6y78 - Revision history

OCA at 13:20, 24 January 2024

2024-01-24T13:20:53Z

←Older revision		Revision as of 13:20, 24 January 2024
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	<StructureSection load='6y78' size='340' side='right'caption='[[6y78]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='6y78' size='340' side='right'caption='[[6y78]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6y78]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y78 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6Y78 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6y78]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y78 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">LGALS3, MAC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6y78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y78 OCA], [~~http~~://pdbe.org/6y78 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6y78 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6y78 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6y78 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y78 OCA], [https://pdbe.org/6y78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y78 RCSB], [https://www.ebi.ac.uk/pdbsum/6y78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y78 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>	+	[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6y78" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6y78" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Galectin 3D structures\|Galectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hakansson, M]]	+	[[Category: Hakansson M]]
-	[[Category: Kovacic, R]]	+	[[Category: Kovacic R]]
-	[[Category: Logan~~, D T~~]]	+	[[Category: Logan DT]]
-	[[Category: Mueller, U]]	+	[[Category: Mueller U]]
-	[[Category: Shilova, A]]	+	[[Category: Shilova A]]
-	[[Category: Welin, M]]	+	[[Category: Welin M]]
-	~~[[Category: Galectin]]~~	+
-	~~[[Category: Silicon nitride membranel]]~~	+
-	~~[[Category: Solid support]]~~	+
-	~~[[Category: Sugar binding protein]]~~	+
-	~~[[Category: Synchrotron serial crystallography~~]]	+

OCA at 10:20, 16 September 2020

2020-09-16T10:20:50Z

←Older revision		Revision as of 10:20, 16 September 2020
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	==Structure of galectin-3C in complex with lactose determined by serial crystallography using a silicon nitride membrane support==		==Structure of galectin-3C in complex with lactose determined by serial crystallography using a silicon nitride membrane support==
-	<StructureSection load='6y78' size='340' side='right'caption='[[6y78]]' scene=''>	+	<StructureSection load='6y78' size='340' side='right'caption='[[6y78]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y78 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y78 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6y78]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y78 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y78 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y78 OCA], [http://pdbe.org/6y78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y78 RCSB], [http://www.ebi.ac.uk/pdbsum/6y78 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y78 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS3, MAC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y78 OCA], [http://pdbe.org/6y78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y78 RCSB], [http://www.ebi.ac.uk/pdbsum/6y78 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y78 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Over the last decade, serial crystallography, a method to collect complete diffraction datasets from a large number of microcrystals delivered and exposed to an X-ray beam in random orientations at room temperature, has been successfully implemented at X-ray free-electron lasers and synchrotron radiation facility beamlines. This development relies on a growing variety of sample presentation methods, including different fixed target supports, injection methods using gas-dynamic virtual-nozzle injectors and high-viscosity extrusion injectors, and acoustic levitation of droplets, each with unique requirements. In comparison with X-ray free-electron lasers, increased beam time availability makes synchrotron facilities very attractive to perform serial synchrotron X-ray crystallography (SSX) experiments. Within this work, the possibilities to perform SSX at BioMAX, the first macromolecular crystallography beamline at MAX IV Laboratory in Lund, Sweden, are described, together with case studies from the SSX user program: an implementation of a high-viscosity extrusion injector to perform room temperature serial crystallography at BioMAX using two solid supports - silicon nitride membranes (Silson, UK) and XtalTool (Jena Bioscience, Germany). Future perspectives for the dedicated serial crystallography beamline MicroMAX at MAX IV Laboratory, which will provide parallel and intense micrometre-sized X-ray beams, are discussed.
		+
		+	Current status and future opportunities for serial crystallography at MAX IV Laboratory.,Shilova A, Lebrette H, Aurelius O, Nan J, Welin M, Kovacic R, Ghosh S, Safari C, Friel RJ, Milas M, Matej Z, Hogbom M, Branden G, Kloos M, Shoeman RL, Doak B, Ursby T, Hakansson M, Logan DT, Mueller U J Synchrotron Radiat. 2020 Sep 1;27(Pt 5):1095-1102. doi:, 10.1107/S1600577520008735. Epub 2020 Aug 21. PMID:32876583<ref>PMID:32876583</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6y78" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hakansson M]]	+	[[Category: Hakansson, M]]
-	[[Category: Kovacic R]]	+	[[Category: Kovacic, R]]
-	[[Category: Logan DT]]	+	[[Category: Logan, D T]]
-	[[Category: Mueller U]]	+	[[Category: Mueller, U]]
-	[[Category: Shilova A]]	+	[[Category: Shilova, A]]
-	[[Category: Welin M]]	+	[[Category: Welin, M]]
		+	[[Category: Galectin]]
		+	[[Category: Silicon nitride membranel]]
		+	[[Category: Solid support]]
		+	[[Category: Sugar binding protein]]
		+	[[Category: Synchrotron serial crystallography]]

OCA at 11:11, 29 July 2020

2020-07-29T11:11:23Z

←Older revision		Revision as of 11:11, 29 July 2020
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-	'''Unreleased structure'''

-	~~The entry 6y78 is ON HOLD~~	+	==Structure of galectin-3C in complex with lactose determined by serial crystallography using a silicon nitride membrane support==
-		+	<StructureSection load='6y78' size='340' side='right'caption='[[6y78]]' scene=''>
-	~~Authors: Hakansson, M., Welin, M., Shilova, A., Kovacic, R., Mueller, U., Logan, D.T.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y78 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y78 FirstGlance]. <br>
-	~~Description:~~ Structure of galectin-3C in complex with lactose determined by serial crystallography using a silicon nitride membrane support	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y78 OCA], [http://pdbe.org/6y78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y78 RCSB], [http://www.ebi.ac.uk/pdbsum/6y78 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y78 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Logan, D.T~~]]	+	__TOC__
-	[[Category: ~~Mueller, U~~]]	+	</StructureSection>
-	[[Category: ~~Shilova, A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Welin, M~~]]	+	[[Category: Hakansson M]]
-	[[Category: ~~Kovacic, R~~]]	+	[[Category: Kovacic R]]
-	[[Category: ~~Hakansson,~~ M]]	+	[[Category: Logan DT]]
		+	[[Category: Mueller U]]
		+	[[Category: Shilova A]]
		+	[[Category: Welin M]]

OCA at 05:04, 10 June 2020

2020-06-10T05:04:50Z

←Older revision		Revision as of 05:04, 10 June 2020
Line 3:		Line 3:
	The entry 6y78 is ON HOLD		The entry 6y78 is ON HOLD

-	Authors: ~~Shilova, A.,~~ Hakansson, M., Welin, M., Kovacic, R., Mueller, U., Logan, D.T.	+	Authors: Hakansson, M., Welin, M., Shilova, A., Kovacic, R., Mueller, U., Logan, D.T.

	Description: Structure of galectin-3C in complex with lactose determined by serial crystallography using a silicon nitride membrane support		Description: Structure of galectin-3C in complex with lactose determined by serial crystallography using a silicon nitride membrane support
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Logan, D.T]]
	[[Category: Mueller, U]]		[[Category: Mueller, U]]
	[[Category: Shilova, A]]		[[Category: Shilova, A]]
	[[Category: Welin, M]]		[[Category: Welin, M]]
-	[[Category: Hakansson, M]]
-	[[Category: Logan, D.T]]
	[[Category: Kovacic, R]]		[[Category: Kovacic, R]]
		+	[[Category: Hakansson, M]]

OCA: Protected "6y78" [edit=sysop:move=sysop]

2020-03-11T06:15:05Z

Protected "6y78" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:15, 11 March 2020

OCA: New page: '''Unreleased structure''' The entry 6y78 is ON HOLD Authors: Shilova, A., Hakansson, M., Welin, M., Kovacic, R., Mueller, U., Logan, D.T. Description: Structure of galectin-3C in comp...

2020-03-11T06:15:04Z

New page: '''Unreleased structure''' The entry 6y78 is ON HOLD Authors: Shilova, A., Hakansson, M., Welin, M., Kovacic, R., Mueller, U., Logan, D.T. Description: Structure of galectin-3C in comp...

New page

'''Unreleased structure'''

The entry 6y78 is ON HOLD

Authors: Shilova, A., Hakansson, M., Welin, M., Kovacic, R., Mueller, U., Logan, D.T.

Description: Structure of galectin-3C in complex with lactose determined by serial crystallography using a silicon nitride membrane support
[[Category: Unreleased Structures]]
[[Category: Mueller, U]]
[[Category: Shilova, A]]
[[Category: Welin, M]]
[[Category: Hakansson, M]]
[[Category: Logan, D.T]]
[[Category: Kovacic, R]]