7by6 - Revision history

OCA at 15:40, 29 November 2023

2023-11-29T15:40:31Z

←Older revision		Revision as of 15:40, 29 November 2023
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-	====	+	==Plasmodium vivax cytoplasmic Phenylalanyl-tRNA synthetase in complex with BRD1389==
-	<StructureSection load='7by6' size='340' side='right'caption='[[7by6]]' scene=''>	+	<StructureSection load='7by6' size='340' side='right'caption='[[7by6]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7by6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BY6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7by6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7by6 OCA], [https://pdbe.org/7by6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7by6 RCSB], [https://www.ebi.ac.uk/pdbsum/7by6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7by6 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.997Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FB9:(3S,4R,8R,9R,10S)-N-(4-cyclopropyloxyphenyl)-10-(methoxymethyl)-3,4-bis(oxidanyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide'>FB9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7by6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7by6 OCA], [https://pdbe.org/7by6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7by6 RCSB], [https://www.ebi.ac.uk/pdbsum/7by6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7by6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SYFB_PLAVS SYFB_PLAVS]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The inhibition of Plasmodium cytosolic phenylalanine tRNA-synthetase (cFRS) by a novel series of bicyclic azetidines has shown the potential to prevent malaria transmission, provide prophylaxis, and offer single-dose cure in animal models of malaria. To date, however, the molecular basis of Plasmodium cFRS inhibition by bicyclic azetidines has remained unknown. Here, we present structural and biochemical evidence that bicyclic azetidines are competitive inhibitors of L-Phe, one of three substrates required for the cFRS-catalyzed aminoacylation reaction that underpins protein synthesis in the parasite. Critically, our co-crystal structure of a PvcFRS-BRD1389 complex shows that the bicyclic azetidine ligand binds to two distinct sub-sites within the PvcFRS catalytic site. The ligand occupies the L-Phe site along with an auxiliary cavity and traverses past the ATP binding site. Given that BRD1389 recognition residues are conserved amongst apicomplexan FRSs, this work lays a structural framework for the development of drugs against both Plasmodium and related apicomplexans.
		+
		+	Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.,Sharma M, Malhotra N, Yogavel M, Harlos K, Melillo B, Comer E, Gonse A, Parvez S, Mitasev B, Fang FG, Schreiber SL, Sharma A Nat Commun. 2021 Jan 12;12(1):343. doi: 10.1038/s41467-020-20478-5. PMID:33436639<ref>PMID:33436639</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7by6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Plasmodium vivax]]
		+	[[Category: Harlos K]]
		+	[[Category: Malhotra N]]
		+	[[Category: Manickam Y]]
		+	[[Category: Manmohan S]]
		+	[[Category: Melillo B]]
		+	[[Category: Schreiber SL]]
		+	[[Category: Sharma S]]

OCA at 08:02, 27 January 2021

2021-01-27T08:02:22Z

←Older revision		Revision as of 08:02, 27 January 2021
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	<StructureSection load='7by6' size='340' side='right'caption='[[7by6]]' scene=''>		<StructureSection load='7by6' size='340' side='right'caption='[[7by6]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7by6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7by6 OCA], [~~http~~://pdbe.org/7by6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7by6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7by6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7by6 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7by6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7by6 OCA], [https://pdbe.org/7by6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7by6 RCSB], [https://www.ebi.ac.uk/pdbsum/7by6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7by6 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 07:25, 4 November 2020

2020-11-04T07:25:32Z

←Older revision		Revision as of 07:25, 4 November 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7by6 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7by6' size='340' side='right'caption='[[7by6]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7by6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7by6 OCA], [http://pdbe.org/7by6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7by6 RCSB], [http://www.ebi.ac.uk/pdbsum/7by6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7by6 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 06:46, 16 September 2020

2020-09-16T06:46:04Z

←Older revision		Revision as of 06:46, 16 September 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7by6 is ON HOLD	+	The entry 7by6 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7by6" [edit=sysop:move=sysop]

2020-04-29T05:37:45Z

Protected "7by6" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:37, 29 April 2020

OCA: New page: '''Unreleased structure''' The entry 7by6 is ON HOLD Authors: Description: Category: Unreleased Structures

2020-04-29T05:37:44Z

New page: '''Unreleased structure''' The entry 7by6 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7by6 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]