7csr - Revision history

OCA at 16:15, 29 November 2023

2023-11-29T16:15:42Z

←Older revision		Revision as of 16:15, 29 November 2023
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	<StructureSection load='7csr' size='340' side='right'caption='[[7csr]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='7csr' size='340' side='right'caption='[[7csr]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7csr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CSR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7csr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CSR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7csr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csr OCA], [https://pdbe.org/7csr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7csr RCSB], [https://www.ebi.ac.uk/pdbsum/7csr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7csr ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7csr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csr OCA], [https://pdbe.org/7csr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7csr RCSB], [https://www.ebi.ac.uk/pdbsum/7csr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7csr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ARHGG_MOUSE ARHGG_MOUSE]] Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 (By similarity).	+	[https://www.uniprot.org/uniprot/ARHGG_MOUSE ARHGG_MOUSE] Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7csr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7csr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rho guanine nucleotide exchange factor 3D structures\|Rho guanine nucleotide exchange factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lin, L]]	+	[[Category: Mus musculus]]
-	[[Category: Wang, C]]	+	[[Category: Lin L]]
-	[[Category: Zhang, M]]	+	[[Category: Wang C]]
-	[[Category: Zhu, J]]	+	[[Category: Zhang M]]
-	~~[[Category: Autoinhibition]]~~	+	[[Category: Zhu J]]
-	~~[[Category: Ephexin4]]~~	+
-	~~[[Category: Gef]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 15:02, 3 March 2021

2021-03-03T15:02:01Z

←Older revision		Revision as of 15:02, 3 March 2021
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	==Structure of Ephexin4 R676L==		==Structure of Ephexin4 R676L==
-	<StructureSection load='7csr' size='340' side='right'caption='[[7csr]]' scene=''>	+	<StructureSection load='7csr' size='340' side='right'caption='[[7csr]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CSR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7csr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CSR FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7csr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csr OCA], [https://pdbe.org/7csr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7csr RCSB], [https://www.ebi.ac.uk/pdbsum/7csr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7csr ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7csr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csr OCA], [https://pdbe.org/7csr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7csr RCSB], [https://www.ebi.ac.uk/pdbsum/7csr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7csr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/ARHGG_MOUSE ARHGG_MOUSE]] Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ephexin family guanine nucleotide exchange factors (GEFs) transfer signals from Eph tyrosine kinase receptors to Rho GTPases, which play critical roles in diverse cellular processes, as well as cancers and brain disorders. Here, we elucidate the molecular basis underlying inhibition and activation of Ephexin family RhoGEFs. The crystal structures of partially and fully autoinhibited Ephexin4 reveal that the complete autoinhibition requires both N- and C-terminal inhibitory modes, which can operate independently to impede Ras homolog family member G (RhoG) access. This double inhibition mechanism is commonly employed by other Ephexins and SGEF, another RhoGEF for RhoG. Structural, enzymatic, and cell biological analyses show that phosphorylation of a conserved tyrosine residue in its N-terminal inhibitory domain and association of PDZ proteins with its C-terminal PDZ-binding motif may respectively relieve the two autoinhibitory modes in Ephexin4. Our study provides a mechanistic framework for understanding the fine-tuning regulation of Ephexin4 GEF activity and offers possible clues for its pathological dysfunction.
		+
		+	Double inhibition and activation mechanisms of Ephexin family RhoGEFs.,Zhang M, Lin L, Wang C, Zhu J Proc Natl Acad Sci U S A. 2021 Feb 23;118(8). pii: 2024465118. doi:, 10.1073/pnas.2024465118. PMID:33597305<ref>PMID:33597305</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7csr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lin L]]	+	[[Category: Lin, L]]
-	[[Category: Wang C]]	+	[[Category: Wang, C]]
-	[[Category: Zhang M]]	+	[[Category: Zhang, M]]
-	[[Category: Zhu J]]	+	[[Category: Zhu, J]]
		+	[[Category: Autoinhibition]]
		+	[[Category: Ephexin4]]
		+	[[Category: Gef]]
		+	[[Category: Signaling protein]]

OCA at 06:40, 24 February 2021

2021-02-24T06:40:14Z

←Older revision		Revision as of 06:40, 24 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7csr is ~~ON HOLD~~	+	==Structure of Ephexin4 R676L==
-		+	<StructureSection load='7csr' size='340' side='right'caption='[[7csr]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CSR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7csr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csr OCA], [https://pdbe.org/7csr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7csr RCSB], [https://www.ebi.ac.uk/pdbsum/7csr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7csr ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lin L]]
		+	[[Category: Wang C]]
		+	[[Category: Zhang M]]
		+	[[Category: Zhu J]]

OCA: Protected "7csr" [edit=sysop:move=sysop]

2020-08-26T09:26:02Z

Protected "7csr" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:26, 26 August 2020

OCA: New page: '''Unreleased structure''' The entry 7csr is ON HOLD Authors: Description: Category: Unreleased Structures

2020-08-26T09:26:01Z

New page: '''Unreleased structure''' The entry 7csr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7csr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]