OCA at 12:08, 1 February 2024

2024-02-01T12:08:11Z

←Older revision		Revision as of 12:08, 1 February 2024
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-	====	+	==Human ARTD2 in complex with DNA oligonucleotides==
-	<StructureSection load='7aeo' size='340' side='right'caption='[[7aeo]]' scene=''>	+	<StructureSection load='7aeo' size='340' side='right'caption='[[7aeo]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7aeo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AEO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aeo OCA], [https://pdbe.org/7aeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aeo RCSB], [https://www.ebi.ac.uk/pdbsum/7aeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aeo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aeo OCA], [https://pdbe.org/7aeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aeo RCSB], [https://www.ebi.ac.uk/pdbsum/7aeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aeo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PARP2_HUMAN PARP2_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human PARP2/ARTD2 is an ADP-ribosyltransferase which, when activated by 5'-phosphorylated DNA ends, catalyses poly-ADP-ribosylation of itself, other proteins and DNA. In this study, a crystal structure of PARP2 in complex with an activating 5'-phosphorylated DNA shows that the WGR domain bridges the dsDNA gap and joins the DNA ends. This DNA binding results in major conformational changes, including reorganization of helical fragments, in the PARP2 regulatory domain. A comparison of PARP1 and PARP2 crystal structures reveals how binding to a DNA damage site leads to formation of a catalytically competent conformation. In this conformation, PARP2 is capable of binding substrate NAD(+) and histone PARylation factor 1 that changes PARP2 residue specificity from glutamate to serine when initiating DNA repair processes. The structure also reveals how the conformational changes in the autoinhibitory regulatory domain would promote the flexibility needed by the enzyme to reach the target macromolecule for ADP-ribosylation.
		+
		+	Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition.,Obaji E, Maksimainen MM, Galera-Prat A, Lehtio L Nat Commun. 2021 Jun 9;12(1):3479. doi: 10.1038/s41467-021-23800-x. PMID:34108479<ref>PMID:34108479</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7aeo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z-~~disk~~]]	+	[[Category: Synthetic construct]]
		+	[[Category: Galera-Prat A]]
		+	[[Category: Lehtio L]]
		+	[[Category: Maksimainen MM]]
		+	[[Category: Obaji E]]

OCA at 10:07, 19 May 2021

2021-05-19T10:07:50Z

←Older revision		Revision as of 10:07, 19 May 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7aeo ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7aeo' size='340' side='right'caption='[[7aeo]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aeo OCA], [https://pdbe.org/7aeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aeo RCSB], [https://www.ebi.ac.uk/pdbsum/7aeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aeo ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7aeo" [edit=sysop:move=sysop]

2020-09-23T08:48:34Z

Protected "7aeo" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:48, 23 September 2020

OCA: New page: '''Unreleased structure''' The entry 7aeo is ON HOLD Authors: Description: Category: Unreleased Structures

2020-09-23T08:48:32Z

New page: '''Unreleased structure''' The entry 7aeo is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7aeo is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7aeo - Revision history

OCA at 12:08, 1 February 2024

OCA at 10:07, 19 May 2021

OCA: Protected "7aeo" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7aeo is ON HOLD Authors: Description: Category: Unreleased Structures