7bw5 - Revision history

OCA at 11:11, 14 June 2023

2023-06-14T11:11:32Z

←Older revision		Revision as of 11:11, 14 June 2023
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	==a new lasso peptide koreensin==		==a new lasso peptide koreensin==
-	<StructureSection load='7bw5' size='340' side='right'caption='[[7bw5~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='7bw5' size='340' side='right'caption='[[7bw5]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7bw5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Dsm_15582 Dsm 15582~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BW5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7BW5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bw5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingomonas_koreensis Sphingomonas koreensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BW5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7bw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bw5 OCA], [~~http~~://pdbe.org/7bw5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7bw5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7bw5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7bw5 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bw5 OCA], [https://pdbe.org/7bw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bw5 RCSB], [https://www.ebi.ac.uk/pdbsum/7bw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bw5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A2M8WFL4_9SPHN A0A2M8WFL4_9SPHN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dsm 15582]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hemmi, H~~]]	+	[[Category: Sphingomonas koreensis]]
-	[[Category: ~~Kodani, S~~]]	+	[[Category: Hemmi H]]
-	[[Category: ~~Lasso peptide]]~~	+	[[Category: Kodani S]]
-	~~[[Category: Unknown function~~]]	+

OCA at 11:05, 24 December 2020

2020-12-24T11:05:50Z

←Older revision		Revision as of 11:05, 24 December 2020
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	==a new lasso peptide koreensin==		==a new lasso peptide koreensin==
-	<StructureSection load='7bw5' size='340' side='right'caption='[[7bw5]]' scene=''>	+	<StructureSection load='7bw5' size='340' side='right'caption='[[7bw5]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BW5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BW5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bw5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_15582 Dsm 15582]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BW5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BW5 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7bw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bw5 OCA], [http://pdbe.org/7bw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7bw5 RCSB], [http://www.ebi.ac.uk/pdbsum/7bw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7bw5 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7bw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bw5 OCA], [http://pdbe.org/7bw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7bw5 RCSB], [http://www.ebi.ac.uk/pdbsum/7bw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7bw5 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lasso peptides are a class of ribosomally biosynthesized and posttranslationally modified peptides with a knot structure as a common motif. Based on a genome search, a new biosynthetic gene cluster of lasso peptide was found in the genome of the proteobacterium Sphingomonas koreensis. Interestingly, the amino acid sequence of the precursor peptide gene includes two cell adhesion motif sequences (KGD and DGR). Heterologous production of the new lasso peptide was performed using the cryptic biosynthetic gene cluster of S. koreensis. As a result, a new lasso peptide named koreensin was produced by the gene expression system in the host strain Sphingomonas subterranea. The structure of koreensin was determined by NMR and ESI-MS analysis. The three-dimensional structure of koreensin was obtained based on an NOE experiment and the coupling constants. A variant peptide (koreensin-RGD), which had RGD instead of KGD, was produced by heterologous production with site-directed mutagenesis experiment. Koreensin and koreensin-RGD did not show cell adhesion inhibitory activity, although the molecules possessed cell adhesion motifs. The possible presence of a salt bridge between the motifs in koreensin was indicated, and it may prevent the cell adhesion motif from functioning.
		+
		+	Heterologous production of new lasso peptide koreensin based on genome mining.,Fuwa H, Hemmi H, Kaweewan I, Kozaki I, Honda H, Kodani S J Antibiot (Tokyo). 2020 Aug 27. pii: 10.1038/s41429-020-00363-5. doi:, 10.1038/s41429-020-00363-5. PMID:32855516<ref>PMID:32855516</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7bw5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dsm 15582]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hemmi H]]	+	[[Category: Hemmi, H]]
-	[[Category: Kodani S]]	+	[[Category: Kodani, S]]
		+	[[Category: Lasso peptide]]
		+	[[Category: Unknown function]]

OCA at 09:37, 9 September 2020

2020-09-09T09:37:07Z

←Older revision		Revision as of 09:37, 9 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7bw5 ~~is ON HOLD until Paper Publication~~	+	==a new lasso peptide koreensin==
-		+	<StructureSection load='7bw5' size='340' side='right'caption='[[7bw5]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BW5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BW5 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7bw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bw5 OCA], [http://pdbe.org/7bw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7bw5 RCSB], [http://www.ebi.ac.uk/pdbsum/7bw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7bw5 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hemmi H]]
		+	[[Category: Kodani S]]

OCA: Protected "7bw5" [edit=sysop:move=sysop]

2020-04-22T04:37:30Z

Protected "7bw5" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:37, 22 April 2020

OCA: New page: '''Unreleased structure''' The entry 7bw5 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2020-04-22T04:37:29Z

New page: '''Unreleased structure''' The entry 7bw5 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7bw5 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]