OCA at 12:26, 1 February 2024

2024-02-01T12:26:15Z

←Older revision		Revision as of 12:26, 1 February 2024
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-	====	+	==Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ATPgammaS==
-	<StructureSection load='7bdj' size='340' side='right'caption='[[7bdj]]' scene=''>	+	<StructureSection load='7bdj' size='340' side='right'caption='[[7bdj]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bdj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BDJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bdj OCA], [https://pdbe.org/7bdj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bdj RCSB], [https://www.ebi.ac.uk/pdbsum/7bdj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bdj ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.59Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TGB:[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-[2-(methylamino)phenyl]carbonyloxy-4-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-sulfanyl-phosphinic+acid'>TGB</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bdj OCA], [https://pdbe.org/7bdj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bdj RCSB], [https://www.ebi.ac.uk/pdbsum/7bdj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bdj ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/U520_HUMAN U520_HUMAN] Retinitis pigmentosa. Retinitis pigmentosa 33 (RP33) [MIM:[https://omim.org/entry/610359 610359]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16723661</ref> <ref>PMID:23045696</ref> <ref>PMID:19878916</ref> <ref>PMID:19710410</ref> <ref>PMID:21618346</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/U520_HUMAN U520_HUMAN] RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.<ref>PMID:16723661</ref> <ref>PMID:8670905</ref> <ref>PMID:9539711</ref> <ref>PMID:23045696</ref>
		+
		+	==See Also==
		+	*[[Helicase 3D structures\|Helicase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Absmeier E]]
		+	[[Category: Santos KF]]
		+	[[Category: Vester K]]
		+	[[Category: Wahl MC]]

OCA at 12:12, 9 June 2021

2021-06-09T12:12:01Z

←Older revision		Revision as of 12:12, 9 June 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7bdj ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7bdj' size='340' side='right'caption='[[7bdj]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bdj OCA], [https://pdbe.org/7bdj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bdj RCSB], [https://www.ebi.ac.uk/pdbsum/7bdj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bdj ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 08:32, 17 February 2021

2021-02-17T08:32:45Z

←Older revision		Revision as of 08:32, 17 February 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7bdj is ON HOLD	+	The entry 7bdj is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7bdj" [edit=sysop:move=sysop]

2020-12-30T05:17:47Z

Protected "7bdj" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:17, 30 December 2020

OCA: New page: '''Unreleased structure''' The entry 7bdj is ON HOLD Authors: Description: Category: Unreleased Structures

2020-12-30T05:17:46Z

New page: '''Unreleased structure''' The entry 7bdj is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7bdj is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7bdj - Revision history

OCA at 12:26, 1 February 2024

OCA at 12:12, 9 June 2021

OCA at 08:32, 17 February 2021

OCA: Protected "7bdj" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7bdj is ON HOLD Authors: Description: Category: Unreleased Structures