7byn - Revision history

OCA at 10:49, 27 March 2024

2024-03-27T10:49:56Z

←Older revision		Revision as of 10:49, 27 March 2024
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-	====	+	==Cryo-EM structure of human KCNQ4 with linopirdine==
-	<StructureSection load='7byn' size='340' side='right'caption='[[7byn]]' scene=''>	+	<StructureSection load='7byn' size='340' side='right'caption='[[7byn]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7byn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BYN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7byn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7byn OCA], [https://pdbe.org/7byn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7byn RCSB], [https://www.ebi.ac.uk/pdbsum/7byn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7byn ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FCC:1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one'>FCC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PT5:(1S)-2-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}-1-[(OCTADECANOYLOXY)METHYL]ETHYL+(8E,11E)-ICOSA-5,8,11,14-TETRAENOATE'>PT5</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7byn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7byn OCA], [https://pdbe.org/7byn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7byn RCSB], [https://www.ebi.ac.uk/pdbsum/7byn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7byn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/KCNQ4_HUMAN KCNQ4_HUMAN] Defects in KCNQ4 are the cause of deafness autosomal dominant type 2A (DFNA2A) [MIM:[https://omim.org/entry/600101 600101]. DFNA2A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:10025409</ref> <ref>PMID:10369879</ref> <ref>PMID:10571947</ref> <ref>PMID:10925378</ref> <ref>PMID:21242547</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KCNQ4_HUMAN KCNQ4_HUMAN] Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.<ref>PMID:11245603</ref> [https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
		+
		+	==See Also==
		+	*[[Calmodulin 3D structures\|Calmodulin 3D structures]]
		+	*[[Green Fluorescent Protein 3D structures\|Green Fluorescent Protein 3D structures]]
		+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aequorea victoria]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z~~-disk~~]]	+	[[Category: Li T]]
		+	[[Category: Shen H]]
		+	[[Category: Yue Z]]

OCA at 08:02, 27 January 2021

2021-01-27T08:02:25Z

←Older revision		Revision as of 08:02, 27 January 2021
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	<StructureSection load='7byn' size='340' side='right'caption='[[7byn]]' scene=''>		<StructureSection load='7byn' size='340' side='right'caption='[[7byn]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7byn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7byn OCA], [~~http~~://pdbe.org/7byn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7byn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7byn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7byn ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7byn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7byn OCA], [https://pdbe.org/7byn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7byn RCSB], [https://www.ebi.ac.uk/pdbsum/7byn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7byn ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 07:54, 2 December 2020

2020-12-02T07:54:25Z

←Older revision		Revision as of 07:54, 2 December 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7byn ~~is ON HOLD until Apr 23 2022~~	+	====
-		+	<StructureSection load='7byn' size='340' side='right'caption='[[7byn]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7byn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7byn OCA], [http://pdbe.org/7byn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7byn RCSB], [http://www.ebi.ac.uk/pdbsum/7byn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7byn ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 08:58, 17 June 2020

2020-06-17T08:58:14Z

←Older revision		Revision as of 08:58, 17 June 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7byn is ON HOLD	+	The entry 7byn is ON HOLD until Apr 23 2022

	Authors:		Authors:

OCA: Protected "7byn" [edit=sysop:move=sysop]

2020-04-29T05:39:13Z

Protected "7byn" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:39, 29 April 2020

OCA: New page: '''Unreleased structure''' The entry 7byn is ON HOLD Authors: Description: Category: Unreleased Structures

2020-04-29T05:39:11Z

New page: '''Unreleased structure''' The entry 7byn is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7byn is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]