6zc6 - Revision history

OCA at 13:46, 24 January 2024

2024-01-24T13:46:24Z

←Older revision		Revision as of 13:46, 24 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6zc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZC6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6zc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZC6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QEN:5-bromanyl-2-(naphthalen-2-ylsulfonylamino)benzoic+acid'>QEN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.58Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QEN:5-bromanyl-2-(naphthalen-2-ylsulfonylamino)benzoic+acid'>QEN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zc6 OCA], [https://pdbe.org/6zc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zc6 RCSB], [https://www.ebi.ac.uk/pdbsum/6zc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zc6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zc6 OCA], [https://pdbe.org/6zc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zc6 RCSB], [https://www.ebi.ac.uk/pdbsum/6zc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zc6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN]] Autosomal dominant Robinow syndrome. The disease is caused by variants affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN] Autosomal dominant Robinow syndrome. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN]] Involved in the signal transduction pathway mediated by multiple Wnt genes.[UniProtKB:Q61062]	+	[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN] Involved in the signal transduction pathway mediated by multiple Wnt genes.[UniProtKB:Q61062]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:20, 8 September 2022

2022-09-08T05:20:45Z

←Older revision		Revision as of 05:20, 8 September 2022
Line 3:		Line 3:
	<StructureSection load='6zc6' size='340' side='right'caption='[[6zc6]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='6zc6' size='340' side='right'caption='[[6zc6]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6zc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZC6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZC6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QEN:5-bromanyl-2-(naphthalen-2-ylsulfonylamino)benzoic+acid'>QEN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QEN:5-bromanyl-2-(naphthalen-2-ylsulfonylamino)benzoic+acid'>QEN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DVL3, KIAA0208 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zc6 OCA], [https://pdbe.org/6zc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zc6 RCSB], [https://www.ebi.ac.uk/pdbsum/6zc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zc6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zc6 OCA], [https://pdbe.org/6zc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zc6 RCSB], [https://www.ebi.ac.uk/pdbsum/6zc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zc6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN]] Autosomal dominant Robinow syndrome. The disease is caused by variants affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN]] Autosomal dominant Robinow syndrome. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN]] Involved in the signal transduction pathway mediated by multiple Wnt genes.[UniProtKB:Q61062]	+	[[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN]] Involved in the signal transduction pathway mediated by multiple Wnt genes.[UniProtKB:Q61062]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Heinemann, U]]	+	[[Category: Heinemann U]]
-	[[Category: Oschkinat, H]]	+	[[Category: Oschkinat H]]
-	[[Category: Roske, Y]]	+	[[Category: Roske Y]]
-	~~[[Category: Dvl]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Pdz]]~~	+
-	~~[[Category: Peptide binding protein]]~~	+
-	~~[[Category: Signalling]]~~	+
-	~~[[Category: Wnt~~]]	+

OCA at 07:02, 20 July 2022

2022-07-20T07:02:58Z

←Older revision		Revision as of 07:02, 20 July 2022
Line 1:		Line 1:

	==Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling==		==Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling==
-	<StructureSection load='6zc6' size='340' side='right'caption='[[6zc6]]' scene=''>	+	<StructureSection load='6zc6' size='340' side='right'caption='[[6zc6]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZC6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZC6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zc6 OCA], [https://pdbe.org/6zc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zc6 RCSB], [https://www.ebi.ac.uk/pdbsum/6zc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zc6 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QEN:5-bromanyl-2-(naphthalen-2-ylsulfonylamino)benzoic+acid'>QEN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DVL3, KIAA0208 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zc6 OCA], [https://pdbe.org/6zc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zc6 RCSB], [https://www.ebi.ac.uk/pdbsum/6zc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zc6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN]] Autosomal dominant Robinow syndrome. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN]] Involved in the signal transduction pathway mediated by multiple Wnt genes.[UniProtKB:Q61062]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Heinemann U]]	+	[[Category: Heinemann, U]]
-	[[Category: Oschkinat H]]	+	[[Category: Oschkinat, H]]
-	[[Category: Roske Y]]	+	[[Category: Roske, Y]]
		+	[[Category: Dvl]]
		+	[[Category: Inhibitor]]
		+	[[Category: Pdz]]
		+	[[Category: Peptide binding protein]]
		+	[[Category: Signalling]]
		+	[[Category: Wnt]]

OCA at 07:28, 25 June 2021

2021-06-25T07:28:45Z

←Older revision		Revision as of 07:28, 25 June 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6zc6 is ON HOLD until Paper Publication~~	+	==Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling==
-		+	<StructureSection load='6zc6' size='340' side='right'caption='[[6zc6]]' scene=''>
-	~~Authors: Roske, Y., Heinemann, U., Oschkinat, H.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZC6 FirstGlance]. <br>
-	~~Description:~~ Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zc6 OCA], [https://pdbe.org/6zc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zc6 RCSB], [https://www.ebi.ac.uk/pdbsum/6zc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zc6 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Oschkinat~~, H]]	+	__TOC__
-	[[Category: Heinemann, U]]	+	</StructureSection>
-	[[Category: Roske, Y]]	+	[[Category: Large Structures]]
		+	[[Category: Heinemann U]]
		+	[[Category: Oschkinat H]]
		+	[[Category: Roske Y]]

OCA at 07:52, 22 July 2020

2020-07-22T07:52:56Z

←Older revision		Revision as of 07:52, 22 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6zc6 is ON HOLD	+	The entry 6zc6 is ON HOLD until Paper Publication

	Authors: Roske, Y., Heinemann, U., Oschkinat, H.		Authors: Roske, Y., Heinemann, U., Oschkinat, H.

OCA: Protected "6zc6" [edit=sysop:move=sysop]

2020-06-17T08:56:12Z

Protected "6zc6" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:56, 17 June 2020

OCA: New page: '''Unreleased structure''' The entry 6zc6 is ON HOLD Authors: Roske, Y., Heinemann, U., Oschkinat, H. Description: Small-molecule inhibitors of the PDZ domain of Dishevelled proteins i...

2020-06-17T08:56:11Z

New page: '''Unreleased structure''' The entry 6zc6 is ON HOLD Authors: Roske, Y., Heinemann, U., Oschkinat, H. Description: Small-molecule inhibitors of the PDZ domain of Dishevelled proteins i...

New page

'''Unreleased structure'''

The entry 6zc6 is ON HOLD

Authors: Roske, Y., Heinemann, U., Oschkinat, H.

Description: Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
[[Category: Unreleased Structures]]
[[Category: Oschkinat, H]]
[[Category: Heinemann, U]]
[[Category: Roske, Y]]