6yes - Revision history

OCA at 13:25, 24 January 2024

2024-01-24T13:25:20Z

←Older revision		Revision as of 13:25, 24 January 2024
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	<StructureSection load='6yes' size='340' side='right'caption='[[6yes]], [[Resolution\|resolution]] 4.10Å' scene=''>		<StructureSection load='6yes' size='340' side='right'caption='[[6yes]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6yes]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Sulfolobus_islandicus_rudivirus_3~~ Sulfolobus islandicus ~~rudivirus 3~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YES FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yes]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_islandicus_LAL14/1 Sulfolobus islandicus LAL14/1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YES FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.1Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SiL_0609 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=1895333 Sulfolobus islandicus rudivirus 3])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yes OCA], [https://pdbe.org/6yes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yes RCSB], [https://www.ebi.ac.uk/pdbsum/6yes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yes ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yes OCA], [https://pdbe.org/6yes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yes RCSB], [https://www.ebi.ac.uk/pdbsum/6yes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yes ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/M9U4Y8_SULIS M9U4Y8_SULIS]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Sulfolobus islandicus ~~rudivirus 3~~]]	+	[[Category: Sulfolobus islandicus LAL14/1]]
-	[[Category: Brodersen~~, D E~~]]	+	[[Category: Brodersen DE]]
-	[[Category: Manav~~, M C~~]]	+	[[Category: Manav MC]]
-	[[Category: Van~~, L B]]~~	+	[[Category: Van LB]]
-	~~[[Category: Archaea]]~~	+
-	~~[[Category: Ca]]~~	+
-	~~[[Category: Crispr]]~~	+
-	~~[[Category: Dna binding protein~~]]	+

OCA at 03:46, 2 July 2021

2021-07-02T03:46:36Z

←Older revision		Revision as of 03:46, 2 July 2021
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	<StructureSection load='6yes' size='340' side='right'caption='[[6yes]], [[Resolution\|resolution]] 4.10Å' scene=''>		<StructureSection load='6yes' size='340' side='right'caption='[[6yes]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6yes]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sulfolobus_islandicus_rudivirus_3 Sulfolobus islandicus rudivirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YES OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6YES FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yes]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_islandicus_rudivirus_3 Sulfolobus islandicus rudivirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YES FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6yes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yes OCA], [~~http~~://pdbe.org/6yes PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6yes RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6yes PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6yes ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SiL_0609 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1895333 Sulfolobus islandicus rudivirus 3])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yes OCA], [https://pdbe.org/6yes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yes RCSB], [https://www.ebi.ac.uk/pdbsum/6yes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yes ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:51, 9 December 2020

2020-12-09T06:51:19Z

←Older revision		Revision as of 06:51, 9 December 2020
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yes OCA], [http://pdbe.org/6yes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yes RCSB], [http://www.ebi.ac.uk/pdbsum/6yes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yes ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yes OCA], [http://pdbe.org/6yes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yes RCSB], [http://www.ebi.ac.uk/pdbsum/6yes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yes ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A hallmark of type I CRISPR-Cas systems is the presence of Cas3, which contains both the nuclease and helicase activities required for DNA cleavage during interference. In subtype I-D systems, however, the histidine-aspartate (HD) nuclease domain is encoded as part of a Cas10-like large effector complex subunit and the helicase activity in a separate Cas3' subunit, but the functional and mechanistic consequences of this organisation are not currently understood. Here we show that the Sulfolobus islandicus type I-D Cas10d large subunit exhibits an unusual domain architecture consisting of a Cas3-like HD nuclease domain fused to a degenerate polymerase fold and a C-terminal domain structurally similar to Cas11. Crystal structures of Cas10d both in isolation and bound to S. islandicus rod-shaped virus 3 AcrID1 reveal that the anti-CRISPR protein sequesters the large subunit in a non-functional state unable to form a cleavage-competent effector complex. The architecture of Cas10d suggests that the type I-D effector complex is similar to those found in type III CRISPR-Cas systems and that this feature is specifically exploited by phages for anti-CRISPR defence.
		+
		+	Structural basis for inhibition of an archaeal CRISPR-Cas type I-D large subunit by an anti-CRISPR protein.,Manav MC, Van LB, Lin J, Fuglsang A, Peng X, Brodersen DE Nat Commun. 2020 Nov 25;11(1):5993. doi: 10.1038/s41467-020-19847-x. PMID:33239638<ref>PMID:33239638</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6yes" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:15, 2 December 2020

2020-12-02T08:15:23Z

←Older revision		Revision as of 08:15, 2 December 2020
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	==Crystal structure of type I-D CRISPR-Cas nuclease Cas10d==		==Crystal structure of type I-D CRISPR-Cas nuclease Cas10d==
-	<StructureSection load='6yes' size='340' side='right'caption='[[6yes]]' scene=''>	+	<StructureSection load='6yes' size='340' side='right'caption='[[6yes]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YES OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YES FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yes]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_islandicus_rudivirus_3 Sulfolobus islandicus rudivirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YES OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YES FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yes OCA], [http://pdbe.org/6yes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yes RCSB], [http://www.ebi.ac.uk/pdbsum/6yes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yes ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yes OCA], [http://pdbe.org/6yes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yes RCSB], [http://www.ebi.ac.uk/pdbsum/6yes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yes ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brodersen DE]]	+	[[Category: Sulfolobus islandicus rudivirus 3]]
-	[[Category: Manav MC]]	+	[[Category: Brodersen, D E]]
-	[[Category: Van LB]]	+	[[Category: Manav, M C]]
		+	[[Category: Van, L B]]
		+	[[Category: Archaea]]
		+	[[Category: Ca]]
		+	[[Category: Crispr]]
		+	[[Category: Dna binding protein]]

OCA at 20:34, 28 October 2020

2020-10-28T20:34:58Z

←Older revision		Revision as of 20:34, 28 October 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6yes is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of type I-D CRISPR-Cas nuclease Cas10d==
-		+	<StructureSection load='6yes' size='340' side='right'caption='[[6yes]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YES OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YES FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yes OCA], [http://pdbe.org/6yes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yes RCSB], [http://www.ebi.ac.uk/pdbsum/6yes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yes ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Brodersen DE]]
		+	[[Category: Manav MC]]
		+	[[Category: Van LB]]

OCA at 07:20, 22 July 2020

2020-07-22T07:20:10Z

←Older revision		Revision as of 07:20, 22 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6yes is ON HOLD	+	The entry 6yes is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 04:25, 20 May 2020

2020-05-20T04:25:35Z

←Older revision		Revision as of 04:25, 20 May 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6yes is ON HOLD ~~until Paper Publication~~	+	The entry 6yes is ON HOLD

	Authors:		Authors:

OCA at 05:41, 8 April 2020

2020-04-08T05:41:50Z

←Older revision		Revision as of 05:41, 8 April 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6yes is ON HOLD	+	The entry 6yes is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6yes" [edit=sysop:move=sysop]

2020-04-01T07:45:48Z

Protected "6yes" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:45, 1 April 2020

OCA: New page: '''Unreleased structure''' The entry 6yes is ON HOLD Authors: Description: Category: Unreleased Structures

2020-04-01T07:45:46Z

New page: '''Unreleased structure''' The entry 6yes is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6yes is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]