7a9d - Revision history

OCA at 12:05, 1 February 2024

2024-02-01T12:05:30Z

←Older revision		Revision as of 12:05, 1 February 2024
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-	====	+	==Crystal structure of H12 Haemagglutinin==
-	<StructureSection load='7a9d' size='340' side='right'caption='[[7a9d]]' scene=''>	+	<StructureSection load='7a9d' size='340' side='right'caption='[[7a9d]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7a9d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/duck/Alberta/60/1976(H12N5)) Influenza A virus (A/duck/Alberta/60/1976(H12N5))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A9D FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a9d OCA], [https://pdbe.org/7a9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a9d RCSB], [https://www.ebi.ac.uk/pdbsum/7a9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a9d ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a9d OCA], [https://pdbe.org/7a9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a9d RCSB], [https://www.ebi.ac.uk/pdbsum/7a9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a9d ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HEMA_I76A2 HEMA_I76A2] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hemagglutinins (HAs) are the receptor-binding and membrane fusion glycoproteins of influenza viruses. They recognize sialic acid-containing, cell-surface glycoconjugates as receptors but have limited affinity for them, and, as a consequence, virus attachment to cells requires their interaction with several virus HAs. Receptor-bound virus is transferred into endosomes where membrane fusion by HAs is activated at pH between 5 and 6.5, depending on the strain of virus. Fusion activity requires extensive rearrangements in HA conformation that include extrusion of a buried "fusion peptide" to connect with the endosomal membrane, form a bridge to the virus membrane, and eventually bring both membranes close together. In this review, we give an overview of the structures of the 16 genetically and antigenically distinct subtypes of influenza A HA in relation to these two functions in virus replication and in relation to recognition of HA by antibodies that neutralize infection.
		+
		+	Hemagglutinin Structure and Activities.,Gamblin SJ, Vachieri SG, Xiong X, Zhang J, Martin SR, Skehel JJ Cold Spring Harb Perspect Med. 2021 Oct 1;11(10):a038638. doi: , 10.1101/cshperspect.a038638. PMID:32513673<ref>PMID:32513673</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7a9d" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Gamblin S]]
		+	[[Category: Skehel JJ]]
		+	[[Category: Walker P]]
		+	[[Category: Xiong X]]
		+	[[Category: Zhang J]]

OCA at 12:47, 13 October 2021

2021-10-13T12:47:09Z

←Older revision		Revision as of 12:47, 13 October 2021
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	<StructureSection load='7a9d' size='340' side='right'caption='[[7a9d]]' scene=''>		<StructureSection load='7a9d' size='340' side='right'caption='[[7a9d]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7a9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a9d OCA], [~~http~~://pdbe.org/7a9d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7a9d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7a9d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7a9d ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a9d OCA], [https://pdbe.org/7a9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a9d RCSB], [https://www.ebi.ac.uk/pdbsum/7a9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a9d ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 07:49, 2 December 2020

2020-12-02T07:49:16Z

←Older revision		Revision as of 07:49, 2 December 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7a9d ~~is ON HOLD until Oct 27 2021~~	+	====
-		+	<StructureSection load='7a9d' size='340' side='right'caption='[[7a9d]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7a9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a9d OCA], [http://pdbe.org/7a9d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7a9d RCSB], [http://www.ebi.ac.uk/pdbsum/7a9d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7a9d ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:16, 4 November 2020

2020-11-04T05:16:50Z

←Older revision		Revision as of 05:16, 4 November 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7a9d is ON HOLD	+	The entry 7a9d is ON HOLD until Oct 27 2021

	Authors:		Authors:

OCA: Protected "7a9d" [edit=sysop:move=sysop]

2020-09-09T07:19:44Z

Protected "7a9d" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:19, 9 September 2020

OCA: New page: '''Unreleased structure''' The entry 7a9d is ON HOLD Authors: Description: Category: Unreleased Structures

2020-09-09T07:19:43Z

New page: '''Unreleased structure''' The entry 7a9d is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7a9d is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]