, ADT63_77598gpM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1980456 Andes hantavirus])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6y6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y6q OCA], [~~http~~://pdbe.org/6y6q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6y6q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6y6q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6y6q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y6q OCA], [https://pdbe.org/6y6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y6q RCSB], [https://www.ebi.ac.uk/pdbsum/6y6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y6q ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GP_ANDV GP_ANDV] Forms homotetramers with glycoprotein C at the surface of the virion (By similarity). Attaches the virion to host cell receptors including integrin ITGAV/ITGB3 (By similarity). This attachment induces virion internalization possibly through clathrin-dependent endocytosis and dynamin-independent macropinocytosis (Probable). Mediates the assembly and budding of infectious virus particles through its interaction with the nucleocapsid protein and the viral genome (By similarity). May dysregulate normal immune and endothelial cell responses through an ITAM motif (By similarity). Translocates to mitochondria, binds to host TUFM and recruits MAP1LC3B (By similarity). These interactions induce mitochondrial autophagy and therefore destruction of host MAVS leading to inhibition of type I interferon (IFN) responses (By similarity). Concomitant breakdown of glycoprotein N is apparently prevented by the nucleoprotein that may inhibit Gn-stimulated autophagosome-lysosome fusion (By similarity). Interacts with the viral genomic RNA (By similarity). Inhibits the host RIG-I/TBK1 pathway by disrupting the formation of TBK1-TRAF3 complexes and downstream signaling responses required for IFN-beta transcription (PubMed:24390324, PubMed:16973572).[UniProtKB:P08668][UniProtKB:P27312]<ref>PMID:16973572</ref> <ref>PMID:24390324</ref> Forms homotetramers with glycoprotein N at the surface of the virion. Attaches the virion to host cell receptors including integrin ITGAV/ITGB3. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity). Class II fusion protein that promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion (PubMed:31180319, PubMed:27414047).[UniProtKB:P08668]<ref>PMID:27414047</ref> <ref>PMID:31180319</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Andes ~~hantavirus~~]]	+	[[Category: Andes orthohantavirus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Guardado-Calvo, P]]	+	[[Category: Guardado-Calvo P]]
-	[[Category: Rey~~, F A~~]]	+	[[Category: Rey FA]]
-	[[Category: Serris, A]]	+	[[Category: Serris A]]
-	~~[[Category: Class-ii fusion protein hantavirus bunyavirus]]~~	+
-	~~[[Category: Postfusion conformation]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 20:52, 28 October 2020

2020-10-28T20:52:21Z

←Older revision		Revision as of 20:52, 28 October 2020
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	==Structure of Andes virus envelope glycoprotein Gc in postfusion conformation==		==Structure of Andes virus envelope glycoprotein Gc in postfusion conformation==
-	<StructureSection load='6y6q' size='340' side='right'caption='[[6y6q]]' scene=''>	+	<StructureSection load='6y6q' size='340' side='right'caption='[[6y6q]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y6Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y6Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6y6q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Andes_hantavirus Andes hantavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y6Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y6Q FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y6q OCA], [http://pdbe.org/6y6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y6q RCSB], [http://www.ebi.ac.uk/pdbsum/6y6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y6q ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M, ADT63_77597gpM, ADT63_77598gpM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1980456 Andes hantavirus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y6q OCA], [http://pdbe.org/6y6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y6q RCSB], [http://www.ebi.ac.uk/pdbsum/6y6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y6q ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hantaviruses are rodent-borne viruses causing serious zoonotic outbreaks worldwide for which no treatment is available. Hantavirus particles are pleomorphic and display a characteristic square surface lattice. The envelope glycoproteins Gn and Gc form heterodimers that further assemble into tetrameric spikes, the lattice building blocks. The glycoproteins, which are the sole targets of neutralizing antibodies, drive virus entry via receptor-mediated endocytosis and endosomal membrane fusion. Here we describe the high-resolution X-ray structures of the heterodimer of Gc and the Gn head and of the homotetrameric Gn base. Docking them into an 11.4-A-resolution cryoelectron tomography map of the hantavirus surface accounted for the complete extramembrane portion of the viral glycoprotein shell and allowed a detailed description of the surface organization of these pleomorphic virions. Our results, which further revealed a built-in mechanism controlling Gc membrane insertion for fusion, pave the way for immunogen design to protect against pathogenic hantaviruses.
		+
		+	The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism.,Serris A, Stass R, Bignon EA, Muena NA, Manuguerra JC, Jangra RK, Li S, Chandran K, Tischler ND, Huiskonen JT, Rey FA, Guardado-Calvo P Cell. 2020 Sep 9. pii: S0092-8674(20)31064-3. doi: 10.1016/j.cell.2020.08.023. PMID:32937107<ref>PMID:32937107</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6y6q" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Andes hantavirus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Guardado-Calvo P]]	+	[[Category: Guardado-Calvo, P]]
-	[[Category: Rey FA]]	+	[[Category: Rey, F A]]
-	[[Category: Serris A]]	+	[[Category: Serris, A]]
		+	[[Category: Class-ii fusion protein hantavirus bunyavirus]]
		+	[[Category: Postfusion conformation]]
		+	[[Category: Viral protein]]

OCA at 05:49, 14 October 2020

2020-10-14T05:49:33Z

←Older revision		Revision as of 05:49, 14 October 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6y6q is ~~ON HOLD until Feb 27 2022~~	+	==Structure of Andes virus envelope glycoprotein Gc in postfusion conformation==
-		+	<StructureSection load='6y6q' size='340' side='right'caption='[[6y6q]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y6Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y6Q FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y6q OCA], [http://pdbe.org/6y6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y6q RCSB], [http://www.ebi.ac.uk/pdbsum/6y6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y6q ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Guardado-Calvo P]]
		+	[[Category: Rey FA]]
		+	[[Category: Serris A]]

OCA at 06:14, 11 March 2020

2020-03-11T06:14:30Z

←Older revision		Revision as of 06:14, 11 March 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6y6q is ON HOLD	+	The entry 6y6q is ON HOLD until Feb 27 2022

	Authors:		Authors:

OCA: Protected "6y6q" [edit=sysop:move=sysop]

2020-03-04T05:47:32Z

Protected "6y6q" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:47, 4 March 2020

OCA: New page: '''Unreleased structure''' The entry 6y6q is ON HOLD Authors: Description: Category: Unreleased Structures

2020-03-04T05:47:31Z

New page: '''Unreleased structure''' The entry 6y6q is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6y6q is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]