OCA at 11:12, 14 June 2023

2023-06-14T11:12:03Z

←Older revision		Revision as of 11:12, 14 June 2023
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	<StructureSection load='7cjw' size='340' side='right'caption='[[7cjw]]' scene=''>		<StructureSection load='7cjw' size='340' side='right'caption='[[7cjw]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CJW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7cjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CJW FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cjw OCA], [https://pdbe.org/7cjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cjw RCSB], [https://www.ebi.ac.uk/pdbsum/7cjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cjw ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cjw OCA], [https://pdbe.org/7cjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cjw RCSB], [https://www.ebi.ac.uk/pdbsum/7cjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cjw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[https://omim.org/entry/105400 105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref> <ref>PMID:19741096</ref> <ref>PMID:8528216</ref> <ref>PMID:8682505</ref> <ref>PMID:9541385</ref> <ref>PMID:12754496</ref> <ref>PMID:15056757</ref> <ref>PMID:18378676</ref> [:]<ref>PMID:8446170</ref> <ref>PMID:8351519</ref> <ref>PMID:8179602</ref> <ref>PMID:7980516</ref> <ref>PMID:8069312</ref> <ref>PMID:7951252</ref> <ref>PMID:7881433</ref> <ref>PMID:7836951</ref> <ref>PMID:7997024</ref> <ref>PMID:7870076</ref> <ref>PMID:7887412</ref> <ref>PMID:7795609</ref> <ref>PMID:7655468</ref> <ref>PMID:7655469</ref> <ref>PMID:7655471</ref> <ref>PMID:7700376</ref> <ref>PMID:7647793</ref> <ref>PMID:7501156</ref> <ref>PMID:7496169</ref> <ref>PMID:8938700</ref> <ref>PMID:8907321</ref> <ref>PMID:8990014</ref> <ref>PMID:9101297</ref> <ref>PMID:9455977</ref> <ref>PMID:10732812</ref> <ref>PMID:9131652</ref> <ref>PMID:10400992</ref> <ref>PMID:10430435</ref> <ref>PMID:11535232</ref> <ref>PMID:11369193</ref> <ref>PMID:12402272</ref> <ref>PMID:12145308</ref> <ref>PMID:14506936</ref> <ref>PMID:18552350</ref> <ref>PMID:18301754</ref> <ref>PMID:21247266</ref> <ref>PMID:21220647</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aggregate formation of superoxide dismutase 1 (SOD1) inside motor neurons is known as a major factor in onset of amyotrophic lateral sclerosis. The thermodynamic stability of the SOD1 beta-barrel has been shown to decrease in crowded environments such as inside a cell, but it remains unclear how the thermodynamics of crowding-induced protein destabilization relate to SOD1 aggregation. Here we have examined the effects of a protein crowder, lysozyme, on fibril aggregate formation of the SOD1 beta-barrel. We found that aggregate formation of SOD1 is decelerated even in mildly crowded solutions. Intriguingly, transient diffusive interactions with lysozyme do not significantly affect the static structure of the SOD1 beta-barrel but stabilize an alternative excited "invisible" state. The net effect of crowding is to favor species off the aggregation pathway, thereby explaining the decelerated aggregation in the crowded environment. Our observations suggest that the intracellular environment may have a similar negative (inhibitory) effect on fibril formation of other amyloidogenic proteins in living cells. Deciphering how crowded intracellular environments affect aggregation and fibril formation of such disease-associated proteins will probably become central in understanding the exact role of aggregation in the etiology of these enigmatic diseases.
		+
		+	Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 beta-Barrel.,Iwakawa N, Morimoto D, Walinda E, Leeb S, Shirakawa M, Danielsson J, Sugase K J Phys Chem B. 2021 Mar 18;125(10):2521-2532. doi: 10.1021/acs.jpcb.0c11162. Epub, 2021 Mar 3. PMID:33657322<ref>PMID:33657322</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7cjw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Danielsson J]]		[[Category: Danielsson J]]

OCA at 09:18, 26 May 2021

2021-05-26T09:18:51Z

←Older revision		Revision as of 09:18, 26 May 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7cjw is ~~ON HOLD until Paper Publication~~	+	==Solution structure of monomeric superoxide dismutase 1 with an additional mutation H46W in a crowded environment==
-		+	<StructureSection load='7cjw' size='340' side='right'caption='[[7cjw]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CJW FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cjw OCA], [https://pdbe.org/7cjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cjw RCSB], [https://www.ebi.ac.uk/pdbsum/7cjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cjw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Danielsson J]]
		+	[[Category: Iwakawa N]]
		+	[[Category: Morimoto D]]
		+	[[Category: Shirakawa M]]
		+	[[Category: Sugase K]]
		+	[[Category: Walinda E]]

OCA at 07:28, 9 September 2020

2020-09-09T07:28:08Z

←Older revision		Revision as of 07:28, 9 September 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7cjw is ON HOLD	+	The entry 7cjw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7cjw" [edit=sysop:move=sysop]

2020-07-22T08:36:50Z

Protected "7cjw" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:36, 22 July 2020

OCA: New page: '''Unreleased structure''' The entry 7cjw is ON HOLD Authors: Description: Category: Unreleased Structures

2020-07-22T08:36:48Z

New page: '''Unreleased structure''' The entry 7cjw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7cjw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7cjw - Revision history

OCA at 11:12, 14 June 2023

OCA at 09:18, 26 May 2021

OCA at 07:28, 9 September 2020

OCA: Protected "7cjw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7cjw is ON HOLD Authors: Description: Category: Unreleased Structures