7c9a - Revision history

OCA at 10:50, 27 March 2024

2024-03-27T10:50:40Z

←Older revision		Revision as of 10:50, 27 March 2024
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-	====	+	==Human RAD51 post-synaptic complexes mutant (V273P, D274G)==
-	<StructureSection load='7c9a' size='340' side='right'caption='[[7c9a]]' scene=''>	+	<StructureSection load='7c9a' size='340' side='right'caption='[[7c9a]], [[Resolution\|resolution]] 3.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7c9a]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C9A FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c9a OCA], [https://pdbe.org/7c9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c9a RCSB], [https://www.ebi.ac.uk/pdbsum/7c9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c9a ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.43Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c9a OCA], [https://pdbe.org/7c9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c9a RCSB], [https://www.ebi.ac.uk/pdbsum/7c9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c9a ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/RAD51_HUMAN RAD51_HUMAN] Defects in RAD51 are a cause of susceptibility to breast cancer (BC) [MIM:[https://omim.org/entry/114480 114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.<ref>PMID:10807537</ref> Defects in RAD51 are the cause of mirror movements type 2 (MRMV2) [MIM:[https://omim.org/entry/614508 614508]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:22305526</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RAD51_HUMAN RAD51_HUMAN] Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.<ref>PMID:18417535</ref> <ref>PMID:12205100</ref> <ref>PMID:20413593</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Chi HY]]
		+	[[Category: Ho MC]]
		+	[[Category: Luo SC]]
		+	[[Category: Tsai MD]]
		+	[[Category: Yeh HY]]

OCA at 06:59, 17 March 2021

2021-03-17T06:59:08Z

←Older revision		Revision as of 06:59, 17 March 2021
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	<StructureSection load='7c9a' size='340' side='right'caption='[[7c9a]]' scene=''>		<StructureSection load='7c9a' size='340' side='right'caption='[[7c9a]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7c9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c9a OCA], [~~http~~://pdbe.org/7c9a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7c9a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7c9a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7c9a ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c9a OCA], [https://pdbe.org/7c9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c9a RCSB], [https://www.ebi.ac.uk/pdbsum/7c9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c9a ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 09:41, 18 November 2020

2020-11-18T09:41:03Z

←Older revision		Revision as of 09:41, 18 November 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7c9a ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7c9a' size='340' side='right'caption='[[7c9a]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7c9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c9a OCA], [http://pdbe.org/7c9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7c9a RCSB], [http://www.ebi.ac.uk/pdbsum/7c9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7c9a ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 04:06, 5 August 2020

2020-08-05T04:06:23Z

←Older revision		Revision as of 04:06, 5 August 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7c9a is ON HOLD	+	The entry 7c9a is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7c9a" [edit=sysop:move=sysop]

2020-06-10T05:20:27Z

Protected "7c9a" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:20, 10 June 2020

OCA: New page: '''Unreleased structure''' The entry 7c9a is ON HOLD Authors: Description: Category: Unreleased Structures

2020-06-10T05:20:26Z

New page: '''Unreleased structure''' The entry 7c9a is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7c9a is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]