7acv - Revision history

OCA at 12:07, 1 February 2024

2024-02-01T12:07:23Z

←Older revision		Revision as of 12:07, 1 February 2024
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-	====	+	==SLPL/HID (LMW SLP complex with HMW SLP interacting domain - HID) from C. difficile (R7404 strain)==
-	<StructureSection load='7acv' size='340' side='right'caption='[[7acv]]' scene=''>	+	<StructureSection load='7acv' size='340' side='right'caption='[[7acv]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7acv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile Clostridioides difficile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ACV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ACV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7acv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7acv OCA], [https://pdbe.org/7acv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7acv RCSB], [https://www.ebi.ac.uk/pdbsum/7acv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7acv ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7acv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7acv OCA], [https://pdbe.org/7acv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7acv RCSB], [https://www.ebi.ac.uk/pdbsum/7acv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7acv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9AEM2_CLODI Q9AEM2_CLODI]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many bacteria and archaea possess a two-dimensional protein array, or S-layer, that covers the cell surface and plays crucial roles in cell physiology. Here, we report the crystal structure of SlpA, the main S-layer protein of the bacterial pathogen Clostridioides difficile, and use electron microscopy to study S-layer organisation and assembly. The SlpA crystal lattice mimics S-layer assembly in the cell, through tiling of triangular prisms above the cell wall, interlocked by distinct ridges facing the environment. Strikingly, the array is very compact, with pores of only ~10 A in diameter, compared to other S-layers (30-100 A). The surface-exposed flexible ridges are partially dispensable for overall structure and assembly, although a mutant lacking this region becomes susceptible to lysozyme, an important molecule in host defence. Thus, our work gives insights into S-layer organisation and provides a basis for development of C. difficile-specific therapeutics.
		+
		+	Structure and assembly of the S-layer in C. difficile.,Lanzoni-Mangutchi P, Banerji O, Wilson J, Barwinska-Sendra A, Kirk JA, Vaz F, O'Beirne S, Basle A, El Omari K, Wagner A, Fairweather NF, Douce GR, Bullough PA, Fagan RP, Salgado PS Nat Commun. 2022 Feb 25;13(1):970. doi: 10.1038/s41467-022-28196-w. PMID:35217634<ref>PMID:35217634</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7acv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Clostridioides difficile]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z-~~disk~~]]	+	[[Category: Barwinska-Sendra A]]
		+	[[Category: Lanzoni-Mangutchi P]]
		+	[[Category: Salgado PS]]

OCA at 06:04, 9 March 2022

2022-03-09T06:04:16Z

←Older revision		Revision as of 06:04, 9 March 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7acv ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7acv' size='340' side='right'caption='[[7acv]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7acv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7acv OCA], [https://pdbe.org/7acv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7acv RCSB], [https://www.ebi.ac.uk/pdbsum/7acv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7acv ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 04:57, 1 December 2021

2021-12-01T04:57:50Z

←Older revision		Revision as of 04:57, 1 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7acv is ON HOLD	+	The entry 7acv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 11:55, 17 November 2021

2021-11-17T11:55:11Z

←Older revision		Revision as of 11:55, 17 November 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7acv is ON HOLD ~~until Paper Publication~~	+	The entry 7acv is ON HOLD

	Authors:		Authors:

OCA at 03:59, 14 October 2020

2020-10-14T03:59:49Z

←Older revision		Revision as of 03:59, 14 October 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7acv is ON HOLD	+	The entry 7acv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7acv" [edit=sysop:move=sysop]

2020-09-23T08:41:56Z

Protected "7acv" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:41, 23 September 2020

OCA: New page: '''Unreleased structure''' The entry 7acv is ON HOLD Authors: Description: Category: Unreleased Structures

2020-09-23T08:41:54Z

New page: '''Unreleased structure''' The entry 7acv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7acv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]