7b57 - Revision history

OCA at 12:22, 1 February 2024

2024-02-01T12:22:06Z

←Older revision		Revision as of 12:22, 1 February 2024
Line 1:		Line 1:

-	====	+	==Crystal structure of CaMKII-actinin complex bound to ADP==
-	<StructureSection load='7b57' size='340' side='right'caption='[[7b57]]' scene=''>	+	<StructureSection load='7b57' size='340' side='right'caption='[[7b57]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7b57]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B57 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b57 OCA], [https://pdbe.org/7b57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b57 RCSB], [https://www.ebi.ac.uk/pdbsum/7b57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b57 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b57 OCA], [https://pdbe.org/7b57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b57 RCSB], [https://www.ebi.ac.uk/pdbsum/7b57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b57 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KCC2A_MOUSE KCC2A_MOUSE] Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (By similarity). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (By similarity). Also regulates the migration of developing neurons (By similarity). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (PubMed:15994560). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (PubMed:23502535).[UniProtKB:P11275][UniProtKB:Q9UQM7]<ref>PMID:15994560</ref> <ref>PMID:23502535</ref> <ref>PMID:23805378</ref> Has no kinase activity.<ref>PMID:8524307</ref>
		+
		+	==See Also==
		+	*[[Actinin 3D structures\|Actinin 3D structures]]
		+	*[[Calcium/calmodulin dependent protein kinase 3D structures\|Calcium/calmodulin dependent protein kinase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Gold M]]
		+	[[Category: Zhu J]]

OCA at 09:42, 22 June 2022

2022-06-22T09:42:28Z

←Older revision		Revision as of 09:42, 22 June 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7b57 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7b57' size='340' side='right'caption='[[7b57]]' scene=''>
-	~~Authors~~: ~~Zhu, J~~.~~, Gold, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of CaMKII~~-~~actinin complex bound to ADP~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b57 OCA], [https://pdbe.org/7b57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b57 RCSB], [https://www.ebi.ac.uk/pdbsum/7b57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b57 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Zhu, J~~]]	+	__TOC__
-	[[Category: ~~Gold, M~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:28, 6 January 2021

2021-01-06T05:28:56Z

←Older revision		Revision as of 05:28, 6 January 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7b57 is ON HOLD	+	The entry 7b57 is ON HOLD until Paper Publication

	Authors: Zhu, J., Gold, M.		Authors: Zhu, J., Gold, M.

OCA: Protected "7b57" [edit=sysop:move=sysop]

2020-12-09T05:04:10Z

Protected "7b57" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:04, 9 December 2020

OCA: New page: '''Unreleased structure''' The entry 7b57 is ON HOLD Authors: Zhu, J., Gold, M. Description: Crystal structure of CaMKII-actinin complex bound to ADP [[Category: Unreleased Structures]...

2020-12-09T05:04:09Z

New page: '''Unreleased structure''' The entry 7b57 is ON HOLD Authors: Zhu, J., Gold, M. Description: Crystal structure of CaMKII-actinin complex bound to ADP [[Category: Unreleased Structures]...

New page

'''Unreleased structure'''

The entry 7b57 is ON HOLD

Authors: Zhu, J., Gold, M.

Description: Crystal structure of CaMKII-actinin complex bound to ADP
[[Category: Unreleased Structures]]
[[Category: Zhu, J]]
[[Category: Gold, M]]