6zlz - Revision history

OCA at 11:54, 1 February 2024

2024-02-01T11:54:22Z

←Older revision		Revision as of 11:54, 1 February 2024
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	<StructureSection load='6zlz' size='340' side='right'caption='[[6zlz]], [[Resolution\|resolution]] 3.52Å' scene=''>		<StructureSection load='6zlz' size='340' side='right'caption='[[6zlz]], [[Resolution\|resolution]] 3.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6zlz]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Mcpyv_isolate_r17b Mcpyv isolate r17b~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZLZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ZLZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zlz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Merkel_cell_polyomavirus Merkel cell polyomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZLZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.52Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~VP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=493803 MCPyV isolate R17b])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6zlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zlz OCA], [~~http~~://pdbe.org/6zlz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6zlz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6zlz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6zlz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zlz OCA], [https://pdbe.org/6zlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zlz RCSB], [https://www.ebi.ac.uk/pdbsum/6zlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zlz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B0G0W3_9POLY B0G0W3_9POLY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6zlz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6zlz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mcpyv isolate r17b~~]]	+	[[Category: Merkel cell polyomavirus]]
-	[[Category: Bayer~~, N J~~]]	+	[[Category: Bayer NJ]]
-	[[Category: Blaum~~, B S~~]]	+	[[Category: Blaum BS]]
-	[[Category: Stehle, T]]	+	[[Category: Stehle T]]
-	~~[[Category: Capsid]]~~	+
-	~~[[Category: Jelly roll fold]]~~	+
-	~~[[Category: Merkel cell carcinoma]]~~	+
-	~~[[Category: Polyomavirus]]~~	+
-	~~[[Category: Virus like particle~~]]	+

OCA at 06:42, 7 October 2020

2020-10-07T06:42:43Z

←Older revision		Revision as of 06:42, 7 October 2020
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	==Crystal Structure of Merkel Cell Polyomavirus Virus-like Particle==		==Crystal Structure of Merkel Cell Polyomavirus Virus-like Particle==
-	<StructureSection load='6zlz' size='340' side='right'caption='[[6zlz]]' scene=''>	+	<StructureSection load='6zlz' size='340' side='right'caption='[[6zlz]], [[Resolution\|resolution]] 3.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZLZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZLZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zlz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mcpyv_isolate_r17b Mcpyv isolate r17b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZLZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZLZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zlz OCA], [http://pdbe.org/6zlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zlz RCSB], [http://www.ebi.ac.uk/pdbsum/6zlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zlz ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=493803 MCPyV isolate R17b])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zlz OCA], [http://pdbe.org/6zlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zlz RCSB], [http://www.ebi.ac.uk/pdbsum/6zlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zlz ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Merkel cell polyomavirus (MCPyV) is a human double-stranded DNA tumor virus. MCPyV cell entry is unique among the polyomavirus family as it requires the engagement of two types of glycans, sialylated oligosaccharides and sulfated glycosaminoglycans (GAGs). Here, we present crystallographic and cryo-electron microscopic structures of the icosahedral MCPyV capsid and analysis of its glycan interactions via NMR spectroscopy. While sialic acid binding is specific for alpha2-3-linked sialic acid and mediated by the exposed apical loops of the major capsid protein VP1, a broad range of GAG oligosaccharides bind to recessed regions between VP1 capsomers. Individual VP1 capsomers are tethered to one another by an extensive disulfide network that differs in architecture from previously-described interactions for other PyVs. An unusual C-terminal extension in MCPyV VP1 projects from the recessed capsid regions. Mutagenesis experiments show that this extension is dispensable for receptor interaction.IMPORTANCEThe MCPyV genome was found to be clonally integrated in 80% of Merkel cell carcinoma (MCC), a rare but aggressive form of human skin cancer, strongly suggesting that this virus is tumorigenic. In the metastasizing state the course of disease is often fatal, especially in immunocompromised individuals, as reflected by the high mortality rate of 33-46% and low 5-year survival rate (< 45%). The high seroprevalence of about 60% makes MCPyV a serious healthcare burden and illustrates the need for targeted treatments. In this study we present the first high-resolution structural data of this human tumor virus and demonstrate that the full capsid is required for the essential interaction with its GAG receptor(s). Together this data can be used as a basis for future strategies in drug development.
		+
		+	Structure of Merkel cell polyomavirus capsid and interaction with its glycosaminoglycan attachment receptor.,Bayer NJ, Januliene D, Zocher G, Stehle T, Moeller A, Blaum BS J Virol. 2020 Jul 22. pii: JVI.01664-19. doi: 10.1128/JVI.01664-19. PMID:32699083<ref>PMID:32699083</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6zlz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bayer NJ]]	+	[[Category: Mcpyv isolate r17b]]
-	[[Category: Blaum BS]]	+	[[Category: Bayer, N J]]
-	[[Category: Stehle T]]	+	[[Category: Blaum, B S]]
		+	[[Category: Stehle, T]]
		+	[[Category: Capsid]]
		+	[[Category: Jelly roll fold]]
		+	[[Category: Merkel cell carcinoma]]
		+	[[Category: Polyomavirus]]
		+	[[Category: Virus like particle]]

OCA at 05:36, 5 August 2020

2020-08-05T05:36:43Z

←Older revision		Revision as of 05:36, 5 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6zlz is ~~ON HOLD~~	+	==Crystal Structure of Merkel Cell Polyomavirus Virus-like Particle==
-		+	<StructureSection load='6zlz' size='340' side='right'caption='[[6zlz]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZLZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZLZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zlz OCA], [http://pdbe.org/6zlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zlz RCSB], [http://www.ebi.ac.uk/pdbsum/6zlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zlz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bayer NJ]]
		+	[[Category: Blaum BS]]
		+	[[Category: Stehle T]]

OCA: Protected "6zlz" [edit=sysop:move=sysop]

2020-07-08T11:19:20Z

Protected "6zlz" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:19, 8 July 2020

OCA: New page: '''Unreleased structure''' The entry 6zlz is ON HOLD Authors: Description: Category: Unreleased Structures

2020-07-08T11:19:18Z

New page: '''Unreleased structure''' The entry 6zlz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6zlz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]