6zxl - Revision history

OCA at 07:43, 1 May 2024

2024-05-01T07:43:01Z

←Older revision		Revision as of 07:43, 1 May 2024
Line 1:		Line 1:

-	====	+	==Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1A) arrangement==
-	<StructureSection load='6zxl' size='340' side='right'caption='[[6zxl]]' scene=''>	+	<StructureSection load='6zxl' size='340' side='right'caption='[[6zxl]], [[Resolution\|resolution]] 4.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zxl]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZXL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6zxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zxl OCA], [~~http~~://pdbe.org/6zxl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6zxl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6zxl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6zxl ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zxl OCA], [https://pdbe.org/6zxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zxl RCSB], [https://www.ebi.ac.uk/pdbsum/6zxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zxl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LEF_BACAN LEF_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. LF is the lethal factor that, when associated with PA, causes death. LF is not toxic by itself. It is a protease that cleaves the N-terminal of most dual specificity mitogen-activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N-terminal proline-rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein-protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LeTx intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates.<ref>PMID:9563949</ref> <ref>PMID:9703991</ref> <ref>PMID:10475971</ref> <ref>PMID:11104681</ref> <ref>PMID:10338520</ref>
		+
		+	==See Also==
		+	*[[Anthrax lethal factor 3D structures\|Anthrax lethal factor 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus anthracis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Antoni C]]
		+	[[Category: Gatsogiannis C]]
		+	[[Category: Quentin D]]
		+	[[Category: Raunser S]]

OCA at 06:54, 2 September 2020

2020-09-02T06:54:04Z

←Older revision		Revision as of 06:54, 2 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6zxl ~~is ON HOLD~~	+	====
-		+	<StructureSection load='6zxl' size='340' side='right'caption='[[6zxl]]' scene=''>
-	~~Authors~~: ~~Quentin, D~~.~~, Antoni, C~~.~~, Gatsogiannis, C~~.~~, Raunser, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1A) arrangement~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zxl OCA], [http://pdbe.org/6zxl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zxl RCSB], [http://www.ebi.ac.uk/pdbsum/6zxl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zxl ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Antoni, C~~]]	+	__TOC__
-	[~~[Category~~: ~~Gatsogiannis~~, C]]	+	</StructureSection>
-	[[Category: ~~Quentin, D~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Raunser, S~~]]	+	[[Category: Z-disk]]

OCA: Protected "6zxl" [edit=sysop:move=sysop]

2020-08-05T04:03:42Z

Protected "6zxl" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:03, 5 August 2020

OCA: New page: '''Unreleased structure''' The entry 6zxl is ON HOLD Authors: Quentin, D., Antoni, C., Gatsogiannis, C., Raunser, S. Description: Fully-loaded anthrax lethal toxin in its heptameric pr...

2020-08-05T04:03:41Z

New page: '''Unreleased structure''' The entry 6zxl is ON HOLD Authors: Quentin, D., Antoni, C., Gatsogiannis, C., Raunser, S. Description: Fully-loaded anthrax lethal toxin in its heptameric pr...

New page

'''Unreleased structure'''

The entry 6zxl is ON HOLD

Authors: Quentin, D., Antoni, C., Gatsogiannis, C., Raunser, S.

Description: Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1A) arrangement
[[Category: Unreleased Structures]]
[[Category: Antoni, C]]
[[Category: Gatsogiannis, C]]
[[Category: Quentin, D]]
[[Category: Raunser, S]]