7a2n - Revision history

OCA at 12:02, 1 February 2024

2024-02-01T12:02:33Z

←Older revision		Revision as of 12:02, 1 February 2024
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	==Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21==		==Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21==
-	<StructureSection load='7a2n' size='340' side='right'caption='[[7a2n]]' scene=''>	+	<StructureSection load='7a2n' size='340' side='right'caption='[[7a2n]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A2N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7a2n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A2N FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a2n OCA], [https://pdbe.org/7a2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a2n RCSB], [https://www.ebi.ac.uk/pdbsum/7a2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a2n ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a2n OCA], [https://pdbe.org/7a2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a2n RCSB], [https://www.ebi.ac.uk/pdbsum/7a2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a2n ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FYN_HUMAN FYN_HUMAN] Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.<ref>PMID:7822789</ref> <ref>PMID:7568038</ref> <ref>PMID:11005864</ref> <ref>PMID:11162638</ref> <ref>PMID:11536198</ref> <ref>PMID:12788081</ref> <ref>PMID:12640114</ref> <ref>PMID:14761972</ref> <ref>PMID:15557120</ref> <ref>PMID:14707117</ref> <ref>PMID:15536091</ref> <ref>PMID:16387660</ref> <ref>PMID:16841086</ref> <ref>PMID:17194753</ref> <ref>PMID:18056706</ref> <ref>PMID:18258597</ref> <ref>PMID:19179337</ref> <ref>PMID:19652227</ref> <ref>PMID:20100835</ref>
		+
		+	==See Also==
		+	*[[Tyrosine kinase 3D structures\|Tyrosine kinase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Camara-Artigas A]]		[[Category: Camara-Artigas A]]
	[[Category: Plaza-Garrido M]]		[[Category: Plaza-Garrido M]]
	[[Category: Salinas-Garcia MC]]		[[Category: Salinas-Garcia MC]]

OCA at 06:16, 25 August 2021

2021-08-25T06:16:43Z

←Older revision		Revision as of 06:16, 25 August 2021
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-	'''Unreleased structure'''

-	~~The entry 7a2n is ON HOLD until Paper Publication~~	+	==Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21==
-		+	<StructureSection load='7a2n' size='340' side='right'caption='[[7a2n]]' scene=''>
-	~~Authors: Camara-Artigas, A., Plaza-Garrido, M., Salinas-Garcia, M.C.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A2N FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a2n OCA], [https://pdbe.org/7a2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a2n RCSB], [https://www.ebi.ac.uk/pdbsum/7a2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a2n ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Plaza~~-~~Garrido~~, M]]	+	__TOC__
-	[[Category: Camara-Artigas, A]]	+	</StructureSection>
-	[[Category: Salinas-Garcia~~, M.C~~]]	+	[[Category: Large Structures]]
		+	[[Category: Camara-Artigas A]]
		+	[[Category: Plaza-Garrido M]]
		+	[[Category: Salinas-Garcia MC]]

OCA at 06:37, 16 September 2020

2020-09-16T06:37:35Z

←Older revision		Revision as of 06:37, 16 September 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7a2n is ON HOLD	+	The entry 7a2n is ON HOLD until Paper Publication

	Authors: Camara-Artigas, A., Plaza-Garrido, M., Salinas-Garcia, M.C.		Authors: Camara-Artigas, A., Plaza-Garrido, M., Salinas-Garcia, M.C.
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	Description: Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21		Description: Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Salinas-Garcia, M.C]]
-	[[Category: Camara-Artigas, A]]
	[[Category: Plaza-Garrido, M]]		[[Category: Plaza-Garrido, M]]
		+	[[Category: Camara-Artigas, A]]
		+	[[Category: Salinas-Garcia, M.C]]

OCA: Protected "7a2n" [edit=sysop:move=sysop]

2020-08-26T09:13:52Z

Protected "7a2n" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:13, 26 August 2020

OCA: New page: '''Unreleased structure''' The entry 7a2n is ON HOLD Authors: Camara-Artigas, A., Plaza-Garrido, M., Salinas-Garcia, M.C. Description: Crystal structure of the Fyn SH3 domain A95S-D99T...

2020-08-26T09:13:50Z

New page: '''Unreleased structure''' The entry 7a2n is ON HOLD Authors: Camara-Artigas, A., Plaza-Garrido, M., Salinas-Garcia, M.C. Description: Crystal structure of the Fyn SH3 domain A95S-D99T...

New page

'''Unreleased structure'''

The entry 7a2n is ON HOLD

Authors: Camara-Artigas, A., Plaza-Garrido, M., Salinas-Garcia, M.C.

Description: Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21
[[Category: Unreleased Structures]]
[[Category: Salinas-Garcia, M.C]]
[[Category: Camara-Artigas, A]]
[[Category: Plaza-Garrido, M]]