6z8u - Revision history

OCA at 13:43, 24 January 2024

2024-01-24T13:43:55Z

←Older revision		Revision as of 13:43, 24 January 2024
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	<StructureSection load='6z8u' size='340' side='right'caption='[[6z8u]], [[Resolution\|resolution]] 2.61Å' scene=''>		<StructureSection load='6z8u' size='340' side='right'caption='[[6z8u]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6z8u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z8U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6z8u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z8U FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AG:SILVER+ION'>AG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.61Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[6fok\|6fok]], [[6fom\|6fom]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG:SILVER+ION'>AG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">oprC, PA3790 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z8u OCA], [https://pdbe.org/6z8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z8u RCSB], [https://www.ebi.ac.uk/pdbsum/6z8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z8u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z8u OCA], [https://pdbe.org/6z8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z8u RCSB], [https://www.ebi.ac.uk/pdbsum/6z8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z8u ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G3XD89_PSEAE G3XD89_PSEAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseae]]~~	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	~~[[Category: Berg, B van den~~]]	+	[[Category: Bhamidimarri SP]]
-	[[Category: Bhamidimarri~~, S P~~]]	+	[[Category: Van den Berg B]]
-	[[Category: ~~Copper transporter]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Oprc]]~~	+
-	~~[[Category: Pseudomonas aeruginosa]]~~	+
-	~~[[Category: Tbdt~~]]	+

OCA at 06:25, 1 December 2021

2021-12-01T06:25:44Z

←Older revision		Revision as of 06:25, 1 December 2021
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	==Copper transporter OprC==		==Copper transporter OprC==
-	<StructureSection load='6z8u' size='340' side='right'caption='[[6z8u]]' scene=''>	+	<StructureSection load='6z8u' size='340' side='right'caption='[[6z8u]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z8U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6z8u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z8U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z8u OCA], [https://pdbe.org/6z8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z8u RCSB], [https://www.ebi.ac.uk/pdbsum/6z8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z8u ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG:SILVER+ION'>AG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6fok\|6fok]], [[6fom\|6fom]]</div></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">oprC, PA3790 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z8u OCA], [https://pdbe.org/6z8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z8u RCSB], [https://www.ebi.ac.uk/pdbsum/6z8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z8u ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Copper, while toxic in excess, is an essential micronutrient in all kingdoms of life due to its essential role in the structure and function of many proteins. Proteins mediating ionic copper import have been characterised in detail for eukaryotes, but much less so for prokaryotes. In particular, it is still unclear whether and how gram-negative bacteria acquire ionic copper. Here, we show that Pseudomonas aeruginosa OprC is an outer membrane, TonB-dependent transporter that is conserved in many Proteobacteria and which mediates acquisition of both reduced and oxidised ionic copper via an unprecedented CxxxM-HxM metal binding site. Crystal structures of wild-type and mutant OprC variants with silver and copper suggest that acquisition of Cu(I) occurs via a surface-exposed "methionine track" leading towards the principal metal binding site. Together with whole-cell copper quantitation and quantitative proteomics in a murine lung infection model, our data identify OprC as an abundant component of bacterial copper biology that may enable copper acquisition under a wide range of conditions.
		+
		+	Acquisition of ionic copper by the bacterial outer membrane protein OprC through a novel binding site.,Bhamidimarri SP, Young TR, Shanmugam M, Soderholm S, Basle A, Bumann D, van den Berg B PLoS Biol. 2021 Nov 11;19(11):e3001446. doi: 10.1371/journal.pbio.3001446., eCollection 2021 Nov. PMID:34762655<ref>PMID:34762655</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6z8u" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Bhamidimarri SP~~]]	+	[[Category: Pseae]]
-	[[Category: ~~Van den~~ Berg B]]	+	[[Category: Berg, B van den]]
		+	[[Category: Bhamidimarri, S P]]
		+	[[Category: Copper transporter]]
		+	[[Category: Membrane protein]]
		+	[[Category: Oprc]]
		+	[[Category: Pseudomonas aeruginosa]]
		+	[[Category: Tbdt]]

OCA at 12:10, 9 June 2021

2021-06-09T12:10:20Z

←Older revision		Revision as of 12:10, 9 June 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6z8u ~~is ON HOLD until Paper Publication~~	+	==Copper transporter OprC==
-		+	<StructureSection load='6z8u' size='340' side='right'caption='[[6z8u]]' scene=''>
-	~~Authors~~: ~~Bhamidimarri~~, S.P., ~~van den Berg~~, B.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z8U FirstGlance]. <br>
-	~~Description: Copper transporter OprC~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z8u OCA], [https://pdbe.org/6z8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z8u RCSB], [https://www.ebi.ac.uk/pdbsum/6z8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z8u ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Van Den Berg, B~~]]	+	__TOC__
-	[[Category: ~~Bhamidimarri, S.P~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bhamidimarri SP]]
		+	[[Category: Van den Berg B]]

OCA at 07:49, 22 July 2020

2020-07-22T07:49:03Z

←Older revision		Revision as of 07:49, 22 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6z8u is ON HOLD	+	The entry 6z8u is ON HOLD until Paper Publication

	Authors: Bhamidimarri, S.P., van den Berg, B.		Authors: Bhamidimarri, S.P., van den Berg, B.

OCA: Protected "6z8u" [edit=sysop:move=sysop]

2020-06-10T05:11:09Z

Protected "6z8u" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:11, 10 June 2020

OCA: New page: '''Unreleased structure''' The entry 6z8u is ON HOLD Authors: Bhamidimarri, S.P., van den Berg, B. Description: Copper transporter OprC Category: Unreleased Structures [[Category: ...

2020-06-10T05:11:08Z

New page: '''Unreleased structure''' The entry 6z8u is ON HOLD Authors: Bhamidimarri, S.P., van den Berg, B. Description: Copper transporter OprC Category: Unreleased Structures [[Category: ...

New page

'''Unreleased structure'''

The entry 6z8u is ON HOLD

Authors: Bhamidimarri, S.P., van den Berg, B.

Description: Copper transporter OprC
[[Category: Unreleased Structures]]
[[Category: Van Den Berg, B]]
[[Category: Bhamidimarri, S.P]]