OCA at 15:59, 29 November 2023

2023-11-29T15:59:24Z

←Older revision		Revision as of 15:59, 29 November 2023
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-	====	+	==Structural basis for cross-species recognition of COVID-19 virus spike receptor binding domain to bat ACE2==
-	<StructureSection load='7c8j' size='340' side='right'caption='[[7c8j]]' scene=''>	+	<StructureSection load='7c8j' size='340' side='right'caption='[[7c8j]], [[Resolution\|resolution]] 3.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7c8j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhinolophus_macrotis Rhinolophus macrotis] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C8J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c8j OCA], [https://pdbe.org/7c8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c8j RCSB], [https://www.ebi.ac.uk/pdbsum/7c8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c8j ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.18Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c8j OCA], [https://pdbe.org/7c8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c8j RCSB], [https://www.ebi.ac.uk/pdbsum/7c8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c8j ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/E2DHI3_RHIMR E2DHI3_RHIMR]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a major threat to global health. Although varied SARS-CoV-2-related coronaviruses have been isolated from bats and SARS-CoV-2 may infect bat, the structural basis for SARS-CoV-2 to utilize the human receptor counterpart bat angiotensin-converting enzyme 2 (bACE2) for virus infection remains less understood. Here, we report that the SARS-CoV-2 spike protein receptor binding domain (RBD) could bind to bACE2 from Rhinolophus macrotis (bACE2-Rm) with substantially lower affinity compared with that to the human ACE2 (hACE2), and its infectivity to host cells expressing bACE2-Rm was confirmed with pseudotyped SARS-CoV-2 virus and SARS-CoV-2 wild virus. The structure of the SARS-CoV-2 RBD with the bACE2-Rm complex was determined, revealing a binding mode similar to that of hACE2. The analysis of binding details between SARS-CoV-2 RBD and bACE2-Rm revealed that the interacting network involving Y41 and E42 of bACE2-Rm showed substantial differences with that to hACE2. Bats have extensive species diversity and the residues for RBD binding in bACE2 receptor varied substantially among different bat species. Notably, the Y41H mutant, which exists in many bats, attenuates the binding capacity of bACE2-Rm, indicating the central roles of Y41 in the interaction network. These findings would benefit our understanding of the potential infection of SARS-CoV-2 in varied species of bats.
		+
		+	Cross-species recognition of SARS-CoV-2 to bat ACE2.,Liu K, Tan S, Niu S, Wang J, Wu L, Sun H, Zhang Y, Pan X, Qu X, Du P, Meng Y, Jia Y, Chen Q, Deng C, Yan J, Wang HW, Wang Q, Qi J, Gao GF Proc Natl Acad Sci U S A. 2021 Jan 5;118(1). pii: 2020216118. doi:, 10.1073/pnas.2020216118. PMID:33335073<ref>PMID:33335073</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7c8j" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Angiotensin-Converting Enzyme 3D structures\|Angiotensin-Converting Enzyme 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Rhinolophus macrotis]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Chen Q]]
		+	[[Category: Gao GF]]
		+	[[Category: Liu KF]]
		+	[[Category: Meng YM]]
		+	[[Category: Niu S]]
		+	[[Category: Pan XQ]]
		+	[[Category: Qi JX]]
		+	[[Category: Tan SG]]
		+	[[Category: Wang HW]]
		+	[[Category: Wang J]]
		+	[[Category: Wang QH]]
		+	[[Category: Wu LL]]
		+	[[Category: Zhang YF]]

OCA at 07:56, 27 January 2021

2021-01-27T07:56:57Z

←Older revision		Revision as of 07:56, 27 January 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7c8j ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7c8j' size='340' side='right'caption='[[7c8j]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c8j OCA], [https://pdbe.org/7c8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c8j RCSB], [https://www.ebi.ac.uk/pdbsum/7c8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c8j ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 11:22, 8 July 2020

2020-07-08T11:22:14Z

←Older revision		Revision as of 11:22, 8 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7c8j is ON HOLD	+	The entry 7c8j is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7c8j" [edit=sysop:move=sysop]

2020-06-10T05:18:17Z

Protected "7c8j" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:18, 10 June 2020

OCA: New page: '''Unreleased structure''' The entry 7c8j is ON HOLD Authors: Description: Category: Unreleased Structures

2020-06-10T05:18:16Z

New page: '''Unreleased structure''' The entry 7c8j is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7c8j is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7c8j - Revision history

OCA at 15:59, 29 November 2023

OCA at 07:56, 27 January 2021

OCA at 11:22, 8 July 2020

OCA: Protected "7c8j" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7c8j is ON HOLD Authors: Description: Category: Unreleased Structures