7atz - Revision history

OCA at 05:30, 28 April 2021

2021-04-28T05:30:55Z

←Older revision		Revision as of 05:30, 28 April 2021
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	==G-quadruplex with V-shaped loop from the first repeat of KCNN4 minisatellite==		==G-quadruplex with V-shaped loop from the first repeat of KCNN4 minisatellite==
-	<StructureSection load='7atz' size='340' side='right'caption='[[7atz]]' scene=''>	+	<StructureSection load='7atz' size='340' side='right'caption='[[7atz]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ATZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ATZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7atz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ATZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ATZ FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7atz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7atz OCA], [https://pdbe.org/7atz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7atz RCSB], [https://www.ebi.ac.uk/pdbsum/7atz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7atz ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7atz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7atz OCA], [https://pdbe.org/7atz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7atz RCSB], [https://www.ebi.ac.uk/pdbsum/7atz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7atz ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The KCNN4 gene encoding a potassium channel protein whose expression has been correlated with tumor progression was found to comprise a guanine-rich minisatellite region with the ability to form a putative G-quadruplex (G4). Given the suggested regulatory role of G4s in gene expression, G-quadruplex formation for the polymorphic first repeat of the minisatellite was studied by nuclear magnetic resonance spectroscopy. A stable G-quadruplex of a truncated mutant sequence was shown to represent one of several coexisting species of the wild-type sequence. The high-resolution structure features a noncanonical G4 with a broken G-column and a V-shaped loop. The presence of a 3'-flanking thymidine interacting with the lateral loop preceding the V loop seems to be critical for the formation of this G4 topology. On the contrary, an additional 5'-flanking residue disfavored but still allowed folding into the V-loop structure. The latter may therefore serve as a putative therapeutic target in strategies for G4-based modulation of KCNN4 expression.
		+
		+	First Tandem Repeat of a Potassium Channel KCNN4 Minisatellite Folds into a V-Loop G-Quadruplex Structure.,Vianney YM, Weisz K Biochemistry. 2021 Apr 12. doi: 10.1021/acs.biochem.1c00043. PMID:33844501<ref>PMID:33844501</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7atz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Vianney YM]]	+	[[Category: Vianney, Y M]]
-	[[Category: Weisz K]]	+	[[Category: Weisz, K]]
		+	[[Category: Dna]]
		+	[[Category: G-quadruplex]]
		+	[[Category: V-loop]]

OCA at 08:21, 21 April 2021

2021-04-21T08:21:30Z

←Older revision		Revision as of 08:21, 21 April 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7atz ~~is ON HOLD until Paper Publication~~	+	==G-quadruplex with V-shaped loop from the first repeat of KCNN4 minisatellite==
-		+	<StructureSection load='7atz' size='340' side='right'caption='[[7atz]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ATZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ATZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7atz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7atz OCA], [https://pdbe.org/7atz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7atz RCSB], [https://www.ebi.ac.uk/pdbsum/7atz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7atz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Vianney YM]]
		+	[[Category: Weisz K]]

OCA: Protected "7atz" [edit=sysop:move=sysop]

2020-11-11T06:16:46Z

Protected "7atz" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:16, 11 November 2020

OCA: New page: '''Unreleased structure''' The entry 7atz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2020-11-11T06:16:44Z

New page: '''Unreleased structure''' The entry 7atz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7atz is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]