6ypo - Revision history

OCA at 13:32, 24 January 2024

2024-01-24T13:32:46Z

←Older revision		Revision as of 13:32, 24 January 2024
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	==Arabidopsis aspartate transcarbamoylase bound to UMP==		==Arabidopsis aspartate transcarbamoylase bound to UMP==
-	<StructureSection load='6ypo' size='340' side='right'caption='[[6ypo]]' scene=''>	+	<StructureSection load='6ypo' size='340' side='right'caption='[[6ypo]], [[Resolution\|resolution]] 1.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YPO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ypo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YPO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ypo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ypo OCA], [https://pdbe.org/6ypo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ypo RCSB], [https://www.ebi.ac.uk/pdbsum/6ypo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ypo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.67Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ypo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ypo OCA], [https://pdbe.org/6ypo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ypo RCSB], [https://www.ebi.ac.uk/pdbsum/6ypo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ypo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PYRB_ARATH PYRB_ARATH]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aspartate transcarbamoylase (ATC), an essential enzyme for de novo pyrimidine biosynthesis, is uniquely regulated in plants by feedback inhibition of uridine 5-monophosphate (UMP). Despite its importance in plant growth, the structure of this UMP-controlled ATC and the regulatory mechanism remain unknown. Here, we report the crystal structures of Arabidopsis ATC trimer free and bound to UMP, complexed to a transition-state analog or bearing a mutation that turns the enzyme insensitive to UMP. We found that UMP binds and blocks the ATC active site, directly competing with the binding of the substrates. We also prove that UMP recognition relies on a loop exclusively conserved in plants that is also responsible for the sequential firing of the active sites. In this work, we describe unique regulatory and catalytic properties of plant ATCs that could be exploited to modulate de novo pyrimidine synthesis and plant growth.
		+
		+	Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase.,Bellin L, Del Cano-Ochoa F, Velazquez-Campoy A, Mohlmann T, Ramon-Maiques S Nat Commun. 2021 Feb 11;12(1):947. doi: 10.1038/s41467-021-21165-9. PMID:33574254<ref>PMID:33574254</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ypo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aspartate carbamoyltransferase 3D structures\|Aspartate carbamoyltransferase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bellin L]]		[[Category: Bellin L]]

OCA at 14:42, 3 March 2021

2021-03-03T14:42:26Z

←Older revision		Revision as of 14:42, 3 March 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6ypo is ~~ON HOLD until Paper Publication~~	+	==Arabidopsis aspartate transcarbamoylase bound to UMP==
-		+	<StructureSection load='6ypo' size='340' side='right'caption='[[6ypo]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YPO FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ypo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ypo OCA], [https://pdbe.org/6ypo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ypo RCSB], [https://www.ebi.ac.uk/pdbsum/6ypo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ypo ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bellin L]]
		+	[[Category: Del Cano Ochoa F]]
		+	[[Category: Mohlmann T]]
		+	[[Category: Ramon Maiques S]]

OCA at 04:26, 20 May 2020

2020-05-20T04:26:21Z

←Older revision		Revision as of 04:26, 20 May 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ypo is ON HOLD	+	The entry 6ypo is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 05:24, 29 April 2020

2020-04-29T05:24:07Z

←Older revision		Revision as of 05:24, 29 April 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ypo is ON HOLD ~~until sometime in the future~~	+	The entry 6ypo is ON HOLD

	Authors:		Authors:

OCA: Protected "6ypo" [edit=sysop:move=sysop]

2020-04-22T04:31:48Z

Protected "6ypo" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:31, 22 April 2020

OCA: New page: '''Unreleased structure''' The entry 6ypo is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

2020-04-22T04:31:46Z

New page: '''Unreleased structure''' The entry 6ypo is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ypo is ON HOLD until sometime in the future

Authors:

Description:
[[Category: Unreleased Structures]]