6yrg - Revision history

OCA at 10:21, 22 May 2024

2024-05-22T10:21:35Z

←Older revision		Revision as of 10:21, 22 May 2024
Line 3:		Line 3:
	<StructureSection load='6yrg' size='340' side='right'caption='[[6yrg]], [[Resolution\|resolution]] 7.00Å' scene=''>		<StructureSection load='6yrg' size='340' side='right'caption='[[6yrg]], [[Resolution\|resolution]] 7.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6yrg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_cereus_var._thuringiensis"_smith_et_al._1952 "bacillus cereus var.~~ thuringiensis~~" smith et al. 1952~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YRG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yrg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YRG FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>vip3Bc1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1428~~ "~~Bacillus cereus var. thuringiensis~~" ~~Smith et al. 1952~~])</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 7Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yrg OCA], [https://pdbe.org/6yrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yrg RCSB], [https://www.ebi.ac.uk/pdbsum/6yrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yrg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yrg OCA], [https://pdbe.org/6yrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yrg RCSB], [https://www.ebi.ac.uk/pdbsum/6yrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yrg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A290WPI2_BACTU A0A290WPI2_BACTU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~cereus var.~~ thuringiensis ~~smith et al. 1952~~]]	+	[[Category: Bacillus thuringiensis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Byrne~~, M J~~]]	+	[[Category: Byrne MJ]]
-	[[Category: Iadanza~~, M I~~]]	+	[[Category: Iadanza MI]]
-	[[Category: Thompson~~, R F]]~~	+	[[Category: Thompson RF]]
-	~~[[Category: Bt toxin]]~~	+
-	~~[[Category: Toxin]]~~	+
-	~~[[Category: Vip3~~]]	+

OCA at 09:25, 26 May 2021

2021-05-26T09:25:48Z

←Older revision		Revision as of 09:25, 26 May 2021
Line 1:		Line 1:

	==Vip3Bc1 tetramer in processed, activated state==		==Vip3Bc1 tetramer in processed, activated state==
-	<StructureSection load='6yrg' size='340' side='right'caption='[[6yrg]]' scene=''>	+	<StructureSection load='6yrg' size='340' side='right'caption='[[6yrg]], [[Resolution\|resolution]] 7.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YRG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yrg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_cereus_var._thuringiensis"_smith_et_al._1952 "bacillus cereus var. thuringiensis" smith et al. 1952]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YRG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yrg OCA], [https://pdbe.org/6yrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yrg RCSB], [https://www.ebi.ac.uk/pdbsum/6yrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yrg ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">vip3Bc1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1428 "Bacillus cereus var. thuringiensis" Smith et al. 1952])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yrg OCA], [https://pdbe.org/6yrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yrg RCSB], [https://www.ebi.ac.uk/pdbsum/6yrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yrg ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Insect pests are a major cause of crop losses worldwide, with an estimated economic cost of $470 billion annually. Biotechnological tools have been introduced to control such insects without the need for chemical pesticides; for instance, the development of transgenic plants harbouring genes encoding insecticidal proteins. The Vip3 (vegetative insecticidal protein 3) family proteins from Bacillus thuringiensis convey toxicity to species within the Lepidoptera, and have wide potential applications in commercial agriculture. Vip3 proteins are proposed to exert their insecticidal activity through pore formation, though to date there is no mechanistic description of how this occurs on the membrane. Here we present cryo-EM structures of a Vip3 family toxin in both inactive and activated forms in conjunction with structural and functional data on toxin-membrane interactions. Together these data demonstrate that activated Vip3Bc1 complex is able to insert into membranes in a highly efficient manner, indicating that receptor binding is the likely driver of Vip3 specificity.
		+
		+	Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane.,Byrne MJ, Iadanza MG, Perez MA, Maskell DP, George RM, Hesketh EL, Beales PA, Zack MD, Berry C, Thompson RF Nat Commun. 2021 May 14;12(1):2791. doi: 10.1038/s41467-021-23146-4. PMID:33990582<ref>PMID:33990582</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6yrg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus cereus var. thuringiensis smith et al. 1952]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Byrne MJ]]	+	[[Category: Byrne, M J]]
-	[[Category: Iadanza MI]]	+	[[Category: Iadanza, M I]]
-	[[Category: Thompson RF]]	+	[[Category: Thompson, R F]]
		+	[[Category: Bt toxin]]
		+	[[Category: Toxin]]
		+	[[Category: Vip3]]

OCA at 06:43, 17 March 2021

2021-03-17T06:43:23Z

←Older revision		Revision as of 06:43, 17 March 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6yrg is ~~ON HOLD until Paper Publication~~	+	==Vip3Bc1 tetramer in processed, activated state==
-		+	<StructureSection load='6yrg' size='340' side='right'caption='[[6yrg]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YRG FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yrg OCA], [https://pdbe.org/6yrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yrg RCSB], [https://www.ebi.ac.uk/pdbsum/6yrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yrg ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Byrne MJ]]
		+	[[Category: Iadanza MI]]
		+	[[Category: Thompson RF]]

OCA at 14:23, 10 March 2021

2021-03-10T14:23:19Z

←Older revision		Revision as of 14:23, 10 March 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6yrg is ON HOLD	+	The entry 6yrg is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6yrg" [edit=sysop:move=sysop]

2020-04-29T05:27:05Z

Protected "6yrg" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:27, 29 April 2020

OCA: New page: '''Unreleased structure''' The entry 6yrg is ON HOLD Authors: Description: Category: Unreleased Structures

2020-04-29T05:27:04Z

New page: '''Unreleased structure''' The entry 6yrg is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6yrg is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]