7cmo - Revision history

OCA at 16:11, 29 November 2023

2023-11-29T16:11:00Z

←Older revision		Revision as of 16:11, 29 November 2023
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	<StructureSection load='7cmo' size='340' side='right'caption='[[7cmo]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='7cmo' size='340' side='right'caption='[[7cmo]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7cmo]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CMO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7CMO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7cmo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CMO FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PPA1, IOPPP, PP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>~~[~~http://en.wikipedia.org/wiki/Inorganic_diphosphatase Inorganic diphosphatase~~]~~, with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~3.~~6.1.1 3.6.1.1] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cmo OCA], [https://pdbe.org/7cmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cmo RCSB], [https://www.ebi.ac.uk/pdbsum/7cmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cmo ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cmo OCA], [~~http~~://pdbe.org/7cmo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7cmo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7cmo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7cmo ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IPYR_HUMAN IPYR_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7cmo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7cmo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Inorganic pyrophosphatase 3D structures\|Inorganic pyrophosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Inorganic diphosphatase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hu, F]]	+	[[Category: Hu F]]
-	[[Category: Huang, Z]]	+	[[Category: Huang Z]]
-	[[Category: Li, L]]	+	[[Category: Li L]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Monomer~~]]	+

OCA at 07:04, 30 December 2020

2020-12-30T07:04:59Z

←Older revision		Revision as of 07:04, 30 December 2020
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	==Crystal structure of human inorganic pyrophosphatase==		==Crystal structure of human inorganic pyrophosphatase==
-	<StructureSection load='7cmo' size='340' side='right'caption='[[7cmo]]' scene=''>	+	<StructureSection load='7cmo' size='340' side='right'caption='[[7cmo]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CMO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7CMO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7cmo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CMO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7CMO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cmo OCA], [http://pdbe.org/7cmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7cmo RCSB], [http://www.ebi.ac.uk/pdbsum/7cmo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7cmo ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPA1, IOPPP, PP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inorganic_diphosphatase Inorganic diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.1 3.6.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cmo OCA], [http://pdbe.org/7cmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7cmo RCSB], [http://www.ebi.ac.uk/pdbsum/7cmo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7cmo ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inorganic pyrophosphatase (PPase) plays an essential role in energy conservation and provides energy for many biosynthetic pathways. Here, we present two three-dimensional structures of PPase from Homo sapiens (Hu-PPase) at 2.38 A and 3.40 A in different crystallization conditions. One of the Hu-PPase structures complex of two magnesium metal ions was determined to be a monomer (Hu-PPase-mono) here, while the other one to be a dimer-dimer (Hu-PPase-dd). In each asymmetric unit of Hu-PPase-mono, there are four alpha-helices and ten beta-strands and folds as a barrel structure, and the active site contains two magnesium ions. Like PPases from many species, we found that Hu-PPase was able to undergo self-assembly. To our surprise, disruption of the self-assembly of Hu-PPase did not influence its enzymatic activity or the ability to promote cell growth. Our work uncovered that different structure forms of Hu-PPase and found that the pyrophosphatase activity of Hu-PPase is independent of its self-assembly.
		+
		+	Structural and biochemical characterization of inorganic pyrophosphatase from Homo sapiens.,Hu F, Huang Z, Zheng S, Wu Q, Chen Y, Lin H, Huang W, Li L Biochem Biophys Res Commun. 2020 Oct 6. pii: S0006-291X(20)31891-X. doi:, 10.1016/j.bbrc.2020.09.139. PMID:33036755<ref>PMID:33036755</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7cmo" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Inorganic diphosphatase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hu F]]	+	[[Category: Hu, F]]
-	[[Category: Huang Z]]	+	[[Category: Huang, Z]]
-	[[Category: Li L]]	+	[[Category: Li, L]]
		+	[[Category: Complex]]
		+	[[Category: Hydrolase]]
		+	[[Category: Monomer]]

OCA at 08:17, 21 October 2020

2020-10-21T08:17:40Z

←Older revision		Revision as of 08:17, 21 October 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7cmo ~~is ON HOLD until Jul 28 2022~~	+	==Crystal structure of human inorganic pyrophosphatase==
-		+	<StructureSection load='7cmo' size='340' side='right'caption='[[7cmo]]' scene=''>
-	~~Authors~~: Hu, F., ~~Huang~~, Z., Li, L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CMO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7CMO FirstGlance]. <br>
-	~~Description: Crystal structure of human inorganic pyrophosphatase~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cmo OCA], [http://pdbe.org/7cmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7cmo RCSB], [http://www.ebi.ac.uk/pdbsum/7cmo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7cmo ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Huang, Z~~]]	+	__TOC__
-	[[Category: ~~Hu, F~~]]	+	</StructureSection>
-	[[Category: Li, L]]	+	[[Category: Large Structures]]
		+	[[Category: Hu F]]
		+	[[Category: Huang Z]]
		+	[[Category: Li L]]

OCA at 09:21, 26 August 2020

2020-08-26T09:21:36Z

←Older revision		Revision as of 09:21, 26 August 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7cmo is ON HOLD	+	The entry 7cmo is ON HOLD until Jul 28 2022

	Authors: Hu, F., Huang, Z., Li, L.		Authors: Hu, F., Huang, Z., Li, L.

OCA: Protected "7cmo" [edit=sysop:move=sysop]

2020-08-05T04:10:50Z

Protected "7cmo" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:10, 5 August 2020

OCA: New page: '''Unreleased structure''' The entry 7cmo is ON HOLD Authors: Hu, F., Huang, Z., Li, L. Description: Crystal structure of human inorganic pyrophosphatase [[Category: Unreleased Structu...

2020-08-05T04:10:49Z

New page: '''Unreleased structure''' The entry 7cmo is ON HOLD Authors: Hu, F., Huang, Z., Li, L. Description: Crystal structure of human inorganic pyrophosphatase [[Category: Unreleased Structu...

New page

'''Unreleased structure'''

The entry 7cmo is ON HOLD

Authors: Hu, F., Huang, Z., Li, L.

Description: Crystal structure of human inorganic pyrophosphatase
[[Category: Unreleased Structures]]
[[Category: Huang, Z]]
[[Category: Hu, F]]
[[Category: Li, L]]