7cz2 - Revision history

OCA at 16:20, 29 November 2023

2023-11-29T16:20:49Z

←Older revision		Revision as of 16:20, 29 November 2023
Line 3:		Line 3:
	<StructureSection load='7cz2' size='340' side='right'caption='[[7cz2]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='7cz2' size='340' side='right'caption='[[7cz2]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7cz2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CZ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7cz2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CZ2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cz2 OCA], [https://pdbe.org/7cz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cz2 RCSB], [https://www.ebi.ac.uk/pdbsum/7cz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cz2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cz2 OCA], [https://pdbe.org/7cz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cz2 RCSB], [https://www.ebi.ac.uk/pdbsum/7cz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cz2 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0QTT2_MYCS2 A0QTT2_MYCS2]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Rao, Z H~~]]	+	[[Category: Mycolicibacterium smegmatis MC2 155]]
-	[[Category: ~~Zhang, Q~~]]	+	[[Category: Rao ZH]]
-	[[Category: ~~Adp binding]]~~	+	[[Category: Zhang Q]]
-	~~[[Category: Antibiotic binding]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 08:34, 23 February 2022

2022-02-23T08:34:08Z

←Older revision		Revision as of 08:34, 23 February 2022
Line 1:		Line 1:

	==The complex structure of MSMEG_1954-ADP from Mycobacterium smegmatis==		==The complex structure of MSMEG_1954-ADP from Mycobacterium smegmatis==
-	<StructureSection load='7cz2' size='340' side='right'caption='[[7cz2]]' scene=''>	+	<StructureSection load='7cz2' size='340' side='right'caption='[[7cz2]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CZ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7cz2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CZ2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cz2 OCA], [https://pdbe.org/7cz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cz2 RCSB], [https://www.ebi.ac.uk/pdbsum/7cz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cz2 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cz2 OCA], [https://pdbe.org/7cz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cz2 RCSB], [https://www.ebi.ac.uk/pdbsum/7cz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cz2 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rv3197 (MABP-1), a non-canonical ABC protein in Mycobacterium tuberculosis, has ATPase activity and confers inducible resistance to the macrolide family of antibiotics. Here we have shown that MSMEG_1954, the homolog of Rv3197 in M. smegmatis, has a similar function of conferring macrolide resistance. Crystal structures of apo-MSMEG_1954 (form1 and form 2) and MSMEG_1954 in complex with ADP have been determined. These three structures show that MSMEG_1954 has at least two different conformations we identify as closed state (MSMEG_1954-form 1) and open state (MSMEG_1954-form 2 and MSMEG_1954-ADP). Structural superimposition shows that the MSMEG_1954-form 2 and MSMEG_1954-ADP complex have similar conformation to that observed for MABP-1 and MABP-1-erythromicin complex structure. However, the antibiotic binding pocket in MSMEG_1954-form 1 is completely blocked by the N-terminal accessory domain. When bound by ADP, the N-terminal accessory domain undergoes conformational change, which results in the open of the antibiotic binding pocket. Because of the degradation of N terminal accessory domain in MSMSG_1954-form 2, it is likely to represent a transitional state between MSMEG_1954-form 1 and MSMEG_1954-ADP complex structure.
		+
		+	Conformational Changes in a Macrolide Antibiotic Binding Protein From Mycobacterium smegmatis Upon ADP Binding.,Zhang Q, Liu X, Liu H, Zhang B, Yang H, Mi K, Guddat LW, Rao Z Front Microbiol. 2021 Dec 9;12:780954. doi: 10.3389/fmicb.2021.780954., eCollection 2021. PMID:34956144<ref>PMID:34956144</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7cz2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Rao ZH]]	+	[[Category: Rao, Z H]]
-	[[Category: Zhang Q]]	+	[[Category: Zhang, Q]]
		+	[[Category: Adp binding]]
		+	[[Category: Antibiotic binding]]
		+	[[Category: Transport protein]]

OCA at 09:54, 8 December 2021

2021-12-08T09:54:09Z

←Older revision		Revision as of 09:54, 8 December 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 7cz2 ~~is ON HOLD until Dec 04 2022~~	+	==The complex structure of MSMEG_1954-ADP from Mycobacterium smegmatis==
-		+	<StructureSection load='7cz2' size='340' side='right'caption='[[7cz2]]' scene=''>
-	~~Authors~~: ~~Zhang~~, Q., ~~Rao~~, Z.H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CZ2 FirstGlance]. <br>
-	~~Description~~: ~~The complex structure of MSMEG_1954~~-~~ADP from Mycobacterium smegmatis~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cz2 OCA], [https://pdbe.org/7cz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cz2 RCSB], [https://www.ebi.ac.uk/pdbsum/7cz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cz2 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Rao~~, Z.H~~]]	+	__TOC__
-	[[Category: Zhang, Q]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Rao ZH]]
		+	[[Category: Zhang Q]]

OCA at 04:58, 1 December 2021

2021-12-01T04:58:23Z

←Older revision		Revision as of 04:58, 1 December 2021
Line 5:		Line 5:
	Authors: Zhang, Q., Rao, Z.H.		Authors: Zhang, Q., Rao, Z.H.

-	Description: The complex structure of ~~Msmeg1954~~-ADP from Mycobacterium smegmatis	+	Description: The complex structure of MSMEG_1954-ADP from Mycobacterium smegmatis
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Rao, Z.H]]		[[Category: Rao, Z.H]]
	[[Category: Zhang, Q]]		[[Category: Zhang, Q]]

OCA at 04:53, 18 August 2021

2021-08-18T04:53:39Z

←Older revision		Revision as of 04:53, 18 August 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7cz2 is ON HOLD	+	The entry 7cz2 is ON HOLD until Dec 04 2022

	Authors: Zhang, Q., Rao, Z.H.		Authors: Zhang, Q., Rao, Z.H.

OCA: Protected "7cz2" [edit=sysop:move=sysop]

2020-09-16T06:52:48Z

Protected "7cz2" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:52, 16 September 2020

OCA: New page: '''Unreleased structure''' The entry 7cz2 is ON HOLD Authors: Zhang, Q., Rao, Z.H. Description: The complex structure of Msmeg1954-ADP from Mycobacterium smegmatis [[Category: Unreleas...

2020-09-16T06:52:47Z

New page: '''Unreleased structure''' The entry 7cz2 is ON HOLD Authors: Zhang, Q., Rao, Z.H. Description: The complex structure of Msmeg1954-ADP from Mycobacterium smegmatis [[Category: Unreleas...

New page

'''Unreleased structure'''

The entry 7cz2 is ON HOLD

Authors: Zhang, Q., Rao, Z.H.

Description: The complex structure of Msmeg1954-ADP from Mycobacterium smegmatis
[[Category: Unreleased Structures]]
[[Category: Rao, Z.H]]
[[Category: Zhang, Q]]