OCA at 16:12, 29 November 2023

2023-11-29T16:12:57Z

←Older revision		Revision as of 16:12, 29 November 2023
Line 1:		Line 1:

	==Structure of the CYP102A1 Haem Domain with N-Carboxybenzyl-L-Prolyl-L-Phenylalanine in complex with Cyclohexylamine==		==Structure of the CYP102A1 Haem Domain with N-Carboxybenzyl-L-Prolyl-L-Phenylalanine in complex with Cyclohexylamine==
-	<StructureSection load='7coo' size='340' side='right'caption='[[7coo]]' scene=''>	+	<StructureSection load='7coo' size='340' side='right'caption='[[7coo]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7COO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7COO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7coo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7COO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7COO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7coo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7coo OCA], [https://pdbe.org/7coo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7coo RCSB], [https://www.ebi.ac.uk/pdbsum/7coo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7coo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.49Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HAI:CYCLOHEXYLAMMONIUM+ION'>HAI</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZP6:(2S)-3-phenyl-2-[[(2S)-1-phenylmethoxycarbonylpyrrolidin-2-yl]carbonylamino]propanoic+acid'>ZP6</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7coo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7coo OCA], [https://pdbe.org/7coo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7coo RCSB], [https://www.ebi.ac.uk/pdbsum/7coo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7coo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CPXB_PRIM2 CPXB_PRIM2] Functions as a fatty acid monooxygenase (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Catalyzes hydroxylation of fatty acids at omega-1, omega-2 and omega-3 positions (PubMed:1727637, PubMed:21875028). Shows activity toward medium and long-chain fatty acids, with optimum chain lengths of 12, 14 and 16 carbons (lauric, myristic, and palmitic acids). Able to metabolize some of these primary metabolites to secondary and tertiary products (PubMed:1727637). Marginal activity towards short chain lengths of 8-10 carbons (PubMed:1727637, PubMed:18619466). Hydroxylates highly branched fatty acids, which play an essential role in membrane fluidity regulation (PubMed:16566047). Also displays a NADPH-dependent reductase activity in the C-terminal domain, which allows electron transfer from NADPH to the heme iron of the cytochrome P450 N-terminal domain (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Involved in inactivation of quorum sensing signals of other competing bacteria by oxidazing efficiently acyl homoserine lactones (AHLs), molecules involved in quorum sensing signaling pathways, and their lactonolysis products acyl homoserines (AHs) (PubMed:18020460).<ref>PMID:11695892</ref> <ref>PMID:14653735</ref> <ref>PMID:16403573</ref> <ref>PMID:16566047</ref> <ref>PMID:17077084</ref> <ref>PMID:1727637</ref> <ref>PMID:17868686</ref> <ref>PMID:18004886</ref> <ref>PMID:18020460</ref> <ref>PMID:18298086</ref> <ref>PMID:18619466</ref> <ref>PMID:18721129</ref> <ref>PMID:19492389</ref> <ref>PMID:20180779</ref> <ref>PMID:21110374</ref> <ref>PMID:21875028</ref> <ref>PMID:3106359</ref> <ref>PMID:7578081</ref>
		+
		+	==See Also==
		+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Priestia megaterium]]
	[[Category: Shoji O]]		[[Category: Shoji O]]
	[[Category: Stanfield JK]]		[[Category: Stanfield JK]]
	[[Category: Sugimoto H]]		[[Category: Sugimoto H]]

OCA at 09:25, 15 September 2021

2021-09-15T09:25:20Z

←Older revision		Revision as of 09:25, 15 September 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7coo is ~~ON HOLD until Sep 14 2022~~	+	==Structure of the CYP102A1 Haem Domain with N-Carboxybenzyl-L-Prolyl-L-Phenylalanine in complex with Cyclohexylamine==
-		+	<StructureSection load='7coo' size='340' side='right'caption='[[7coo]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7COO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7COO FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7coo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7coo OCA], [https://pdbe.org/7coo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7coo RCSB], [https://www.ebi.ac.uk/pdbsum/7coo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7coo ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Shoji O]]
		+	[[Category: Stanfield JK]]
		+	[[Category: Sugimoto H]]

OCA at 07:43, 21 July 2021

2021-07-21T07:43:29Z

←Older revision		Revision as of 07:43, 21 July 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7coo is ON HOLD until ~~Aug 04~~ 2022	+	The entry 7coo is ON HOLD until Sep 14 2022

	Authors:		Authors:

OCA at 06:47, 16 September 2020

2020-09-16T06:47:53Z

←Older revision		Revision as of 06:47, 16 September 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7coo is ON HOLD	+	The entry 7coo is ON HOLD until Aug 04 2022

	Authors:		Authors:

OCA: Protected "7coo" [edit=sysop:move=sysop]

2020-08-12T08:24:05Z

Protected "7coo" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:24, 12 August 2020

OCA: New page: '''Unreleased structure''' The entry 7coo is ON HOLD Authors: Description: Category: Unreleased Structures

2020-08-12T08:24:04Z

New page: '''Unreleased structure''' The entry 7coo is ON HOLD Authors: Description: Category: Unreleased Structures

New page