OCA at 11:54, 1 February 2024

2024-02-01T11:54:51Z

←Older revision		Revision as of 11:54, 1 February 2024
Line 1:		Line 1:

-	====	+	==Plasmodium facliparum glideosome trimeric sub-complex==
-	<StructureSection load='6zn3' size='340' side='right'caption='[[6zn3]]' scene=''>	+	<StructureSection load='6zn3' size='340' side='right'caption='[[6zn3]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zn3]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZN3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6zn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zn3 OCA], [~~http~~://pdbe.org/6zn3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6zn3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6zn3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6zn3 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.51Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zn3 OCA], [https://pdbe.org/6zn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zn3 RCSB], [https://www.ebi.ac.uk/pdbsum/6zn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zn3 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8IJM4_PLAF7 Q8IJM4_PLAF7]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Gliding, a type of motility based on an actin-myosin motor, is specific to apicomplexan parasites. Myosin A binds two light chains which further interact with glideosome associated proteins and assemble into the glideosome. The role of individual glideosome proteins is unclear due to the lack of structures of larger glideosome assemblies. Here, we investigate the role of essential light chains (ELCs) in Toxoplasma gondii and Plasmodium falciparum and present their crystal structures as part of trimeric sub-complexes. We show that although ELCs bind a conserved MyoA sequence, P. falciparum ELC adopts a distinct structure in the free and MyoA-bound state. We suggest that ELCs enhance MyoA performance by inducing secondary structure in MyoA and thus stiffen its lever arm. Structural and biophysical analysis reveals that calcium binding has no influence on the structure of ELCs. Our work represents a further step towards understanding the mechanism of gliding in Apicomplexa.
		+
		+	Structural role of essential light chains in the apicomplexan glideosome.,Pazicky S, Dhamotharan K, Kaszuba K, Mertens HDT, Gilberger T, Svergun D, Kosinski J, Weininger U, Low C Commun Biol. 2020 Oct 13;3(1):568. doi: 10.1038/s42003-020-01283-8. PMID:33051581<ref>PMID:33051581</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6zn3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Plasmodium falciparum 3D7]]
		+	[[Category: Loew C]]
		+	[[Category: Pazicky S]]

OCA at 08:16, 21 October 2020

2020-10-21T08:16:22Z

←Older revision		Revision as of 08:16, 21 October 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6zn3 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6zn3' size='340' side='right'caption='[[6zn3]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zn3 OCA], [http://pdbe.org/6zn3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zn3 RCSB], [http://www.ebi.ac.uk/pdbsum/6zn3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zn3 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "6zn3" [edit=sysop:move=sysop]

2020-07-22T08:02:58Z

Protected "6zn3" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:02, 22 July 2020

OCA: New page: '''Unreleased structure''' The entry 6zn3 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2020-07-22T08:02:55Z

New page: '''Unreleased structure''' The entry 6zn3 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6zn3 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

6zn3 - Revision history

OCA at 11:54, 1 February 2024

OCA at 08:16, 21 October 2020

OCA: Protected "6zn3" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6zn3 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures